{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:58:39Z","timestamp":1792403919247,"version":"4.4.0"},"reference-count":21,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2015,6,26]]},"abstract":"\n Purpose :<\/jats:title>\n To report visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after iodine-125 brachytherapy for choroidal and ciliary body melanoma (CCM).<\/jats:p>\n <\/jats:sec>\n \n Design :<\/jats:title>\n Prospective interventional case series.<\/jats:p>\n <\/jats:sec>\n \n Participants :<\/jats:title>\n Thirty-seven patients (37 eyes) with CCM.<\/jats:p>\n <\/jats:sec>\n \n Methods :<\/jats:title>\n Patients had best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, Pelli-Robson contrast sensitivity and Hardy-Rand-Rittler color vision measurement; comprehensive ophthalmology examination; optical coherence tomography; and ultrasonography at baseline prior to, 1 year after, 2 years after and 3 years after I-125 brachytherapy.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures :<\/jats:title>\n Visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after brachytherapy.<\/jats:p>\n <\/jats:sec>\n \n Results :<\/jats:title>\n Nineteen (19) men and 18 women with mean age of 58 years (SD 13, range 30-78) prior to, 1 year after, 2 years\nafter and 3 years after brachytherapy had mean best-corrected visual acuity of 77 letters (20\/32), 65 letters (20\/50), 56\nletters (20\/80) and 47 letters (20\/125); contrast sensitivity of 30, 26, 22 and 19 letters; color vision of 26, 20, 17 and 14\ntest figures, respectively. Decrease in visual acuity, contrast sensitivity and color vision was statistically significant from\nbaseline at 1 year, 2 years, and 3 years after brachytherapy. Decreased acuity at 3 years was associated with mid-choroid\nand macula melanoma location, \u2265 4.1 mm melanoma height, radiation maculopathy and radiation optic neuropathy.<\/jats:p>\n <\/jats:sec>\n \n Conclusion :<\/jats:title>\n 1, 2 and 3 years after brachytherapy, eyes with CCM had significantly decreased visual acuity, contrast sensitivity and color vision.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1874364101509010131","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T03:25:57Z","timestamp":1437017157000},"page":"131-135","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Visual Acuity, Contrast Sensitivity and Color Vision Three Years After Iodine-125 Brachytherapy for Choroidal and Ciliary Body Melanoma"],"prefix":"10.2174","volume":"9","author":[{"given":"Irena","family":"Tsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Beardsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara A","family":"McCannel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa W","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve P","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip E","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nzhde","family":"Agazaryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley R","family":"Straatsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.ophtha.2011.01.040","volume":"118","author":"Singh AD","year":"2011","unstructured":"Singh AD, Turell MD, Topham AK. \n Uveal Melanoma Trends in incidence, treatment, and survival \n Ophthalmology \n 2011; \n 118\n : 1881-5.","journal-title":"Ophthalmology"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archopht.119.7.969","volume":"119","author":"Diener-West M","year":"2001","unstructured":"Diener-West M, Earle JD, Fine SL , et al. \n The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma.III. 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