{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:14:41Z","timestamp":1757704481559},"reference-count":28,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2015,7,31]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose :<\/jats:title>\n                    <jats:p> To compare the levels of conjunctival transforming growth factor beta (TGF-\u03b2) between glaucoma and control patients and to determine conjunctival TGF-\u03b2 levels before and 3 months after augmented primary trabeculectomy.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Methods :<\/jats:title>\n                    <jats:p> Patients with primary open angle glaucoma (POAG) or primary angle closure glaucoma (PACG) admitted for mitomycin (MMC) augmented primary trabeculectomy due to failure in achieving target pressure after maximum medical therapy were selected. Age-matched non-glaucoma patients were controls. Impression cytology of the conjunctiva was obtained twice from glaucoma patients (1 week before augmented primary trabeculectomy and 3 months after surgery) and once from controls. Conjunctival cells were tagged with an anti-TGF-\u03b2 antibody and analyzed by flow cytometry.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Results :<\/jats:title>\n                    <jats:p> Eighteen patients (11 POAG and 7 PACG patients) and 18 age-matched control patients were included. Conjunctival TGF-\u03b2 levels were significantly different between glaucoma (35.21% \u00b1 14.12%) and control patients (14.96% \u00b1 6.34%) (p = 0.001). There was a significant reduction in conjunctival TGF-\u03b2 levels after augmented trabeculectomy (23.0% \u00b1 13.8%) (p &lt; 0.001). A significantly greater reduction in conjunctival TGF-\u03b2 levels (61.6% \u00b1 17.9%) was associated with complete success of trabeculectomy at 3 months (83.3%) after surgical intervention (p = 0.029).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                    <jats:title>Conclusion :<\/jats:title>\n                    <jats:p> The reduction of TGF-\u03b2 on the conjunctival post primary augmented trabeculectomy may suggest TGF-\u03b2 as potential predicting marker of short term trabeculectomy success. However, the result may be affected by site of impression, topical pressure lowering drugs and small sample size.<\/jats:p>\n                <\/jats:sec>","DOI":"10.2174\/1874364101509010136","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T04:42:38Z","timestamp":1439872958000},"page":"136-144","update-policy":"http:\/\/dx.doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Conjunctival TGF-B Level in Primary Augmented Trabeculectomy"],"prefix":"10.2174","volume":"9","author":[{"given":"Guan Fook","family":"Ng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishak Siti","family":"Raihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaakub","family":"Azhany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che Hussin Che","family":"Maraina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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