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We also considered the dependent variable NFI (Neural Fiber Index) of GDx scanning laser polarimetry. Progression has been evaluated through a statistic General Linear Model on four follow up steps (mean follow up 79 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Factors reaching statistical significance, determining a worsening of the MD variable, are: age (<jats:italic>P<\/jats:italic>&lt;0.0001), intraocular pressure (IOP) at follow up (<jats:italic>P<\/jats:italic>&lt; 0.0001), female gender (<jats:italic>P<\/jats:italic>&lt;0.0001), hypertension (<jats:italic>P<\/jats:italic>&lt; 0.0001) and familiarity (<jats:italic>P<\/jats:italic>= 0.0006).<\/jats:p><jats:p>Factors reaching statistical significance, determining a worsening of the NFI variable, are only IOP at follow up (<jats:italic>P<\/jats:italic>= 0.0159) and depression (<jats:italic>P<\/jats:italic>= 0.0104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Results of this study confirm and enforce data coming from most recent studies: IOP remains the main risk factor for glaucoma assess and progression; age and familiarity are great risk factors as underlined in the last decades; female sex can be an important risk factors as emerged only in the last years; arterial hypertension should always be evaluated in timing of our clinic follow up.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874364101610010129","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T04:32:09Z","timestamp":1462163529000},"page":"129-139","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Risk Factors for Primary Open Angle Glaucoma (POAG) Progression: A Study Ruled in Torino"],"prefix":"10.2174","volume":"10","author":[{"given":"A.G.","family":"Actis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Versino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Brogliatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Rolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","unstructured":"Gandolfi S. 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