{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:29:01Z","timestamp":1789774141725,"version":"4.0.1"},"reference-count":22,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2018,7,23]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>LASIK Xtra is a recently described technique which combines LASIK and accelerated corneal cross-linking(CXL) in the same setting. Its long-term outcome in Asians with high myopia is not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>To compare the efficacy, predictability and safety of LASIK Xtra with LASIK in patients with high myopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>This is a retrospective study comparing 50 consecutive eyes undergoing LASIK Xtra for the correction of high myopia and\/or myopic astigmatism (-6.63 to -15.50 D manifest spherical equivalent) with a matched control group of 50 eyes undergoing LASIK alone for correction of high myopia (-6.00 to -12.25 D manifest spherical equivalent). Mean follow-up was 5.7 months (range, 1.5-13.3 months) for LASIK Xtra and 3.6 months (range, 1.7-4.2 months) for LASIK only. Outcome measures included Uncorrected Distance Visual Acuity (UDVA), Corrected Distance Visual Acuity (CDVA), refraction and intraoperative and postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>At post-operative 3 months, all eyes achieved UDVA of 20\/40 or better, and 80.0% of LASIK Xtra eyes achieved UDVA of 20\/20 or better, compared to 66.0% of LASIK only eyes (<jats:italic>p<\/jats:italic>= 0.115). Efficacy indices were 0.99\u00b10.17 for LASIK Xtra and 0.94\u00b10.17 for LASIK only (<jats:italic>p<\/jats:italic>= 0.164). The proportion of eyes within \u00b10.50 D of attempted correction was 84% in the LASIK only group and 72% in the LASIK Xtra group at post-operative 3 months (<jats:italic>p<\/jats:italic>= 0.148). Safety indices were 1.11\u00b10.19 and 1.11\u00b10.18 in the LASIK Xtra and LASIK only groups, respectively (<jats:italic>p<\/jats:italic>= 0.735).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>LASIK Xtra achieved comparable safety, predictability and efficacy as LASIK in patients with high myopia. Good refractive stability was attained at 6-12 months. Further long term studies are required to determine whether simultaneous CXL is able to reduce postoperative LASIK keratectasia in high-risk individuals.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874364101812010143","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T11:05:14Z","timestamp":1532084714000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Simultaneous Accelerated Corneal Crosslinking and Laser In situ Keratomileusis for the Treatment of High Myopia in Asian Eyes"],"prefix":"10.2174","volume":"12","author":[{"given":"Jin Rong","family":"Low","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Chwee Wah","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Kai Peng","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Rosman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","first-page":"CD005135","author":"Shortt A.J.","year":"2013","unstructured":"Shortt AJ, Allan BDS, Evans JR. 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