{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:44:38Z","timestamp":1787024678716,"version":"build-2736575974"},"reference-count":41,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openophthalmologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOOPHTJ"],"published-print":{"date-parts":[[2018,8,31]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The causes, clinical presentations and treatment outcomes of optic neuritis are distinct among different populations. Early diagnosis based on clinical presentations plays an important role in treating optic neuritis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The study aimed to determine clinical characteristics, treatment outcomes and predictive factors of treatment outcomes in optic neuritis patients with and without demyelinating disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective descriptive study of optic neuritis patients carried out between January 2009 and December 2016 was done. Univariate analysis and multivariate logistic regression analysis were used to evaluate the predictive factors of treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 150 patients with optic neuritis, 58 patients were diagnosed with Neuromyelitis Optica Spectrum Disease (NMOSD), 23 patients were diagnosed with Multiple Sclerosis (MS) and 69 patients were idiopathic. The age at presentation in the NMOSD group was significantly younger than the MS group and the idiopathic group. The female:male ratio was significantly lower in the idiopathic group than in the NMOSD group. The initial Best Corrected Visual Activity (BCVA) of 20\/20-20\/60 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001) and the idiopathic group (\n                      <jats:italic>p<\/jats:italic>\n                      =0.030) was associated with good visual outcomes. Initial BCVA of &lt; 20\/200 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009) and the NMOSD group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) was associated with poor visual outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NMOSD is a more common cause of optic neuritis than MS in Thai population. Female patients with poor initial VA, poor response to steroids treatment, and presenting recurrent attacks are highly suspicious for NMOSD. Optic neuritis without associated demyelinating disease has a better visual outcome and lower recurrence rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1874364101812010247","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T07:49:07Z","timestamp":1536565747000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical Characteristics, Treatment Outcomes and Predictive Factors in Optic Neuritis"],"prefix":"10.2174","volume":"12","author":[{"given":"Linda","family":"Hansapinyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayanee","family":"Vivattanaseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1056\/NEJM199202273260901","volume":"326","author":"Beck R.W.","year":"1992","unstructured":"Beck RW, Cleary PA, Anderson MM Jr, et al. \n                    A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. \n                    N Engl J Med  \n                    1992; \n                    326\n                    (9)\n                    : 581-8.","journal-title":"N. Engl. J. Med."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1001\/archopht.1991.01080120057025","volume":"109","year":"1991","unstructured":"The clinical profile of optic neuritis. Experience of the optic neuritis treatment trial. \n                    Arch Ophthalmol  \n                    1991; \n                    109\n                    (12)\n                    : 1673-8.","journal-title":"Arch. Ophthalmol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","volume":"13","author":"Toosy A.T.","year":"2014","unstructured":"Toosy AT, Mason DF, Miller DH. \n                    Optic neuritis. \n                    Lancet Neurol  \n                    2014; \n                    13\n                    (1)\n                    : 83-99.","journal-title":"Lancet Neurol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.autrev.2013.03.012","volume":"12","author":"St\u00fcbgen J.P.","year":"2013","unstructured":"St\u00fcbgen JP. \n                    A literature review on optic neuritis following vaccination against virus infections. \n                    Autoimmun Rev  \n                    2013; \n                    12\n                    (10)\n                    : 990-7.","journal-title":"Autoimmun. Rev."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.ophtha.2007.08.004","volume":"115","author":"Brodsky M.","year":"2008","unstructured":"Brodsky M, Orengo-Nania S, Hutton GJ, et al. \n                    Optic Neuritis Study Group. \n                    Visual function 15 years after optic neuritis: A final follow-up report from the optic neuritis treatment trial. \n                    Ophthalmology  \n                    2008; \n                    115\n                    (6)\n                    : 1079-1082.e5.","journal-title":"Ophthalmology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","volume":"6","author":"Wingerchuk D.M.","year":"2007","unstructured":"Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. \n                    The spectrum of neuromyelitis optica. \n                    Lancet Neurol  \n                    2007; \n                    6\n                    (9)\n                    : 805-15.","journal-title":"Lancet Neurol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1093\/brain\/aws109","volume":"135","author":"Kitley J.","year":"2012","unstructured":"Kitley J, Leite MI, Nakashima I, et al. \n                    Prognostic factors and disease course in aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder from the United Kingdom and Japan. \n                    Brain  \n                    2012; \n                    135\n                    (Pt 6)\n                    : 1834-49.","journal-title":"Brain"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.2174\/0929866524666170110150436","volume":"24","author":"Lin N.","year":"2017","unstructured":"Lin N, Liu Q, Wang X, Ma J, Li Y. \n                    Role of AQP4 antibody serostatus and its prediction of visual outcome in neuromyelitis optica: A systematic review and meta-analysis. \n                    Protein Pept Lett  \n                    2017; \n                    24\n                    (3)\n                    : 245-52.","journal-title":"Protein Pept. Lett."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1007\/s00417-010-1344-7","volume":"248","author":"Nakamura M.","year":"2010","unstructured":"Nakamura M, Nakazawa T, Doi H, et al. \n                    Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica. \n                    Graefes Arch Clin Exp Ophthalmol  \n                    2010; \n                    248\n                    (12)\n                    : 1777-85.","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.msard.2018.03.003","volume":"21","author":"Soelberg K.","year":"2018","unstructured":"Soelberg K, Nilsson AC, Nielsen C, et al. \n                    Autoimmune and immunogenetic profile of patients with optic neuritis in a population-based cohort. \n                    Mult Scler Relat Disord  \n                    2018; \n                    21\n                    : 97-102.","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3109\/01658107.2013.804232","volume":"37","author":"de Seze J.","year":"2013","unstructured":"de Seze J. \n                    Inflammatory optic neuritis: From multiple sclerosis to neuromyelitis optica. \n                    Neuroophthalmology  \n                    2013; \n                    37\n                    (4)\n                    : 141-5.","journal-title":"Neuroophthalmology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jns.2010.07.011","volume":"298","author":"Jarius S.","year":"2010","unstructured":"Jarius S, Frederikson J, Waters P, et al. \n                    Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. \n                    J Neurol Sci  \n                    2010; \n                    298\n                    (1-2)\n                    : 158-62.","journal-title":"J. Neurol. Sci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/WNO.0b013e3181f8a693","volume":"31","author":"Lai C.","year":"2011","unstructured":"Lai C, Tian G, Takahashi T, Liu W, Yang L, Zhang X. \n                    Neuromyelitis optica antibodies in patients with severe optic neuritis in China. \n                    J Neuroophthalmol  \n                    2011; \n                    31\n                    (1)\n                    : 16-9.","journal-title":"J. Neuroophthalmol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/j.1468-1331.2008.02376.x","volume":"16","author":"Chan K.H.","year":"2009","unstructured":"Chan KH, Ramsden DB, Yu YL, et al. \n                    Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese. \n                    Eur J Neurol  \n                    2009; \n                    16\n                    (3)\n                    : 310-6.","journal-title":"Eur. J. Neurol."},{"key":"ref15","first-page":"93","volume":"99","author":"Wakakura M.","year":"1995","unstructured":"Wakakura M, Ishikawa S, Oono S, et al. \n                    Incidence of acute idiopathic optic neuritis and its therapy in Japan. \n                    Nippon Ganka Gakkai Zasshi  \n                    1995; \n                    99\n                    (1)\n                    : 93-7.","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0022-510X(98)00141-5","volume":"159","author":"Jin Y.P.","year":"1998","unstructured":"Jin YP, de Pedro-Cuesta J, S\u00f6derstr\u00f6m M, Stawiarz L, Link H. \n                    Incidence of optic neuritis in Stockholm, Sweden 1990-1995: I. Age, sex, birth and ethnic-group related patterns. \n                    J Neurol Sci  \n                    1998; \n                    159\n                    (1)\n                    : 107-14.","journal-title":"J. Neurol. Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1093\/brain\/123.4.665","volume":"123","author":"MacDonald B.K.","year":"2000","unstructured":"MacDonald BK, Cockerell OC, Sander JW, Shorvon SD. \n                    The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. \n                    Brain  \n                    2000; \n                    123\n                    (Pt 4)\n                    : 665-76.","journal-title":"Brain"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","volume":"85","author":"Wingerchuk D.M.","year":"2015","unstructured":"Wingerchuk DM, Banwell B, Bennett JL, et al. \n                    International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. \n                    Neurology  \n                    2015; \n                    85\n                    (2)\n                    : 177-89.","journal-title":"Neurology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ana.22366","volume":"69","author":"Polman C.H.","year":"2011","unstructured":"Polman CH, Reingold SC, Banwell B, et al. \n                    Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. \n                    Ann Neurol  \n                    2011; \n                    69\n                    (2)\n                    : 292-302.","journal-title":"Ann. Neurol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.autrev.2018.01.001","volume":"17","author":"Bruscolini A.","year":"2018","unstructured":"Bruscolini A, Sacchetti M, La Cava M, et al. \n                    Diagnosis and management of neuromyelitis optica spectrum disorders - An update. \n                    Autoimmun Rev  \n                    2018; \n                    17\n                    (3)\n                    : 195-200.","journal-title":"Autoimmun. Rev."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00415-013-6957-4","volume":"261","author":"Petzold A.","year":"2014","unstructured":"Petzold A, Plant GT. \n                    Chronic relapsing inflammatory optic neuropathy: A systematic review of 122 cases reported. \n                    J Neurol  \n                    2014; \n                    261\n                    (1)\n                    : 17-26.","journal-title":"J. Neurol."},{"key":"ref22","first-page":"215","volume":"33","author":"Kim K.M.","year":"2018","unstructured":"Kim KM, Kim US. \n                    Aquaporin 4 antibody in the korean patient with new-onset optic neuritis. \n                    Semin Ophthalmol  \n                    2018; \n                    33\n                    (2)\n                    : 215-8.","journal-title":"Semin. Ophthalmol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1007\/s00415-016-8155-7","volume":"263","author":"Zhou H.","year":"2016","unstructured":"Zhou H, Zhao S, Yin D, et al. \n                    Optic neuritis: A 5-year follow-up study of Chinese patients based on aquaporin-4 antibody status and ages. \n                    J Neurol  \n                    2016; \n                    263\n                    (7)\n                    : 1382-9.","journal-title":"J. Neurol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1007\/s00415-015-7844-y","volume":"262","author":"Li H.","year":"2015","unstructured":"Li H, Wang Y, Xu Q, et al. \n                    Features of anti-aquaporin 4 antibody-seropositive Chinese patients with neuromyelitis optica spectrum optic neuritis. \n                    J Neurol  \n                    2015; \n                    262\n                    (10)\n                    : 2293-304.","journal-title":"J. Neurol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1001\/jamaophthalmol.2017.6757","volume":"136","author":"Chen J.J.","year":"2018","unstructured":"Chen JJ, Tobin WO, Majed M, et al. \n                    Prevalence of myelin oligodendrocyte glycoprotein and aquaporin-4-IgG in patients in the optic neuritis treatment trial. \n                    JAMA Ophthalmol  \n                    2018; \n                    136\n                    (4)\n                    : 419-22.","journal-title":"JAMA Ophthalmol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000485120","volume":"10","author":"Hollen C.","year":"2018","unstructured":"Hollen C, Suhaib O, Farrow A, Sidorov E. \n                    Elderly-onset neuromyelitis optica spectrum disorder with pre-existing prednisone allergy. \n                    Case Rep Neurol  \n                    2018; \n                    10\n                    (1)\n                    : 25-8.","journal-title":"Case Rep. Neurol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s00415-015-7766-8","volume":"262","author":"Krumbholz M.","year":"2015","unstructured":"Krumbholz M, Hofstadt-van Oy U, Angstwurm K, et al. \n                    Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75. \n                    J Neurol  \n                    2015; \n                    262\n                    (5)\n                    : 1379-84.","journal-title":"J. Neurol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1136\/bjophthalmol-2017-310157","volume":"101","author":"Zhou H.","year":"2017","unstructured":"Zhou H, Xu Q, Zhao S, et al. \n                    Distinct clinical characteristics of atypical optic neuritis with seronegative aquaporin-4 antibody among Chinese patients. \n                    Br J Ophthalmol  \n                    2017; \n                    101\n                    (12)\n                    : 1720-4.","journal-title":"Br. J. Ophthalmol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.msard.2017.01.004","volume":"12","author":"Eskandarieh S.","year":"2017","unstructured":"Eskandarieh S, Nedjat S, Abdollahpour I, Moghadasi AN, Azimi AR, Sahraian MA. \n                    Comparing epidemiology and baseline characteristic of multiple sclerosis and neuromyelitis optica: A case-control study. \n                    Mult Scler Relat Disord  \n                    2017; \n                    12\n                    : 39-43.","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1136\/jnnp.2008.146894","volume":"81","author":"Petzold A.","year":"2010","unstructured":"Petzold A, Pittock S, Lennon V, Maggiore C, Weinshenker BG, Plant GT. \n                    Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis. \n                    J Neurol Neurosurg Psychiatry  \n                    2010; \n                    81\n                    (1)\n                    : 109-11.","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1136\/jnnp-2011-300403","volume":"82","author":"Nagaishi A.","year":"2011","unstructured":"Nagaishi A, Takagi M, Umemura A, et al. \n                    Clinical features of neuromyelitis optica in a large Japanese cohort: Comparison between phenotypes. \n                    J Neurol Neurosurg Psychiatry  \n                    2011; \n                    82\n                    (12)\n                    : 1360-4.","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/0972-2327.128559","volume":"17","author":"Barhate K.S.","year":"2014","unstructured":"Barhate KS, Ganeshan M, Singhal BS. \n                    A clinical and radiological profile of neuromyelitis optica and spectrum disorders in an Indian cohort. \n                    Ann Indian Acad Neurol  \n                    2014; \n                    17\n                    (1)\n                    : 77-81.","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/08820530390895172","volume":"18","author":"Boomer J.A.","year":"2003","unstructured":"Boomer JA, Siatkowski RM. \n                    Optic neuritis in adults and children. \n                    Semin Ophthalmol  \n                    2003; \n                    18\n                    (4)\n                    : 174-80.","journal-title":"Semin. Ophthalmol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1136\/bjo.2005.085399","volume":"90","author":"de la Cruz J.","year":"2006","unstructured":"de la Cruz J, Kupersmith MJ. \n                    Clinical profile of simultaneous bilateral optic neuritis in adults. \n                    Br J Ophthalmol  \n                    2006; \n                    90\n                    (5)\n                    : 551-4.","journal-title":"Br. J. Ophthalmol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/eye.2001.157","volume":"15","author":"Pokroy R.","year":"2001","unstructured":"Pokroy R, Modi G, Saffer D. \n                    Optic neuritis in an urban black African community. \n                    Eye (Lond)  \n                    2001; \n                    15\n                    (Pt 4)\n                    : 469-73.","journal-title":"Eye (Lond.)"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1046\/j.1442-9071.2001.00442.x","volume":"29","author":"Wang J.C.","year":"2001","unstructured":"Wang JC, Tow S, Aung T, Lim SA, Cullen JF. \n                    The presentation, aetiology, management and outcome of optic neuritis in an Asian population. \n                    Clin Experiment Ophthalmol  \n                    2001; \n                    29\n                    (5)\n                    : 312-5.","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/WNO.0b013e31823a9ebc","volume":"32","author":"Fernandes D.B.","year":"2012","unstructured":"Fernandes DB, Ramos RdeI, Falcochio C, Ap\u00f3stolos-Pereira S, Callegaro D, Monteiro ML. \n                    Comparison of visual acuity and automated perimetry findings in patients with neuromyelitis optica or multiple sclerosis after single or multiple attacks of optic neuritis. \n                    J Neuroophthalmol  \n                    2012; \n                    32\n                    (2)\n                    : 102-6.","journal-title":"J. Neuroophthalmol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0021-5155(98)00072-0","volume":"43","author":"Wakakura M.","year":"1999","unstructured":"Wakakura M, Minei-Higa R, Oono S, et al. \n                    Baseline features of idiopathic optic neuritis as determined by a multicenter treatment trial in Japan. \n                    Jpn J Ophthalmol  \n                    1999; \n                    43\n                    (2)\n                    : 127-32.","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s10384-005-0281-1","volume":"50","author":"Lin Y.C.","year":"2006","unstructured":"Lin YC, Yen MY, Hsu WM, Lee HC, Wang AG. \n                    Low conversion rate to multiple sclerosis in idiopathic optic neuritis patients in Taiwan. \n                    Jpn J Ophthalmol  \n                    2006; \n                    50\n                    (2)\n                    : 170-5.","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/eye.2014.144","volume":"29","author":"Miller N.R.","year":"2015","unstructured":"Miller NR, Arnold AC. \n                    Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy. \n                    Eye (Lond)  \n                    2015; \n                    29\n                    (1)\n                    : 65-79.","journal-title":"Eye (Lond.)"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1177\/1756285617709723","volume":"10","author":"Kim S.M.","year":"2017","unstructured":"Kim SM, Kim SJ, Lee HJ, Kuroda H, Palace J, Fujihara K. \n                    Differential diagnosis of neuromyelitis optica spectrum disorders. \n                    Ther Adv Neurol Disorder  \n                    2017; \n                    10\n                    (7)\n                    : 265-89.","journal-title":"Ther. Adv. Neurol. Disorder."}],"container-title":["The Open Ophthalmology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V12\/TOOPHTJ-12-247\/TOOPHTJ-12-247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V12\/TOOPHTJ-12-247\/TOOPHTJ-12-247.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openophthalmologyjournal.com\/contents\/volumes\/V12\/TOOPHTJ-12-247\/TOOPHTJ-12-247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T02:34:38Z","timestamp":1555295678000},"score":1,"resource":{"primary":{"URL":"https:\/\/openophthalmologyjournal.com\/VOLUME\/12\/PAGE\/247\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,8,31]]}},"alternative-id":["TOOPHTJ-12-247"],"URL":"https:\/\/doi.org\/10.2174\/1874364101812010247","relation":{},"ISSN":["1874-3641"],"issn-type":[{"value":"1874-3641","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,31]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-6-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-7-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-7-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}