{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T02:13:07Z","timestamp":1778983987321,"version":"3.51.4"},"reference-count":31,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T00:00:00Z","timestamp":1311724800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["openmedicalinformaticsjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOMINFOJ"],"published-print":{"date-parts":[[2011,7,27]]},"abstract":"<jats:p>The current imaging methods have a limited ability to visualize microstructures of biological soft tissues. Small lesions cannot be detected at the early stage of the disease. Phase contrast imaging (PCI) is a novel non-invasive imaging technique that can provide high contrast images of soft tissues by the use of X-ray phase shift. It is a new choice in terms of non-invasively revealing soft tissue details. In this study, the lung and hepatic fibrosis models of mice and rats were used to investigate the ability of PCI in microstructures observation of soft tissues. Our results demonstrated that different liver fibrosis stages could be distinguished non-invasively by PCI. The three-dimensional morphology of a segment of blood vessel was constructed. Noteworthy, the blood clot inside the vessel was visualized in three dimensions which provided a precise description of vessel stenosis. Furthermore, the whole lung airways including the alveoli were obtained. We had specifically highlighted its use in the visualization and assessment of the alveoli. To our knowledge, this was the first time for non-invasive alveoli imaging using PCI. This finding may offer a new perspective on the diagnosis of respiratory disease. All the results confirmed that PCI will be a valuable tool in biological soft tissues imaging.<\/jats:p>","DOI":"10.2174\/1874431101105010019","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T05:34:51Z","timestamp":1332999291000},"page":"19-25","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Micro Soft Tissues Visualization Based on X-Ray Phase-Contrast Imaging"],"prefix":"10.2174","volume":"5","author":[{"given":"Lu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"e6670","DOI":"10.1371\/journal.pone.0006670","volume":"4","author":"Jacob RE","year":"2009","unstructured":"Jacob RE, Carson JP, Gideon KM, Amidan BG, Smith CL, Lee KM. \n                Comparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice \n                PLoS ONE  \n                2009; \n                4\n                (8)\n                : e6670.","journal-title":"PLoS ONE"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.juro.2007.03.128","volume":"178","author":"Dall\u2019Oglio MF","year":"2007","unstructured":"Dall\u2019Oglio MF, Ribeiro-Filho LA, Antunes AA, et al. \n                Microvascular tumor invasion, tumor size and Fuhrman grade: a pathological triad for prognostic evaluation of renal cell carcinoma \n                J Urol  \n                2007; \n                178\n                (2\n                )\n                : 425-8.","journal-title":"J Urol"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2009.04.006","volume":"164","author":"Reitz C","year":"2009","unstructured":"Reitz C, Mayeux R. \n                Endophenotypes in normal brain morphology and alzheimer's disease: a review \n                Neuroscience  \n                2009; \n                164\n                (1\n                )\n                : 174-90.","journal-title":"Neuroscience"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gut.2005.084475","volume":"55","author":"Standish RA","year":"2006","unstructured":"Standish RA, Cholongitas E, Dhillon A, Burroughs AK,  Dhillon AP. \n                An appraisal of the histopathological assessment of liver fibrosis \n                Gut  \n                2006; \n                55\n                (4\n                )\n                : 569-78.","journal-title":"Gut"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1148\/radiol.2261011974","volume":"226","author":"Biederer J","year":"2003","unstructured":"Biederer J, Both M, Graessner J, et al. \n                 Lung morphology: fast MR imaging assessment with a volumetric interpolated breath-hold technique: initial experience with patients \n                Radiology  \n                2003; \n                226\n                (1\n                )\n                : 242-49.","journal-title":"Radiology"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0140-6736(99)08003-4","volume":"355","author":"Hoffman PC","year":"2000","unstructured":"Hoffman PC, Mauer AM, Vokes EE. \n                Lung cancer \n                Lancet  \n                2000; \n                355\n                (9202\n                )\n                : 479-85.","journal-title":"Lancet"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/384335a0","volume":"384","author":"Wilkins SW","year":"1996","unstructured":"Wilkins SW, Gureyev TE, Gao D, Pogany A, Stevenson AW. \n                Phase-contrast imaging using polychromatic hard X-rays \n                Nature  \n                1996; \n                384\n                (6607\n                )\n                : 335-8.","journal-title":"Nature"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1118\/1.1593836","volume":"30","author":"Wu X","year":"2003","unstructured":"Wu X, Liu H. \n                Clinical implementation of phase contrast x-ray imaging: theoretical foundation and design considerations \n                Med Phys  \n                2003; \n                30\n                (8\n                )\n                : 2169-79.","journal-title":"Med Phys"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nm0496-473","volume":"2","author":"Momose A","year":"1996","unstructured":"Momose A, Takeda T, Itai Y, Hirano K. \n                Phase-contrast x-ray computed tomography for observing biological soft tissues \n                Nat Med  \n                1996; \n                2\n                (4\n                )\n                : 473-5.","journal-title":"Nat Med"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/373595a0","volume":"373","author":"Davis T J","year":"1995","unstructured":"Davis T J, Gao D, Gureyev T E, Stevenson AW, Wilkins SW. \n                Phase-contrast imaging of weakly absorbing materials using hard X-rays \n                Nature  \n                1995; \n                373\n                (6515\n                )\n                : 595-8.","journal-title":"Nature"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nphys265","volume":"2","author":"Pfeiffer F","year":"2006","unstructured":"Pfeiffer F, Weitkamp T, Bunk O, David C. \n                Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sourced \n                Nat Phys  \n                2006; \n                2\n                (4\n                )\n                : 258-61.","journal-title":"Nat Phys"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1259\/bjr\/32889803","volume":"76","author":"Lewis RA","year":"2003","unstructured":"Lewis RA, Hall CJ, Hufton AP, et al. \n                X-ray refraction effects: application to the imaging of biological tissues \n                Br J Radiol  \n                2003; \n                76\n                (905)\n                : 301-8.","journal-title":"Br J Radiol"},{"key":"refR13","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1088\/0031-9155\/49\/16\/005","volume":"49","author":"Lewis RA","year":"2004","unstructured":"Lewis RA. \n                Medical phase contrast x-ray imaging: current status and future prospects \n                Phys Med Biol  \n                2004; \n                49\n                (16\n                )\n                : 3573-83.","journal-title":"Phys Med Biol"},{"key":"refR14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1148\/radiology.214.1.r00ja08298","volume":"214","author":"Takeda T","year":"2000","unstructured":"Takeda T, Momose A, Hirano K, Haraoka S, Watanabe T, Itai Y. \n                Human carcinoma: early experience with phase-contrast X-ray CT with synchrotron radiation\u2014comparative specimen study with optical microscopy \n                Radiology  \n                2000; \n                214\n                (1\n                )\n                : 298-301.","journal-title":"Radiology"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.nima.2005.03.070","volume":"548","author":"Ohtsuka S","year":"2005","unstructured":"Ohtsuka S, Hyodo K, Jin W, et al. \n                Overview of clinical intravenous coronary angiography both in Japan and at ESRF \n                Nucl Instrum Meth A  \n                2005; \n                548\n                (1-2\n                )\n                : 78-83.","journal-title":"Nucl Instrum Meth A"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1259\/bjr\/13024611","volume":"78","author":"Kitchen MJ","year":"2005","unstructured":"Kitchen MJ, Lewis RA, Yagi N, et al. \n                Phase contrast X-ray imaging of mice and rabbit lungs: a comparative study \n                Brit J Radiol  \n                2005; \n                78\n                (935\n                )\n                : 1018-27.","journal-title":"Brit J Radiol"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1107\/S090904950200554X","volume":"9","author":"Suzuki Y","year":"2002","unstructured":"Suzuki Y, Yagi N, Uesugi K. \n                X-ray refraction-enhanced imaging and a method for phase retrieval for a simple object \n                J Synchrotron Radiat  \n                2002; \n                9\n                : 160-5.","journal-title":"J Synchrotron Radiat"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1088\/0031-9155\/42\/11\/001","volume":"42","author":"Chapman D","year":"1997","unstructured":"Chapman D, Thomlinson W, Johnston RE, et al. \n                Diffraction enhanced X-ray imaging \n                Phys Med Biol  \n                1997; \n                42\n                (11\n                )\n                : 2015-5.","journal-title":"Phys Med Biol"},{"key":"refR19","unstructured":"Kak AC, Slaney M. \n                Principles of computerized tomographic imaging. \n                New York: IEEE Press 1988."},{"key":"refR20","unstructured":"Luo S,  Zhou G. \n                Medical Image Processing and Analysis.  2st. \n                Beijing: Science Press 2010.\n                \n                \n                \n                \n             [in Chinese]"},{"key":"refR21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/gast.2003.50013","volume":"124","author":"Dienstag JL","year":"2003","unstructured":"Dienstag JL, Goldin RD, Heathcote EJ, et al. \n                Histological outcome during long-term lamivudine therapy \n                Gastroenterology  \n                2003; \n                124\n                (1\n                )\n                : 105-7.","journal-title":"Gastroenterology"},{"key":"refR22","doi-asserted-by":"crossref","first-page":"124101","DOI":"10.1063\/1.3104860","volume":"94","author":"Li H","year":"2009","unstructured":"Li H, Zhang L, Wang XY, et al. \n                Investigation of hepatic fibrosis in rats with X-ray diffraction enhanced imaging \n                Appl Phys Lett  \n                2009; \n                94\n                (12\n                )\n                : 124101-3.","journal-title":"Appl Phys Lett"},{"key":"refR23","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1681\/ASN.2006090976","volume":"18","author":"Zhu XY","year":"2007","unstructured":"Zhu XY, Daghini E, Chade AR, et al. \n                Simvastatin prevents coronary microvascular remodeling in renovascular hypertensive pigs \n                J Am Soc Nephrol  \n                2007; \n                18\n                (4\n                )\n                : 1209-7.","journal-title":"J Am Soc Nephrol"},{"key":"refR24","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mvr.2008.04.003","volume":"76","author":"Gomes MB","year":"2008","unstructured":"Gomes MB, Matheus AS, Tibiri\u00e7\u00e1 E. \n                Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: Which method to choose? \n                Microvasc Res  \n                2008; \n                76\n                (2\n                )\n                : 132-3.","journal-title":"Microvasc Res"},{"key":"refR25","author":"Zhang L","year":"2010","unstructured":"Zhang L, Hu C, Zhao T, Luo S. \n                Noninvasive visualization of microvessels using diffraction enhanced imaging \n                Eur J Radiol \n                2010.\n                \n             [Epub ahead of print]","journal-title":"Eur J Radiol"},{"key":"refR26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.legalmed.2003.08.007","volume":"6","author":"Hausmann R","year":"2004","unstructured":"Hausmann R, Bock H, Biermann T, Betz P. \n                Influence of lung fixation technique on the state of alveolar expansion\u2014a histomorphometrical study \n                Legal Med  \n                2004; \n                6\n                (1\n                )\n                : 61-5.","journal-title":"Legal Med"},{"key":"refR27","doi-asserted-by":"crossref","first-page":"e17400","DOI":"10.1371\/journal.pone.0017400","volume":"6","author":"Zhang L","year":"2011","unstructured":"Zhang L, Li D, Luo S. \n                Non-invasive microstructure and morphology investigation of the mouse lung: qualitative description and quantitative measurement \n                PLoS ONE  \n                2011; \n                6\n                (2\n                )\n                : e17400.","journal-title":"PLoS ONE"},{"key":"refR28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jhep.2008.02.008","volume":"48","author":"Castera L","year":"2008","unstructured":"Castera L, Forns X, Alberti A. \n                Non-invasive evaluation of liver fibrosis using transient elastography \n                J Hepatol  \n                2008; \n                48\n                (5\n                )\n                : 835-47.","journal-title":"J Hepatol"},{"key":"refR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phrs.2007.03.003","volume":"56","author":"Cutroneo P","year":"2007","unstructured":"Cutroneo P, Polimeni G, Curcuruto R, Calapai G, Caputi AP. \n                Adverse reactions to contrast media: An analysis from spontaneous reporting data \n                Pharmacol Res  \n                2007; \n                56\n                (1\n                )\n                : 35-41.","journal-title":"Pharmacol Res"},{"key":"refR30","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/CIRCULATIONAHA.106.660779","volume":"115","author":"Bahrmann P","year":"2007","unstructured":"Bahrmann P, Werner GS, Heusch G, et al. \n                Detection of coronary microembolization by doppler ultrasound in patients with stable angina pectoris undergoing elective percutaneous coronary interventions \n                Circulation  \n                2007; \n                115\n                (5\n                )\n                : 600-8.","journal-title":"Circulation"},{"key":"refR31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1469-7580.2008.00950.x","volume":"213","author":"Parsons DW","year":"2008","unstructured":"Parsons DW, Morgan K, Donnelley M, et al. \n                High resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI) \n                J Anat  \n                2008; \n                213\n                (2\n                )\n                : 217-7.","journal-title":"J Anat"}],"container-title":["The Open Medical Informatics Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openmedicalinformaticsjournal.com\/contents\/volumes\/V5\/TOMINFOJ-5-19\/TOMINFOJ-5-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmedicalinformaticsjournal.com\/contents\/volumes\/V5\/TOMINFOJ-5-19\/TOMINFOJ-5-19.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmedicalinformaticsjournal.com\/contents\/volumes\/V5\/TOMINFOJ-5-19\/TOMINFOJ-5-19.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T06:30:14Z","timestamp":1564036214000},"score":1,"resource":{"primary":{"URL":"https:\/\/openmedicalinformaticsjournal.com\/VOLUME\/5\/PAGE\/19\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,27]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7,27]]}},"alternative-id":["TOMINFOJ-5-19"],"URL":"https:\/\/doi.org\/10.2174\/1874431101105010019","relation":{},"ISSN":["1874-4311"],"issn-type":[{"value":"1874-4311","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,27]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2011-5-6","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-5-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-5-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-7-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}