{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:47:51Z","timestamp":1788468471745,"version":"build-2803163510"},"reference-count":35,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openneuroimagingjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TONIJ"],"published-print":{"date-parts":[[2018,1,22]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Any mismatch between the production and absorption of CSF results in hydrocephalus. In most cases, the selected choice of treatment is the ventriculoperitoneal shunt insertion. Although, the surgery could have complications such as infection, shunt malfunction, subdural hematoma, seizure and Shunt immigration; so, the early and proper detection of these complications could result in better prognosis. The aim of this study was to evaluate and compare the efficacy of CT scan, CSF analysis and X-ray radiography in detection of shunt complications and problems in shunt placement and further follow-up in hospitalized children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The medical records of children in Rasul Akram hospital in Tehran were reviewed retrospectively in the last 10 years, from 2006 to 2016. All data were recorded in the prepared form including the age, sex, shunt complication, CT scan and CSF characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The total number of 95 patients were interfered in this study including 56 males (58.9%) and 39 females (41.1%). The mean age at the onset of complications were 2.8\u00b12.2 years-old. The shunt obstruction (60%) and infection (25.3%) were the most common complications. The CT scan was able to detect 36.5% of shunt complications. The CT scan had the sensitivity and specificity of 50 and 87%, respectively in detection of shunt obstruction. The all cases of brain hematoma and hemorrhage were revealed by CT scan. On the other hand, the CT scan had 20% of sensitivity and 60% of specificity in the detection of shunt infection. The CSF evaluation in shunt infection revealed 92% hypoglycemia, 87.5% pleocytosis, and 62.5% positive CSF culture. CSF had the sensitivity, specificity, positive predictive value and negative predictive value of 92, 82, 63 and 97%, respectively. The patient's symptoms and signs were helpful in obtaining higher test accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The CT scan was not a good sensitive and specific study in the detection of shunt obstruction and infection, but it was very accurate in detection of hemorrhage and hematoma. On the other hand, CSF evaluation was a reliable test in shunt infection disclosure.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1874440001812010001","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T09:32:17Z","timestamp":1516613537000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Neuroimaging Studies in Children with Ventriculoperitoneal Shunt Complications: A 10 Years Descriptive Study in Tehran"],"prefix":"10.2174","volume":"12","author":[{"given":"Mohammad Vafaee","family":"Shahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samileh","family":"Noorbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Zarrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banafsheh","family":"Nourozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Tahernia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","unstructured":"Anderson CE, Garton HJ, Kestle JR. Treatment of hydrocephalus with shunts. In: Albright L, Ed. Principles and practice of pediatric neurosurgery 2007; 109-30."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.pediatrneurol.2005.05.021","volume":"34","author":"Browd S.R.","year":"2006","unstructured":"Browd SR, Gottfried ON, Ragel BT, Kestle JR. Failure of cerebrospinal fluid shunts: part II: Overdrainage, loculation, and abdominal complications. Pediatr Neurol 2006; 34 (3) : 171-76. http:\/\/www.ajronline.org\/doi\/full\/10.2214\/AJR.12.10270","journal-title":"Pediatr. Neurol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1097\/00006123-199808000-00068","volume":"43","author":"Drake J.M.","year":"1998","unstructured":"Drake JM, Kestle JR, Milner R, et al. Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. Neurosurgery 1998; 43 (2) : 294-303.","journal-title":"Neurosurgery"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1542\/peds.89.3.470","volume":"89","author":"Piatt J.H.","year":"1992","unstructured":"Piatt JH Jr. Physical examination of patients with cerebrospinal fluid shunts: Is there useful information in pumping the shunt? Pediatrics 1992; 89 (3) : 470-73.","journal-title":"Pediatrics"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00381-003-0752-y","volume":"19","author":"O\u2019Brien D.F.","year":"2003","unstructured":"O\u2019Brien DF, Taylor M, Park TS, Ojemann JG. A critical analysis of \u2018normal\u2019 radionucleotide shuntograms in patients subsequently requiring surgery. Childs Nerv Syst 2003; 19 (5-6) : 337-41.","journal-title":"Childs Nerv. Syst."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/BF00335171","volume":"10","author":"Di Rocco C.","year":"1994","unstructured":"Di Rocco C, Marchese E, Velardi F. A survey of the first complication of newly implanted CSF shunt devices for the treatment of nontumoral hydrocephalus. Cooperative survey of the 1991-1992 Education Committee of the ISPN. Childs Nerv Syst 1994; 10 (5) : 321-7.","journal-title":"Childs Nerv. Syst."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.pediatrneurol.2005.05.020","volume":"34","author":"Browd S.R.","year":"2006","unstructured":"Browd SR, Ragel BT, Gottfried ON, Kestle JR. Failure of cerebrospinal fluid shunts: part I: Obstruction and mechanical failure. Pediatr Neurol 2006; 34 (2) : 83-92.","journal-title":"Pediatr. Neurol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1053\/j.sult.2006.01.009","volume":"27","author":"Coley B.D.","year":"2006","unstructured":"Coley BD, Kosnik EJ. Abdominal complications of ventriculoperitoneal shunts in children. Semin Ultrasound CT MR 2006; 27 (2) : 152-60.","journal-title":"Semin. Ultrasound CT MR"},{"key":"ref9","first-page":"635","volume":"18","author":"Goser C.","year":"1998","unstructured":"Goser C. Diagnosing imaging of ventricoloperitoneal shunt in children. Radlo Graphics 1998; 18 (1) : 635-5.","journal-title":"Radlo Graphics"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1159\/000083738","volume":"40","author":"Olson S.","year":"2004","unstructured":"Olson S. The problematic slit ventricle syndrome. A review of the literature and proposed algorithm for treatment. Pediatr Neurosurg 2004; 40 (6) : 264-69.","journal-title":"Pediatr. Neurosurg."},{"key":"ref11","unstructured":"Teo C. Slit ventricle syndrome. Textbook of neurological surgery 2003; 875-80."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1159\/000083737","volume":"40","author":"Rekate H.L.","year":"2004","unstructured":"Rekate HL. The slit ventricle syndrome: advances based on technology and understanding. Pediatr Neurosurg 2004; 40 (6) : 259-63.","journal-title":"Pediatr. Neurosurg."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000056054","volume":"36","author":"Le H.","year":"2002","unstructured":"Le H, Yamini B, Frim DM. Lumboperitoneal shunting as a treatment for slit ventricle syndrome. Pediatr Neurosurg 2002; 36 (4) : 178-82.","journal-title":"Pediatr. Neurosurg."},{"key":"ref14","first-page":"350","volume":"106","author":"Kariyattil R.","year":"2007","unstructured":"Kariyattil R, Steinbok P, Singhal A, Cochrane DD. Ascites and abdominal pseudocysts following ventriculoperitoneal shunt surgery: Variations of the same theme. J Neurosurg 2007; 106 (5) (Suppl.) : 350-5.","journal-title":"J. Neurosurg."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00381-006-0183-7","volume":"23","author":"de Oliveira R.S.","year":"2007","unstructured":"de Oliveira RS, Barbosa A, Vicente YA, Machado HR. An alternative approach for management of abdominal cerebrospinal fluid pseudocysts in children. Childs Nerv Syst 2007; 23 (1) : 85-90.","journal-title":"Childs Nerv. Syst."},{"key":"ref16","first-page":"213","volume":"107","author":"Arnell K.","year":"2007","unstructured":"Arnell K, Enblad P, Wester T, Sj\u00f6lin J. Treatment of cerebrospinal fluid shunt infections in children using systemic and intraventricular antibiotic therapy in combination with externalization of the ventricular catheter: efficacy in 34 consecutively treated infections. J Neurosurg 2007; 107 (3) (Suppl.) : 213-9.","journal-title":"J. Neurosurg."},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Shayanfar N, Mohammadpour M. Invasive bacteria isolates from children with cerebral shunt and pattern of antimicrobial drug susceptibility in an Iranian referral pediatrics center Journal of Infectious - SciELO Brasi 2011.","DOI":"10.1016\/S1413-8670(11)70215-X"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Jouibari MF, Baradaran N, Amiri RS, Nejat F. Huge hydrocephalus: Definition, management, and complications Child\u2019s Nervous 2011; 27 (1) (Suppl.) : 95-100.","DOI":"10.1007\/s00381-010-1177-z"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Radmanesh F, Nejat F. M El Khashab - Infection in myelomeningocele after VP shunt placement Child\u2019s Nervous System 2011; 27 : 341-2.","DOI":"10.1007\/s00381-010-1376-7"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Behjati S, Emami-Naeini P, Nejat F. Incidence of hydrocephalus and the need to ventriculoperitoneal shunting in premature infants with intraventricular hemorrhage: Risk factors and outcome \u2026 - Child\u2019s Nervous System 2011.","DOI":"10.1007\/s00381-010-1387-4"},{"key":"ref21","unstructured":"Aftab K, Shoaib M. 2013; Nosocomial bacterial meningitis-prevention rather than cure! JPMA. The Journal of the Pakistan Medical http:\/\/jpma.org.pk 2013; 63 (7) : 945."},{"key":"ref22","first-page":"1691","volume":"128","author":"Karppinen A.","year":"2012","unstructured":"Karppinen A. Complications of hydrocephalus shunting. Duodecim 2012; 128 (16) : 1691-8. [Complications of hydrocephalus shunting]. [Review].","journal-title":"Duodecim"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/PEC.0b013e3180328c77","volume":"23","author":"Pitetti R.","year":"2007","unstructured":"Pitetti R. Emergency department evaluation of ventricular shunt malfunction: Is the shunt series really necessary? Pediatr Emerg Care 2007; 23 (3) : 137-41.","journal-title":"Pediatr. Emerg. Care"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1007\/BF00261592","volume":"12","author":"Caldarelli M.","year":"1996","unstructured":"Caldarelli M, Di Rocco C, La Marca F. Shunt complications in the first postoperative year in children with meningomyelocele. Childs Nerv Syst 1996; 12 (12) : 748-54.","journal-title":"Childs Nerv. Syst."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3171\/2010.11.PEDS10244","volume":"7","author":"Fulkerson D.H.","year":"2011","unstructured":"Fulkerson DH, Vachhrajani S, Bohnstedt BN, et al. Analysis of the risk of shunt failure or infection related to cerebrospinal fluid cell count, protein level, and glucose levels in low-birth-weight premature infants with posthemorrhagic hydrocephalus. J Neurosurg Pediatr 2011; 7 (2) : 147-51.","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1055\/s-2004-817896","volume":"14","author":"Arnell K.","year":"2004","unstructured":"Arnell K, Olsen L. Distal catheter obstruction from non-infectious cause in ventriculo-peritoneal shunted children. Eur J Pediatr Surg 2004; 14 (4) : 245-9.","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3171\/jns.2003.98.5.1027","volume":"98","author":"Nishiyama K.","year":"2003","unstructured":"Nishiyama K, Mori H, Tanaka R. Changes in cerebrospinal fluid hydrodynamics following endoscopic third ventriculostomy for shunt-dependent noncommunicating hydrocephalus. J Neurosurg 2003; 98 (5) : 1027-31.","journal-title":"J. Neurosurg."},{"key":"ref28","doi-asserted-by":"publisher","author":"Rocque BG","unstructured":"Rocque BG, Lapsiwala S, Iskandar BJ. Ventricular shunt tap as a predictor of proximal shunt malfunction in children: A prospective study. J Neurosurg Pediatr 2015; 1(6): 439-43","DOI":"10.1097\/PEC.0000000000000462"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/PEC.0b013e31816a8d43","volume":"24","author":"Piatt J.H.","year":"2008","unstructured":"Piatt JH Jr, Garton HJ, Iskandar BJ. Clinical diagnosis of ventriculoperitoneal shunt failure among children with hydrocephalus. Pediatr Emerg Care 2008; 24 (4) : 201-10.","journal-title":"Pediatr. Emerg. Care"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3171\/jns.2001.94.2.0202","volume":"94","author":"Garton H.J.","year":"2001","unstructured":"Garton HJ, Kestle JR, Drake JM. Predicting shunt failure on the basis of clinical symptoms and signs in children. J Neurosurg 2001; 94 (2) : 202-10.","journal-title":"J. Neurosurg."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/PEC.0000000000000462","volume":"31","author":"Boyle T.P.","year":"2015","unstructured":"Boyle TP, Nigrovic LE. Radiographic evaluation of pediatric cerebrospinal fluid shunt malfunction in the emergency setting. Pediatr Emerg Care 2015; 31 (6) : 435-40.","journal-title":"Pediatr. Emerg. Care"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10140-011-0955-6","volume":"18","author":"Lehnert B.E.","year":"2011","unstructured":"Lehnert BE, Rahbar H, Relyea-Chew A, Lewis DH, Richardson ML, Fink JR. Detection of ventricular shunt malfunction in the ED: Relative utility of radiography, CT, and nuclear imaging. Emerg Radiol 2011; 18 (4) : 299-305.","journal-title":"Emerg. Radiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s10140-006-0557-x","volume":"13","author":"Griffey R.T.","year":"2007","unstructured":"Griffey RT, Ledbetter S, Khorasani R. Yield and utility of radiographic \u201cshunt series\u201d in the evaluation of ventriculo-peritoneal shunt malfunction in adult emergency patients. Emerg Radiol 2007; 13 (6) : 307-11.","journal-title":"Emerg. Radiol."},{"key":"ref34","author":"Dorsett Maia","year":"2015","unstructured":"Dorsett Maia. maiadorsett Faculty Reviewed by Peter Panagos and Richard Griffey. An Imperfect Science: Diagnosis of CSF Shunt Malfunction. Wash U EM Residency June 2015.","journal-title":"Wash U EM Residency June"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Zhang Hongri, Peng Jinghua, Xiaowei Hao, XiaofanGuo GangL. A Simple and Reliable Method for the Diagnosis of Ventriculoperitoneal Shunt Malfunction. 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