{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:25:23Z","timestamp":1780669523033,"version":"3.54.1"},"reference-count":100,"publisher":"Elsevier BV","issue":"2","funder":[{"DOI":"10.13039\/501100001691","name":"Grant-in-Aid for Scientific Research","doi-asserted-by":"publisher","award":["20780209"],"award-info":[{"award-number":["20780209"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Grant-in-Aid for Scientific Research","doi-asserted-by":"publisher","award":["23780300"],"award-info":[{"award-number":["23780300"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Grant-in-Aid for Scientific Research","doi-asserted-by":"publisher","award":["25292174"],"award-info":[{"award-number":["25292174"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMP"],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>IL-19 is a type of anti-inflammatory cytokine. Since the receptor for IL-19 is common to\nIL-20 and IL-24, it is important to clarify the role of each of the three cytokines. If three different\ncytokines bind to the same receptor, these three may have been produced to complement the other\ntwo. However, perhaps it is unlikely. Recently, the existence of a novel receptor for IL-19 was\nsuggested. The distinction between the roles of the three cytokines still makes sense. On the other\nhand, because T cells do not produce IL-19, their role in acquired immunity is limited or indirect. It\nhas been reported that IL-19 causes inflammation in some diseases but does not have an anti-inflammatory\neffect. In this review, we introduce the current role of IL-19 in each disease. In addition,\nwe will describe the molecular mechanism of IL-19 and its development for the prevention of\ndiseases. IL-19 was previously considered an anti-inflammatory cytokine, but we would like to propose\nit as an immunoregulatory cytokine.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874467213666200424151528","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T15:26:56Z","timestamp":1587742016000},"page":"191-199","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Interleukin-19 as an Immunoregulatory Cytokine"],"prefix":"10.1016","volume":"14","author":[{"given":"Yasuyuki","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Sciences, Izumisano, Osaka598-8531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2565-2067","authenticated-orcid":true,"given":"Nobuyuki","family":"Kuramoto","sequence":"additional","affiliation":[{"name":"The Institute of Prophylactic Pharmacology, Kita-Shinagawa, Shinagawa, 140-0001, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-3171","authenticated-orcid":true,"given":"Masanori","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"The Institute of Prophylactic Pharmacology, Kita-Shinagawa, Shinagawa, 140-0001, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3515-171X","authenticated-orcid":true,"given":"Yasu-Taka","family":"Azuma","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Sciences, Izumisano, Osaka598-8531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nri3766","volume":"14","author":"Rutz S.","year":"2014","unstructured":"Rutz S.; Wang X.; Ouyang W.; The IL-20 subfamily of cytokines--from host defence to tissue homeostasis. Nat Rev Immunol 2014,14(12),783-795","journal-title":"Nat Rev Immunol"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1254\/fpj.154.66","volume":"154","author":"Fujimoto Y.","year":"2019","unstructured":"Fujimoto Y.; Azuma Y.T.; [Recent progress in the pathophysiological role of interleukin-19]. Nippon Yakurigaku Zasshi 2019,154(2),66-71","journal-title":"Nippon Yakurigaku Zasshi"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/sj.gene.6363714","volume":"1","author":"Gallagher G.","year":"2000","unstructured":"Gallagher G.; Dickensheets H.; Eskdale J.; Izotova L.S.; Mirochnitchenko O.V.; Peat J.D.; Vazquez N.; Pestka S.; Donnelly R.P.; Kotenko S.V.; Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Immun 2000,1(7),442-450","journal-title":"Genes Immun"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.jaci.2008.02.026","volume":"121","author":"Commins S.","year":"2008","unstructured":"Commins S.; Steinke J.W.; Borish L.; The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. J Allergy Clin Immunol 2008,121(5),1108-1111","journal-title":"J Allergy Clin Immunol"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0092-8674(01)00187-8","volume":"104","author":"Blumberg H.","year":"2001","unstructured":"Blumberg H.; Conklin D.; Xu W.F.; Grossmann A.; Brender T.; Carollo S.; Eagan M.; Foster D.; Haldeman B.A.; Hammond A.; Haugen H.; Jelinek L.; Kelly J.D.; Madden K.; Maurer M.F.; Parrish-Novak J.; Prunkard D.; Sexson S.; Sprecher C.; Waggie K.; West J.; Whitmore T.E.; Yao L.; Kuechle M.K.; Dale B.A.; Chandrasekher Y.A.; Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 2001,104(1),9-19","journal-title":"Cell"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"47517","DOI":"10.1074\/jbc.M205114200","volume":"277","author":"Parrish-Novak J.","year":"2002","unstructured":"Parrish-Novak J.; Xu W.; Brender T.; Yao L.; Jones C.; West J.; Brandt C.; Jelinek L.; Madden K.; McKernan P.A.; Foster D.C.; Jaspers S.; Chandrasekher Y.A.; Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem 2002,277(49),47517-47523","journal-title":"J Biol Chem"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.4049\/jimmunol.167.7.3545","volume":"167","author":"Dumoutier L.","year":"2001","unstructured":"Dumoutier L.; Leemans C.; Lejeune D.; Kotenko S.V.; Renauld J.C.; Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol 2001,167(7),3545-3549","journal-title":"J Immunol"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.4049\/jimmunol.168.11.5397","volume":"168","author":"Wolk K.","year":"2002","unstructured":"Wolk K.; Kunz S.; Asadullah K.; Sabat R.; Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 2002,168(11),5397-5402","journal-title":"J Immunol"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.4049\/jimmunol.1700350","volume":"199","author":"Steinert A.","year":"2017","unstructured":"Steinert A.; Linas I.; Kaya B.; Ibrahim M.; Schlitzer A.; Hruz P.; Radulovic K.; Terracciano L.; Macpherson A.J.; Niess J.H.; The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models. J Immunol 2017,199(7),2570-2584","journal-title":"J Immunol"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/ni.2637","volume":"14","author":"Myles I.A.","year":"2013","unstructured":"Myles I.A.; Fontecilla N.M.; Valdez P.A.; Vithayathil P.J.; Naik S.; Belkaid Y.; Ouyang W.; Datta S.K.; Signaling via the IL-20 receptor inhibits cutaneous production of IL-1\u03b2 and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nat Immunol 2013,14(8),804-811","journal-title":"Nat Immunol"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.ebiom.2018.10.031","volume":"37","author":"Madouri F.","year":"2018","unstructured":"Madouri F.; Barada O.; Kervoaze G.; Trottein F.; Pichavant M.; Gosset P.; Production of Interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae. EBioMedicine 2018,37,417-427","journal-title":"EBioMedicine"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/j.1600-0625.2006.00516.x","volume":"15","author":"Kunz S.","year":"2006","unstructured":"Kunz S.; Wolk K.; Witte E.; Witte K.; Doecke W.D.; Volk H.D.; Sterry W.; Asadullah K.; Sabat R.; Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs. Exp Dermatol 2006,15(12),991-1004","journal-title":"Exp Dermatol"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"12704","DOI":"10.1073\/pnas.1117551109","volume":"109","author":"Logsdon N.J.","year":"2012","unstructured":"Logsdon N.J.; Deshpande A.; Harris B.D.; Rajashankar K.R.; Walter M.R.; Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc Natl Acad Sci USA 2012,109(31),12704-12709","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.intimp.2004.01.005","volume":"4","author":"Gallagher G.","year":"2004","unstructured":"Gallagher G.; Eskdale J.; Jordan W.; Peat J.; Campbell J.; Boniotto M.; Lennon G.P.; Dickensheets H.; Donnelly R.P.; Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses. Int Immunopharmacol 2004,4(5),615-626","journal-title":"Int Immunopharmacol"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.ajpath.2015.12.023","volume":"186","author":"Gabunia K.","year":"2016","unstructured":"Gabunia K.; Ellison S.; Kelemen S.; Kako F.; Cornwell W.D.; Rogers T.J.; Datta P.K.; Ouimet M.; Moore K.J.; Autieri M.V.; IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages. Am J Pathol 2016,186(5),1361-1374","journal-title":"Am J Pathol"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.cytogfr.2010.11.001","volume":"21","author":"Sabat R.","year":"2010","unstructured":"Sabat R.; IL-10 family of cytokines. Cytokine Growth Factor Rev 2010,21(5),315-324","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.2174\/138161211798357845","volume":"17","author":"Azuma Y.T.","year":"2011","unstructured":"Azuma Y.T.; Nakajima H.; Takeuchi T.; IL-19 as a potential therapeutic in autoimmune and inflammatory diseases. Curr Pharm Des 2011,17(34),3776-3780","journal-title":"Curr Pharm Des"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1465-9921-14-91","volume":"14","author":"Hackstein H.","year":"2013","unstructured":"Hackstein H.; Kranz S.; Lippitsch A.; Wachtendorf A.; Kershaw O.; Gruber A.D.; Michel G.; Lohmeyer J.; Bein G.; Baal N.; Herold S.; Modulation of respiratory dendritic cells during Klebsiella pneumonia infection. Respir Res 2013,14,91","journal-title":"Respir Res"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1165\/rcmb.2005-0476OC","volume":"35","author":"Zhong H.","year":"2006","unstructured":"Zhong H.; Wu Y.; Belardinelli L.; Zeng D.; A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase. Am J Respir Cell Mol Biol 2006,35(5),587-592","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"6504","DOI":"10.4049\/jimmunol.179.10.6504","volume":"179","author":"Huang F.","year":"2007","unstructured":"Huang F.; Kao C.Y.; Wachi S.; Thai P.; Ryu J.; Wu R.; Requirement for both JAK-mediated PI3K signaling and ACT1\/TRAF6\/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. J Immunol 2007,179(10),6504-6513","journal-title":"J Immunol"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"901","DOI":"10.2353\/ajpath.2008.080163","volume":"173","author":"Tian Y.","year":"2008","unstructured":"Tian Y.; Sommerville L.J.; Cuneo A.; Kelemen S.E.; Autieri M.V.; Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia. Am J Pathol 2008,173(3),901-909","journal-title":"Am J Pathol"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1158\/1078-0432.CCR-11-1532","volume":"18","author":"Hsing C.H.","year":"2012","unstructured":"Hsing C.H.; Cheng H.C.; Hsu Y.H.; Chan C.H.; Yeh C.H.; Li C.F.; Chang M.S.; Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome. Clin Cancer Res 2012,18(3),713-725","journal-title":"Clin Cancer Res"},{"key":"ref=23","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jaci.2008.04.016","volume":"121","author":"Huang F.","year":"2008","unstructured":"Huang F.; Wachi S.; Thai P.; Loukoianov A.; Tan K. H.; Forteza R. M.; Wu R.; Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4\/IL-13: important implications in asthma. J Allergy Clin Immunol e1-32008,121(6),1415-1421","journal-title":"J Allergy Clin Immunol"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1111\/imm.12339","volume":"143","author":"Bao L.","year":"2014","unstructured":"Bao L.; Alexander J.B.; Shi V.Y.; Mohan G.C.; Chan L.S.; Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal transducer and activator of transcription 6 (Stat6) to the imperfect Stat6 sites. Immunology 2014,143(4),601-608","journal-title":"Immunology"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1038\/jid.2014.308","volume":"134","author":"Witte E.","year":"2014","unstructured":"Witte E.; Kokolakis G.; Witte K.; Philipp S.; Doecke W.D.; Babel N.; Wittig B.M.; Warszawska K.; Kurek A.; Erdmann-Keding M.; Kunz S.; Asadullah K.; Kadin M.E.; Volk H.D.; Sterry W.; Wolk K.; Sabat R.; IL-19 is a component of the pathogenetic IL-23\/IL-17 cascade in psoriasis. J Invest Dermatol 2014,134(11),2757-2767","journal-title":"J Invest Dermatol"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"6712","DOI":"10.4049\/jimmunol.173.11.6712","volume":"173","author":"Liao S.C.","year":"2004","unstructured":"Liao S.C.; Cheng Y.C.; Wang Y.C.; Wang C.W.; Yang S.M.; Yu C.K.; Shieh C.C.; Cheng K.C.; Lee M.F.; Chiang S.R.; Shieh J.M.; Chang M.S.; IL-19 induced Th2 cytokines and was up-regulated in asthma patients. J Immunol 2004,173(11),6712-6718","journal-title":"J Immunol"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1002\/eji.200939473","volume":"39","author":"Tohyama M.","year":"2009","unstructured":"Tohyama M.; Hanakawa Y.; Shirakata Y.; Dai X.; Yang L.; Hirakawa S.; Tokumaru S.; Okazaki H.; Sayama K.; Hashimoto K.; IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur J Immunol 2009,39(10),2779-2788","journal-title":"Eur J Immunol"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1254\/jphs.10R02CR","volume":"115","author":"Azuma Y.T.","year":"2011","unstructured":"Azuma Y.T.; Matsuo Y.; Nakajima H.; Yancopoulos G.D.; Valenzuela D.M.; Murphy A.J.; Karow M.; Takeuchi T.; Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection. J Pharmacol Sci 2011,115(2),105-111","journal-title":"J Pharmacol Sci"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.jid.2017.01.007","volume":"137","author":"Hu L.","year":"2017","unstructured":"Hu L.; Mauro T.M.; Dang E.; Man G.; Zhang J.; Lee D.; Wang G.; Feingold K.R.; Elias P.M.; Man M.Q.; Epidermal Dysfunction Leads to an Age-Associated Increase in Levels of Serum\u00a0Inflammatory Cytokines. J Invest Dermatol 2017,137(6),1277-1285","journal-title":"J Invest Dermatol"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"15395","DOI":"10.1038\/ncomms15395","volume":"8","author":"Sidler D.","year":"2017","unstructured":"Sidler D.; Wu P.; Herro R.; Claus M.; Wolf D.; Kawakami Y.; Kawakami T.; Burkly L.; Croft M.; TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis. Nat Commun 2017,8,15395","journal-title":"Nat Commun"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.intimp.2018.12.054","volume":"68","author":"Qian H.","year":"2019","unstructured":"Qian H.; Wang M.; Wang Y.; Ying W.; Zhang J.; Huan Y.; He Y.; Liu Y.; Shi G.; Role of Galphaq in pathogenesis of psoriasis, a new mechanism about the immune regulation in psoriasis. Int Immunopharmacol 2019,68,185-192","journal-title":"Int Immunopharmacol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"105841","DOI":"10.1016\/j.intimp.2019.105841","volume":"75","author":"Xu S.","year":"2019","unstructured":"Xu S.; Zhang X.; Pan M.; Shuai Z.; Xu S.; Pan F.; Treatment of plaque psoriasis with IL-23p19 blockers: A systematic review and meta-analysis. Int Immunopharmacol 2019,75,105841","journal-title":"Int Immunopharmacol"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.intimp.2018.11.031","volume":"66","author":"Huang X.","year":"2019","unstructured":"Huang X.; Yu P.; Liu M.; Deng Y.; Dong Y.; Liu Q.; Zhang J.; Wu T.; ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK\/IL-17 signaling pathway. Int Immunopharmacol 2019,66,236-241","journal-title":"Int Immunopharmacol"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/j.1365-2133.2005.06800.x","volume":"153","author":"Otkjaer K.","year":"2005","unstructured":"Otkjaer K.; Kragballe K.; Funding A.T.; Clausen J.T.; Noerby P.L.; Steiniche T.; Iversen L.; The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis. Br J Dermatol 2005,153(5),911-918","journal-title":"Br J Dermatol"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/j.1523-1747.2003.12626.x","volume":"121","author":"R\u00f8mer J.","year":"2003","unstructured":"R\u00f8mer J.; Hasselager E.; N\u00f8rby P.L.; Steiniche T.; Thorn Clausen J.; Kragballe K.; Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol. J Invest Dermatol 2003,121(6),1306-1311","journal-title":"J Invest Dermatol"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","volume":"136","author":"Noda S.","year":"2015","unstructured":"Noda S.; Su\u00e1rez-Fari\u00f1as M.; Ungar B.; Kim S.J.; de Guzman Strong C.; Xu H.; Peng X.; Estrada Y.D.; Nakajima S.; Honda T.; Shin J.U.; Lee H.; Krueger J.G.; Lee K.H.; Kabashima K.; Guttman-Yassky E.; The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization. J Allergy Clin Immunol 2015,136(5),1254-1264","journal-title":"J Allergy Clin Immunol"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.4049\/jimmunol.178.4.2229","volume":"178","author":"Sa S.M.","year":"2007","unstructured":"Sa S.M.; Valdez P.A.; Wu J.; Jung K.; Zhong F.; Hall L.; Kasman I.; Winer J.; Modrusan Z.; Danilenko D.M.; Ouyang W.; The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol 2007,178(4),2229-2240","journal-title":"J Immunol"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1365-2133.2005.06665.x","volume":"153","author":"Li H.H.","year":"2005","unstructured":"Li H.H.; Lin Y.C.; Chen P.J.; Hsiao C.H.; Lee J.Y.; Chen W.C.; Tzung T.Y.; Wu J.C.; Chang M.S.; Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis. Br J Dermatol 2005,153(3),591-595","journal-title":"Br J Dermatol"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1084\/jem.20060244","volume":"203","author":"Chan J.R.","year":"2006","unstructured":"Chan J.R.; Blumenschein W.; Murphy E.; Diveu C.; Wiekowski M.; Abbondanzo S.; Lucian L.; Geissler R.; Brodie S.; Kimball A.B.; Gorman D.M.; Smith K.; de Waal Malefyt R.; Kastelein R.A.; McClanahan T.K.; Bowman E.P.; IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med 2006,203(12),2577-2587","journal-title":"J Exp Med"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1365-2133.2012.10961.x","volume":"167","author":"Wang F.","year":"2012","unstructured":"Wang F.; Smith N.; Maier L.; Xia W.; Hammerberg C.; Chubb H.; Chen C.; Riblett M.; Johnston A.; Gudjonsson J.E.; Helfrich Y.; Kang S.; Fisher G.J.; Voorhees J.J.; Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24. Br J Dermatol 2012,167(1),92-102","journal-title":"Br J Dermatol"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.4049\/jimmunol.1201505","volume":"190","author":"Johnston A.","year":"2013","unstructured":"Johnston A.; Fritz Y.; Dawes S.M.; Diaconu D.; Al-Attar P.M.; Guzman A.M.; Chen C.S.; Fu W.; Gudjonsson J.E.; McCormick T.S.; Ward N.L.; Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. J Immunol 2013,190(5),2252-2262","journal-title":"J Immunol"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"E5825","DOI":"10.1073\/pnas.1509971112","volume":"112","author":"Johansen C.","year":"2015","unstructured":"Johansen C.; Mose M.; Ommen P.; Bertelsen T.; Vinter H.; Hailfinger S.; Lorscheid S.; Schulze-Osthoff K.; Iversen L.; I\u03baB\u03b6 is a key driver in the development of psoriasis. Proc Natl Acad Sci USA 2015,112(43),E5825-E5833","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.intimp.2018.04.005","volume":"59","author":"Jeong N.H.","year":"2018","unstructured":"Jeong N.H.; Yang E.J.; Jin M.; Lee J.Y.; Choi Y.A.; Park P.H.; Lee S.R.; Kim S.U.; Shin T.Y.; Kwon T.K.; Jang Y.H.; Song K.S.; Kim S.H.; Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines. Int Immunopharmacol 2018,59,209-216","journal-title":"Int Immunopharmacol"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cyto.2012.10.031","volume":"61","author":"Bao L.","year":"2013","unstructured":"Bao L.; Shi V.Y.; Chan L.S.; IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis. Cytokine 2013,61(2),419-425","journal-title":"Cytokine"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.2340\/00015555-2723","volume":"97","author":"Oka T.","year":"2017","unstructured":"Oka T.; Sugaya M.; Takahashi N.; Nakajima R.; Otobe S.; Kabasawa M.; Suga H.; Miyagaki T.; Asano Y.; Sato S.; Increased Interleukin-19 Expression in Cutaneous T-cell Lymphoma and Atopic Dermatitis. Acta Derm Venereol 2017,97(10),1172-1177","journal-title":"Acta Derm Venereol"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1248\/bpb.b17-00594","volume":"41","author":"Fujimoto Y.","year":"2018","unstructured":"Fujimoto Y.; Fujita T.; Kuramoto N.; Kuwamura M.; Izawa T.; Nishiyama K.; Yoshida N.; Nakajima H.; Takeuchi T.; Azuma Y.T.; The Role of Interleukin-19 in Contact Hypersensitivity. Biol Pharm Bull 2018,41(2),182-189","journal-title":"Biol Pharm Bull"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1292\/jvms.19-0149","volume":"81","author":"Fujimoto Y.","year":"2019","unstructured":"Fujimoto Y.; Aono K.; Azuma Y.T.; The clarified role of interleukin-19 in the inflammatory bowel disease and hypersensitivity: Insights from animal models and humans. J Vet Med Sci 2019,81(8),1067-1073","journal-title":"J Vet Med Sci"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"802","DOI":"10.4049\/jimmunol.182.2.802","volume":"182","author":"Wahl C.","year":"2009","unstructured":"Wahl C.; M\u00fcller W.; Leith\u00e4user F.; Adler G.; Oswald F.; Reimann J.; Schirmbeck R.; Seier A.; Weiss J.M.; Prochnow B.; Wegenka U.M.; IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses. J Immunol 2009,182(2),802-810","journal-title":"J Immunol"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"5211","DOI":"10.1038\/s41598-019-41609-z","volume":"9","author":"Konrad R.J.","year":"2019","unstructured":"Konrad R.J.; Higgs R.E.; Rodgers G.H.; Ming W.; Qian Y.W.; Bivi N.; Mack J.K.; Siegel R.W.; Nickoloff B.J.; Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay. Sci Rep 2019,9(1),5211","journal-title":"Sci Rep"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1002\/art.22039","volume":"54","author":"Hsu Y.H.","year":"2006","unstructured":"Hsu Y.H.; Li H.H.; Hsieh M.Y.; Liu M.F.; Huang K.Y.; Chin L.S.; Chen P.C.; Cheng H.H.; Chang M.S.; Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis. Arthritis Rheum 2006,54(9),2722-2733","journal-title":"Arthritis Rheum"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1093\/rheumatology\/ken061","volume":"47","author":"Sakurai N.","year":"2008","unstructured":"Sakurai N.; Kuroiwa T.; Ikeuchi H.; Hiramatsu N.; Maeshima A.; Kaneko Y.; Hiromura K.; Nojima Y.; Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formation. Rheumatology (Oxford) 2008,47(6),815-820","journal-title":"Rheumatology (Oxford)"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/cei.12449","volume":"179","author":"Scrivo R.","year":"2015","unstructured":"Scrivo R.; Conigliaro P.; Riccieri V.; Di Franco M.; Alessandri C.; Spadaro A.; Perricone R.; Valesini G.; Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different contribution to systemic and joint inflammation. Clin Exp Immunol 2015,179(2),300-308","journal-title":"Clin Exp Immunol"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3109\/03009740903170823","volume":"39","author":"Alan\u00e4r\u00e4 T.","year":"2010","unstructured":"Alan\u00e4r\u00e4 T.; Karstila K.; Moilanen T.; Silvennoinen O.; Isom\u00e4ki P.; Expression of IL-10 family cytokines in rheumatoid arthritis: elevated levels of IL-19 in the joints. Scand J Rheumatol 2010,39(2),118-126","journal-title":"Scand J Rheumatol"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.3389\/fimmu.2018.02226","volume":"9","author":"Kragstrup T.W.","year":"2018","unstructured":"Kragstrup T.W.; Andersen T.; Heftdal L.D.; Hvid M.; Gerwien J.; Sivakumar P.; Taylor P.C.; Senolt L.; Deleuran B.; The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis. Front Immunol 2018,9,2226","journal-title":"Front Immunol"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/cei.12577","volume":"180","author":"Kragstrup T.W.","year":"2015","unstructured":"Kragstrup T.W.; Andersen T.; Holm C.; Schi\u00f8ttz-Christensen B.; Jurik A.G.; Hvid M.; Deleuran B.; Toll-like receptor 2 and 4 induced interleukin-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity. Clin Exp Immunol 2015,180(2),233-242","journal-title":"Clin Exp Immunol"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cyto.2007.10.004","volume":"41","author":"Kragstrup T.W.","year":"2008","unstructured":"Kragstrup T.W.; Otkjaer K.; Holm C.; J\u00f8rgensen A.; Hokland M.; Iversen L.; Deleuran B.; The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy. Cytokine 2008,41(1),16-23","journal-title":"Cytokine"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.intimp.2019.05.058","volume":"73","author":"Park S.Y.","year":"2019","unstructured":"Park S.Y.; Lee Y.S.; Lee S.Y.; Lee S.W.; Hong K.W.; Kim C.D.; Multitarget-based cotreatment with cilostazol and celecoxib synergistically suppresses collagen-induced arthritis in mice by enhancing interleukin-10 expression. Int Immunopharmacol 2019,73,461-470","journal-title":"Int Immunopharmacol"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000501163","volume":"104","author":"Li X.","year":"2019","unstructured":"Li X.; Xie P.; Hou Y.; Chen S.; He P.; Xiao Z.; Zhan J.; Luo D.; Gu M.; Lin D.; Tangeretin Inhibits Oxidative Stress and Inflammation via Upregulating Nrf-2 Signaling Pathway in Collagen-Induced Arthritic Rats. Pharmacology 2019,104(3-4),187-195","journal-title":"Pharmacology"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13075-016-0964-7","volume":"18","author":"Kragstrup T.W.","year":"2016","unstructured":"Kragstrup T.W.; Greisen S.R.; Nielsen M.A.; Rhodes C.; Stengaard-Pedersen K.; Hetland M.L.; H\u00f8rslev-Petersen K.; Junker P.; \u00d8stergaard M.; Hvid M.; Vorup-Jensen T.; Robinson W.H.; Sokolove J.; Deleuran B.; The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression. Arthritis Res Ther 2016,18,61","journal-title":"Arthritis Res Ther"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.4049\/jimmunol.169.8.4288","volume":"169","author":"Liao Y.C.","year":"2002","unstructured":"Liao Y.C.; Liang W.G.; Chen F.W.; Hsu J.H.; Yang J.J.; Chang M.S.; IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha. J Immunol 2002,169(8),4288-4297","journal-title":"J Immunol"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1093\/rheumatology\/ker127","volume":"51","author":"Hsu Y.H.","year":"2012","unstructured":"Hsu Y.H.; Hsieh P.P.; Chang M.S.; Interleukin-19 blockade attenuates collagen-induced arthritis in rats. Rheumatology (Oxford) 2012,51(3),434-442","journal-title":"Rheumatology (Oxford)"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.4049\/jimmunol.1600399","volume":"197","author":"Liu X.","year":"2016","unstructured":"Liu X.; Zhou H.; Huang X.; Cui J.; Long T.; Xu Y.; Liu H.; Yu R.; Zhao R.; Luo G.; Huang A.; Liang J.G.; Liang P.; A Broad Blockade of Signaling from the IL-20 Family of Cytokines Potently Attenuates Collagen-Induced Arthritis. J Immunol 2016,197(8),3029-3037","journal-title":"J Immunol"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"8221","DOI":"10.1002\/jcp.27633","volume":"234","author":"Hong X.Y.","year":"2019","unstructured":"Hong X.Y.; Lin J.; Gu W.W.; Risk factors and therapies in vascular diseases: An umbrella review of updated systematic reviews and meta-analyses. J Cell Physiol 2019,234(6),8221-8232","journal-title":"J Cell Physiol"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"21732","DOI":"10.1002\/jcp.28894","volume":"234","author":"Rezaie J.","year":"2019","unstructured":"Rezaie J.; Rahbarghazi R.; Pezeshki M.; Mazhar M.; Yekani F.; Khaksar M.; Shokrollahi E.; Amini H.; Hashemzadeh S.; Sokullu S.E.; Tokac M.; Cardioprotective role of extracellular vesicles: A highlight on exosome beneficial effects in cardiovascular diseases. J Cell Physiol 2019,234(12),21732-21745","journal-title":"J Cell Physiol"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1161\/ATVBAHA.110.207415","volume":"31","author":"Ait-Oufella H.","year":"2011","unstructured":"Ait-Oufella H.; Taleb S.; Mallat Z.; Tedgui A.; Recent advances on the role of cytokines in atherosclerosis. Arterioscler Thromb Vasc Biol 2011,31(5),969-979","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"22242","DOI":"10.1002\/jcp.28792","volume":"234","author":"Mummidi S.","year":"2019","unstructured":"Mummidi S.; Das N.A.; Carpenter A.J.; Yoshida T.; Yariswamy M.; Mostany R.; Izadpanah R.; Higashi Y.; Sukhanov S.; Noda M.; Siebenlist U.; Rector R.S.; Chandrasekar B.; RECK suppresses interleukin-17\/TRAF3IP2-mediated MMP-13 activation and human aortic smooth muscle cell migration and proliferation. J Cell Physiol 2019,234(12),22242-22259","journal-title":"J Cell Physiol"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3389\/fimmu.2018.00700","volume":"9","author":"Autieri M.V.","year":"2018","unstructured":"Autieri M.V.; IL-19 and Other IL-20 Family Member Cytokines in Vascular Inflammatory Diseases. Front Immunol 2018,9,700","journal-title":"Front Immunol"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"253583","DOI":"10.1155\/2012\/253583","volume":"2012","author":"England R.N.","year":"2012","unstructured":"England R.N.; Autieri M.V.; Anti-inflammatory effects of interleukin-19 in vascular disease. Int J Inflamm 2012,2012,253583","journal-title":"Int J Inflamm"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1016\/j.athoracsur.2006.01.092","volume":"81","author":"Hsing C.H.","year":"2006","unstructured":"Hsing C.H.; Hsieh M.Y.; Chen W.Y.; Cheung So E.; Cheng B.C.; Chang M.S.; Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass. Ann Thorac Surg 2006,81(6),2196-2201","journal-title":"Ann Thorac Surg"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.yjmcc.2010.04.016","volume":"49","author":"Cuneo A.A.","year":"2010","unstructured":"Cuneo A.A.; Herrick D.; Autieri M.V.; Il-19 reduces VSMC activation by regulation of mRNA regulatory factor HuR and reduction of mRNA stability. J Mol Cell Cardiol 2010,49(4),647-654","journal-title":"J Mol Cell Cardiol"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1016\/j.ajpath.2014.04.001","volume":"184","author":"Ellison S.","year":"2014","unstructured":"Ellison S.; Gabunia K.; Richards J.M.; Kelemen S.E.; England R.N.; Rudic D.; Azuma Y.T.; Munroy M.A.; Eguchi S.; Autieri M.V.; IL-19 reduces ligation-mediated neointimal hyperplasia by reducing vascular smooth muscle cell activation. Am J Pathol 2014,184(7),2134-2143","journal-title":"Am J Pathol"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1161\/ATVBAHA.118.310929","volume":"38","author":"Ray M.","year":"2018","unstructured":"Ray M.; Gabunia K.; Vrakas C.N.; Herman A.B.; Kako F.; Kelemen S.E.; Grisanti L.A.; Autieri M.V.; Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19\u00d7Ldlr Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R). Arterioscler Thromb Vasc Biol 2018,38(6),1297-1308","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"673","DOI":"10.4330\/wjc.v9.i8.673","volume":"9","author":"Bruns D.R.","year":"2017","unstructured":"Bruns D.R.; Ghincea A.R.; Ghincea C.V.; Azuma Y.T.; Watson P.A.; Autieri M.V.; Walker L.A.; Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World J Cardiol 2017,9(8),673-684","journal-title":"World J Cardiol"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"C255","DOI":"10.1152\/ajpcell.00069.2013","volume":"305","author":"England R.N.","year":"2013","unstructured":"England R.N.; Preston K.J.; Scalia R.; Autieri M.V.; Interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability. Am J Physiol Cell Physiol 2013,305(3),C255-C265","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.celrep.2018.07.002","volume":"24","author":"Herman A.B.","year":"2018","unstructured":"Herman A.B.; Vrakas C.N.; Ray M.; Kelemen S.E.; Sweredoski M.J.; Moradian A.; Haines D.S.; Autieri M.V.; FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells. Cell Rep 2018,24(5),1176-1189","journal-title":"Cell Rep"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1074\/jbc.M111.312470","volume":"287","author":"Gabunia K.","year":"2012","unstructured":"Gabunia K.; Ellison S.P.; Singh H.; Datta P.; Kelemen S.E.; Rizzo V.; Autieri M.V.; Interleukin-19 (IL-19) induces heme oxygenase-1 (HO-1) expression and decreases reactive oxygen species in human vascular smooth muscle cells. J Biol Chem 2012,287(4),2477-2484","journal-title":"J Biol Chem"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/bph.14549","volume":"176","author":"An W.","year":"2019","unstructured":"An W.; Yu Y.; Zhang Y.; Zhang Z.; Yu Y.; Zhao X.; Exogenous IL-19 attenuates acute ischaemic injury and improves survival in male mice with myocardial infarction. Br J Pharmacol 2019,176(5),699-710","journal-title":"Br J Pharmacol"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1093\/ibd\/izy230","volume":"24","author":"Porter R.J.","year":"2018","unstructured":"Porter R.J.; Andrews C.; Brice D.P.; Durum S.K.; McLean M.H.; Can We Target Endogenous Anti-inflammatory Responses as a Therapeutic Strategy for Inflammatory Bowel Disease? Inflamm Bowel Dis 2018,24(10),2123-2134","journal-title":"Inflamm Bowel Dis"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1093\/ibd\/izy030","volume":"24","author":"Egberg M.D.","year":"2018","unstructured":"Egberg M.D.; Gulati A.S.; Gellad Z.F.; Melmed G.Y.; Kappelman M.D.; Improving Quality in the Care of Patients with Inflammatory Bowel Diseases. Inflamm Bowel Dis 2018,24(8),1660-1669","journal-title":"Inflamm Bowel Dis"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1002\/jcp.27173","volume":"234","author":"Moein S.","year":"2019","unstructured":"Moein S.; Vaghari-Tabari M.; Qujeq D.; Majidinia M.; Nabavi S.M.; Yousefi B.; MiRNAs and inflammatory bowel disease: An interesting new story. J Cell Physiol 2019,234(4),3277-3293","journal-title":"J Cell Physiol"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/cei.12285","volume":"177","author":"Fonseca-Camarillo G.","year":"2014","unstructured":"Fonseca-Camarillo G.; Furuzawa-Carballeda J.; Granados J.; Yamamoto-Furusho J.K.; Expression of interleukin (IL)-19 and IL-24 in inflammatory bowel disease patients: a cross-sectional study. Clin Exp Immunol 2014,177(1),64-75","journal-title":"Clin Exp Immunol"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.humimm.2011.08.013","volume":"72","author":"Yamamoto-Furusho J.K.","year":"2011","unstructured":"Yamamoto-Furusho J.K.; \u00c1lvarez-Le\u00f3n E.; Fragoso J.M.; Gozalishvilli A.; Vallejo M.; Vargas-Alarc\u00f3n G.; Protective role of interleukin-19 gene polymorphisms in patients with ulcerative colitis. Hum Immunol 2011,72(11),1029-1032","journal-title":"Hum Immunol"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"e93910","DOI":"10.1371\/journal.pone.0093910","volume":"9","author":"Cant\u00f3 E.","year":"2014","unstructured":"Cant\u00f3 E.; Garcia Planella E.; Zamora-Atenza C.; Nieto J.C.; Gordillo J.; Ortiz M.A.; Met\u00f3n I.; Serrano E.; Vegas E.; Garc\u00eda-Bosch O.; Ju\u00e1rez C.; Vidal S.; Interleukin-19 impairment in active Crohn\u2019s disease patients. PLoS One 2014,9(4),e93910","journal-title":"PLoS One"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nm1720","volume":"14","author":"Zheng Y.","year":"2008","unstructured":"Zheng Y.; Valdez P.A.; Danilenko D.M.; Hu Y.; Sa S.M.; Gong Q.; Abbas A.R.; Modrusan Z.; Ghilardi N.; de Sauvage F.J.; Ouyang W.; Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 2008,14(3),282-289","journal-title":"Nat Med"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.3389\/fimmu.2018.01373","volume":"18","author":"Niess J.H.","year":"2018","unstructured":"Niess J.H.; Hruz P.; Kaymak T.; The Interleukin-20 Cytokines in Intestinal Diseases. Front Immunol 2018,18(9),1373","journal-title":"Front Immunol"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/ibd.21151","volume":"16","author":"Azuma Y.T.","year":"2010","unstructured":"Azuma Y.T.; Matsuo Y.; Kuwamura M.; Yancopoulos G.D.; Valenzuela D.M.; Murphy A.J.; Nakajima H.; Karow M.; Takeuchi T.; Interleukin-19 protects mice from innate-mediated colonic inflammation. Inflamm Bowel Dis 2010,16(6),1017-1028","journal-title":"Inflamm Bowel Dis"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.intimp.2015.10.011","volume":"29","author":"Matsuo Y.","year":"2015","unstructured":"Matsuo Y.; Azuma Y.T.; Kuwamura M.; Kuramoto N.; Nishiyama K.; Yoshida N.; Ikeda Y.; Fujimoto Y.; Nakajima H.; Takeuchi T.; Interleukin 19 reduces inflammation in chemically induced experimental colitis. Int Immunopharmacol 2015,29(2),468-475","journal-title":"Int Immunopharmacol"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00210-016-1329-0","volume":"390","author":"Fujimoto Y.","year":"2017","unstructured":"Fujimoto Y.; Azuma Y.T.; Matsuo Y.; Kuwamura M.; Kuramoto N.; Miki M.; Azuma N.; Teramoto M.; Nishiyama K.; Izawa T.; Nakajima H.; Takeuchi T.; Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis. Naunyn Schmiedebergs Arch Pharmacol 2017,390(3),261-268","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jhep.2006.08.009","volume":"46","author":"Wegenka U.M.","year":"2007","unstructured":"Wegenka U.M.; Dikopoulos N.; Reimann J.; Adler G.; Wahl C.; The murine liver is a potential target organ for IL-19, IL-20 and IL-24: Type I Interferons and LPS regulate the expression of IL-20R2. J Hepatol 2007,46(2),257-265","journal-title":"J Hepatol"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"e56028","DOI":"10.1371\/journal.pone.0056028","volume":"8","author":"Hsu Y.H.","year":"2013","unstructured":"Hsu Y.H.; Li H.H.; Sung J.M.; Chen W.T.; Hou Y.C.; Chang M.S.; Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. PLoS One 2013,8(2),e56028","journal-title":"PLoS One"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"684237","DOI":"10.1155\/2013\/684237","volume":"2013","author":"Mehta R.","year":"2013","unstructured":"Mehta R.; Birerdinc A.; Neupane A.; Shamsaddini A.; Afendy A.; Elariny H.; Chandhoke V.; Baranova A.; Younossi Z.M.; Expression of inflammation-related genes is altered in gastric tissue of patients with advanced stages of NAFLD. Mediators Inflamm 2013,2013,684237","journal-title":"Mediators Inflamm"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/hep.27189","volume":"60","author":"Chiu Y.S.","year":"2014","unstructured":"Chiu Y.S.; Wei C.C.; Lin Y.J.; Hsu Y.H.; Chang M.S.; IL-20 and IL-20R1 antibodies protect against liver fibrosis. Hepatology 2014,60(3),1003-1014","journal-title":"Hepatology"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1002\/hep.25744","volume":"56","author":"Kong X.","year":"2012","unstructured":"Kong X.; Feng D.; Wang H.; Hong F.; Bertola A.; Wang F.S.; Gao B.; Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology 2012,56(3),1150-1159","journal-title":"Hepatology"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"3500","DOI":"10.1002\/jcp.26863","volume":"234","author":"Huang S.","year":"2019","unstructured":"Huang S.; Zhou D.; Li Y.X.; Ming Z.Y.; Li K.Z.; Wu G.B.; Chen C.; Zhao Y.N.; In vivo and in vitro effects of microRNA-221 on hepatocellular carcinoma development and progression through the JAK-STAT3 signaling pathway by targeting SOCS3. J Cell Physiol 2019,234(4),3500-3514","journal-title":"J Cell Physiol"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.brainres.2016.09.006","volume":"1650","author":"Xie W.","year":"2016","unstructured":"Xie W.; Fang L.; Gan S.; Xuan H.; Interleukin-19 alleviates brain injury by anti-inflammatory effects in a mice model of focal cerebral ischemia. Brain Res 2016,1650,172-177","journal-title":"Brain Res"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1111\/bph.14193","volume":"175","author":"Guo J.","year":"2018","unstructured":"Guo J.; Wang H.; Li L.; Yuan Y.; Shi X.; Hou S.; Treatment with IL-19 improves locomotor functional recovery after contusion trauma to the spinal cord. Br J Pharmacol 2018,175(13),2611-2621","journal-title":"Br J Pharmacol"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"e0118640","DOI":"10.1371\/journal.pone.0118640","volume":"10","author":"Horiuchi H.","year":"2015","unstructured":"Horiuchi H.; Parajuli B.; Wang Y.; Azuma Y.T.; Mizuno T.; Takeuchi H.; Suzumura A.; Interleukin-19 acts as a negative autocrine regulator of activated microglia. PLoS One 2015,10(3),e0118640","journal-title":"PLoS One"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1002\/glia.22644","volume":"62","author":"Cooley I.D.","year":"2014","unstructured":"Cooley I.D.; Chauhan V.S.; Donneyz M.A.; Marriott I.; Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member. Glia 2014,62(5),818-828","journal-title":"Glia"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12974-019-1444-1","volume":"16","author":"Burmeister A.R.","year":"2019","unstructured":"Burmeister A.R.; Johnson M.B.; Yaemmongkol J.J.; Marriott I.; Murine astrocytes produce IL-24 and are susceptible to the immunosuppressive effects of this cytokine. J Neuroinflammation 2019,16(1),55","journal-title":"J Neuroinflammation"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"134334","DOI":"10.1016\/j.neulet.2019.134334","volume":"708","author":"Burmeister A.R.","year":"2019","unstructured":"Burmeister A.R.; Johnson M.B.; Marriott I.; Murine astrocytes are responsive to the pro-inflammatory effects of IL-20. Neurosci Lett 2019,708,134334","journal-title":"Neurosci Lett"}],"container-title":["Current Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/181306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/181306\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/181306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T22:56:22Z","timestamp":1746572182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/181306\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,12,31]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1874467213666200424151528","relation":{},"ISSN":["1874-4672"],"issn-type":[{"value":"1874-4672","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,31]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}