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Much\nevidence strongly suggests that sirtuin1, which is the key factor to regulate mitochondrial activity,\nmay be implicated in MDD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Since it is suggested that royal jelly (RJ) ameliorated depressive-like behavior and\naffected mitochondrial activity in mice, we hypothesized RJ could be an alternative medicine against\nMDD which acts via sirtuin1 signaling to improve mitochondrial activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> In the present study, we applied a mouse model of MDD to investigate the effect of RJ on\nthe depressive-like behavior and the sirtuin1 signaling on mitochondrial activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Our results indicated that either the oral administration of RJ for 12 days or single\nintracerebroventricular (i.c.v.) injection decreased the duration of immobility in the tail suspension\ntest, which suggested that RJ had an antidepressant-like effect. Moreover, sirtuin1 protein expression\nincreased in mice following RJ treatment in the amygdala region, but not in the other brain regions.\nSimilarly, the expressions of oxidative phosphorylation (OXPHOS) related proteins increased in the\namygdala regions, but not in the hippocampal regions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> The increase of sirtuin1 and OXPHOS protein expression may at least in part contribute\nto the antidepressant-like effect of the RJ pathway, and RJ may have the potential to be a novel antidepressant drug. <\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874467213666200424160153","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T15:26:56Z","timestamp":1587742016000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic Royal Jelly Administration Induced Antidepressant-Like Effects Through Increased Sirtuin1 and Oxidative Phosphorylation Protein Expression in the Amygdala of Mice"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6880-8757","authenticated-orcid":true,"given":"Thanh Trung","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-0628","authenticated-orcid":true,"given":"Yuki","family":"Kambe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3959-331X","authenticated-orcid":true,"given":"Atsuro","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima890-8544, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrn3229","volume":"13","author":"Manji H.","year":"2012","unstructured":"Manji H.; Kato T.; Di Prospero N. 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