{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:07:40Z","timestamp":1783008460547,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology-Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2018\/000051"],"award-info":[{"award-number":["CRG\/2018\/000051"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"SRM Institute of Science and Technology, the Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR15014\/BRB\/10\/1481\/2016"],"award-info":[{"award-number":["BT\/PR15014\/BRB\/10\/1481\/2016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMP"],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Recent reports have unveiled the potential of flavonoids to enhance bone formation and assuage\nbone resorption due to their involvement in cell signaling pathways. They also act as an effective alternative to circumvent\nthe disadvantages associated with existing treatment methods, which has increased their scope in orthopedic research.\nValproic acid (VA, 2-propylpentanoic acid) is one such flavonoid, obtained from an herbaceous plant, used in the\ntreatment of epilepsy and various types of seizures.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>In this study, the role of VA in osteogenesis and the molecular mechanisms underpinning its action in mouse\nmesenchymal stem cells (mMSCs) were determined.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods &amp; Results:<\/jats:title>\n<jats:p> Cytotoxic studies validated VA\u2019s amiable nature in mMSCs. Alizarin red and von Kossa staining\nresults showed an increased deposition of calcium phosphate in VA-treated mMSCs, which confirmed the occurrence of\nosteoblast differentiation and mineralization at a cellular level. At the molecular level, there were increased levels of\nexpression of Runx2, a vital bone transcription factor, and other major osteoblast differentiation marker genes in the VAtreated mMSCs. Further, VA-treatment in mMSCs upregulated mir-21 and activated the mitogen-activated protein\nkinase\/extracellular signal-regulated kinase signaling pathway, which might be essential for the expression\/activity of\nRunx2.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Thus, the current study confirmed the osteoinductive nature of VA at the cellular and molecular levels,\nopening the possibility for its application in bone therapeutics with mir-21.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874467213666200713102410","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T06:12:21Z","timestamp":1594707141000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells"],"prefix":"10.1016","volume":"14","author":[{"given":"Narayanan","family":"Akshaya","sequence":"first","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Prasith","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakrishnan","family":"Abinaya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badrinath","family":"Ashwin","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.V.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-1920","authenticated-orcid":true,"given":"Nagarajan","family":"Selvamurugan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"ref=1","author":"Seeman E.","year":"2008","unstructured":"Seeman E.;  Modeling and remodeling Principles of Bone Biology 2008","journal-title":"Modeling and remodeling Principles of Bone Biology"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"e1900171","DOI":"10.1002\/biot.201900171","volume":"14","author":"Abinaya B.","year":"2019","unstructured":"Abinaya B.; Prasith T.P.; Ashwin B.; Viji Chandran S.; Selvamurugan N.; Chitosan in Surface Modification for Bone Tissue Engineering Applications. Biotechnol J 2019,14(12),e1900171","journal-title":"Biotechnol J"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1016\/j.ijbiomac.2016.12.046","volume":"104","author":"Balagangadharan K.","year":"2017","unstructured":"Balagangadharan K.; Dhivya S.; Selvamurugan N.; Chitosan based nanofibers in bone tissue engineering. Int J Biol Macromol 2017,104(Pt B),1372-1382","journal-title":"Int J Biol Macromol"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41574-019-0246-y","volume":"15","author":"Dirckx N.","year":"2019","unstructured":"Dirckx N.; Moorer M.C.; Clemens T.L.; Riddle R.C.; The role of osteoblasts in energy homeostasis. Nat Rev Endocrinol 2019,15(11),651-665","journal-title":"Nat Rev Endocrinol"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13287-020-1581-6","author":"Hu Z.","year":"2020","unstructured":"Hu Z.; Zhang L.; Wang H.; Wang Y.; Tan Y.; Dang L.; Wang K.; Sun Z.; Li G.; Cao X.; Zhang S.; Targeted silencing of miRNA-132-3p expression rescues disuse osteopenia by promoting mesenchymal stem cell osteogenic differentiation and osteogenesis in mice Stem Cell Res Ther 2020,58","journal-title":"Stem Cell Res Ther"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","volume":"6","author":"Feng X.","year":"2011","unstructured":"Feng X.; McDonald J.M.; Disorders of bone remodeling. Annu Rev Pathol 2011,6,121-145","journal-title":"Annu Rev Pathol"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ijbiomac.2017.09.014","volume":"110","author":"Preethi Soundarya S.","year":"2018","unstructured":"Preethi Soundarya S.; Sanjay V.; Haritha Menon A.; Dhivya S.; Selvamurugan N.; Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering. Int J Biol Macromol 2018,110,74-87","journal-title":"Int J Biol Macromol"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00109-013-1084-3","volume":"92","author":"Crane J.L.","year":"2014","unstructured":"Crane J.L.; Cao X.; Function of matrix IGF-1 in coupling bone resorption and formation. J Mol Med (Berl) 2014,92(2),107-115","journal-title":"J Mol Med (Berl)"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1385\/1-59259-863-3:113","author":"Trippel S.B.","year":"2005","unstructured":"Trippel S.B.;  Bone Regeneration and Repair 2005,113-132","journal-title":"Bone Regeneration and Repair"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.lfs.2018.09.053","volume":"212","author":"Zhou L.","year":"2018","unstructured":"Zhou L.; Zhang T.; Sun S.; Yu Y.; Wang M.; Cryptochrome 1 promotes osteogenic differentiation of human osteoblastic cells via Wnt\/\u03b2-Catenin signaling. Life Sci 2018,212,129-137","journal-title":"Life Sci"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1359\/jbmr.070701","volume":"22","author":"Duque G.","year":"2007","unstructured":"Duque G.; Rivas D.; Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells. J Bone Miner Res 2007,22(10),1603-1611","journal-title":"J Bone Miner Res"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/biof.1515","volume":"45","author":"Srinaath N.","year":"2019","unstructured":"Srinaath N.; Balagangadharan K.; Pooja V.; Paarkavi U.; Trishla A.; Selvamurugan N.; Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells. Biofactors 2019,45(4),575-582","journal-title":"Biofactors"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.carbpol.2019.04.002","volume":"216","author":"Balagangadharan K.","year":"2019","unstructured":"Balagangadharan K.; Trivedi R.; Vairamani M.; Selvamurugan N.; Sinapic acid-loaded chitosan nanoparticles in polycaprolactone electrospun fibers for bone regeneration in vitro and in vivo. Carbohydr Polym 2019,216,1-16","journal-title":"Carbohydr Polym"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"108750","DOI":"10.1016\/j.cbi.2019.108750","volume":"310","author":"Shanmugam H.","year":"2019","unstructured":"Shanmugam H.; Dharun V.N.; Biswal B.K.; Chandran S.V.; Vairamani M.; Selvamurugan N.; Osteogenic stimulatory effect of heraclenin purified from bael in mouse mesenchymal stem cells in vitro. Chem Biol Interact 2019,310,108750","journal-title":"Chem Biol Interact"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.M101287200","volume":"276","author":"Phiel C.J.","year":"2001","unstructured":"Phiel C.J.; Zhang F.; Huang E.Y.; Guenther M.G.; Lazar M.A.; Klein P.S.; Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 2001,276(39),36734-36741","journal-title":"J Biol Chem"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"479364","DOI":"10.1155\/2010\/479364","volume":"2010","author":"Chateauvieux S.","year":"2010","unstructured":"Chateauvieux S.; Morceau F.; Dicato M.; Diederich M.; Molecular and therapeutic potential and toxicity of valproic acid. J Biomed Biotechnol 2010,2010,479364","journal-title":"J Biomed Biotechnol"},{"key":"ref=17","first-page":"7","volume":"15","author":"Vimalraj S.","year":"2013","unstructured":"Vimalraj S.; Selvamurugan N.; MicroRNAs: synthesis, gene regulation and osteoblast differentiation. Curr Issues Mol Biol 2013,15(1),7-18","journal-title":"Curr Issues Mol Biol"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1155\/2013\/451248","volume":"35","author":"Vimalraj S.","year":"2013","unstructured":"Vimalraj S.; Miranda P.J.; Ramyakrishna B.; Selvamurugan N.; Regulation of breast cancer and bone metastasis by microRNAs. Dis Markers 2013,35(5),369-387","journal-title":"Dis Markers"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbacli.2014.11.009","volume":"3","author":"Song J.","year":"2014","unstructured":"Song J.; Jin E.H.; Kim D.; Kim K.Y.; Chun C.H.; Jin E.J.; MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis. BBA Clin 2014,3,79-89","journal-title":"BBA Clin"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"e43800","DOI":"10.1371\/journal.pone.0043800","volume":"7","author":"Okamoto H.","year":"2012","unstructured":"Okamoto H.; Matsumi Y.; Hoshikawa Y.; Takubo K.; Ryoke K.; Shiota G.; Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. PLoS One 2012,7(8),e43800","journal-title":"PLoS One"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"356","DOI":"10.2174\/1389203720666181031143129","volume":"20","author":"Shreya S.","year":"2019","unstructured":"Shreya S.; Malavika D.; Priya V.R.; Selvamurugan N.; Regulation of Histone Deacetylases by MicroRNAs in Bone. Curr Protein Pept Sci 2019,20(4),356-367","journal-title":"Curr Protein Pept Sci"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.biochi.2018.12.006","volume":"158","author":"Arumugam B.","year":"2019","unstructured":"Arumugam B.; Vishal M.; Shreya S.; Malavika D.; Rajpriya V.; He Z.; Partridge N.C.; Selvamurugan N.; Parathyroid hormone-stimulation of Runx2 during osteoblast differentiation via the regulation of lnc-SUPT3H-1:16 (RUNX2-AS1:32) and miR-6797-5p. Biochimie 2019,158,43-52","journal-title":"Biochimie"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12951-015-0099-z","volume":"13","author":"Dhivya S.","year":"2015","unstructured":"Dhivya S.; Saravanan S.; Sastry T.P.; Selvamurugan N.; Nanohydroxyapatite-reinforced chitosan composite hydrogel for bone tissue repair in vitro and in vivo. J Nanobiotechnology 2015,13(1),40","journal-title":"J Nanobiotechnology"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.carbpol.2018.04.115","volume":"195","author":"Menon A.H.","year":"2018","unstructured":"Menon A.H.; Soundarya S.P.; Sanjay V.; Chandran S.V.; Balagangadharan K.; Selvamurugan N.; Sustained release of chrysin from chitosan-based scaffolds promotes mesenchymal stem cell proliferation and osteoblast differentiation. Carbohydr Polym 2018,195,356-367","journal-title":"Carbohydr Polym"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s12079-018-0449-3","volume":"12","author":"Arumugam B.","year":"2018","unstructured":"Arumugam B.; Balagangadharan K.; Selvamurugan N.; Syringic acid, a phenolic acid, promotes osteoblast differentiation by stimulation of Runx2 expression and targeting of Smad7 by miR-21 in mouse mesenchymal stem cells. J Cell Commun Signal 2018,12(3),561-573","journal-title":"J Cell Commun Signal"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/jcp.25434","volume":"232","author":"Vishal M.","year":"2017","unstructured":"Vishal M.; Vimalraj S.; Ajeetha R.; Gokulnath M.; Keerthana R.; He Z.; Partridge N.C.; Selvamurugan N.; MicroRNA-590-5p Stabilizes Runx2 by Targeting Smad7 During Osteoblast Differentiation. J Cell Physiol 2017,232(2),371-380","journal-title":"J Cell Physiol"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"2450327","DOI":"10.1155\/2017\/2450327","volume":"2017","author":"Selvamurugan N.","year":"2017","unstructured":"Selvamurugan N.; He Z.; Rifkin D.; Dabovic B.; Partridge N.C.; Pulsed electromagnetic field regulates MicroRNA 21 expression to activate TGF-\u03b2 signaling in human bone marrow stromal cells to enhance osteoblast differentiation. Stem Cells Int 2017,2017,2450327","journal-title":"Stem Cells Int"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"116676","DOI":"10.1016\/j.lfs.2019.116676","volume":"232","author":"Narayanan A.","year":"2019","unstructured":"Narayanan A.; Srinaath N.; Rohini M.; Selvamurugan N.; Regulation of Runx2 by MicroRNAs in osteoblast differentiation. Life Sci 2019,232,116676","journal-title":"Life Sci"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1002\/jcb.24479","volume":"114","author":"Mei Y.","year":"2013","unstructured":"Mei Y.; Bian C.; Li J.; Du Z.; Zhou H.; Yang Z.; Zhao R.C.; miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation. J Cell Biochem 2013,114(6),1374-1384","journal-title":"J Cell Biochem"},{"key":"ref=30","doi-asserted-by":"publisher","DOI":"10.4137\/DTI.S6534","author":"Hatakeyama Y.","year":"2011","unstructured":"Hatakeyama Y.; Hatakeyama J.; Takahashi A.; Oka K.; Tsuruga E.; Inai T.; Sawa Y.; The effect of valproic Acid on mesenchymal pluripotent cell proliferation and differentiation in extracellular matrices Drug Target Insights 2011","journal-title":"Drug Target Insights"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1359\/JBMR.050813","volume":"20","author":"Schroeder T.M.","year":"2005","unstructured":"Schroeder T.M.; Westendorf J.J.; Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res 2005,20(12),2254-2263","journal-title":"J Bone Miner Res"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/B978-0-12-800018-2.00008-X","author":"McGaw L.J.","year":"2014","unstructured":"McGaw L.J.; Elgorashi E.E.; Eloff J.N.;  Toxicological Survey of African Medicinal Plants 2014,181-233","journal-title":"Toxicological Survey of African Medicinal Plants"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/33.1.2578146","volume":"33","author":"Jones K.H.","year":"1985","unstructured":"Jones K.H.; Senft J.A.; An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide. J Histochem Cytochem 1985,33(1),77-79","journal-title":"J Histochem Cytochem"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/0011-2240(75)90048-6","volume":"12","author":"McGrath J.J.","year":"1975","unstructured":"McGrath J.J.; Cravalho E.G.; Huggins C.E.; An experimental comparison of intracellular ice formation and freeze-thaw survival of HeLa S-3 cells. Cryobiology 1975,12(6),540-550","journal-title":"Cryobiology"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ab.2004.02.002","volume":"329","author":"Gregory C.A.","year":"2004","unstructured":"Gregory C.A.; Gunn W.G.; Peister A.; Prockop D.J.; An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem 2004,329(1),77-84","journal-title":"Anal Biochem"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/art.1780260211","volume":"26","author":"Paul H.","year":"1983","unstructured":"Paul H.; Reginato A.J.; Schumacher H.R.; Alizarin red S staining as a screening test to detect calcium compounds in synovial fluid. Arthritis Rheum 1983,26(2),191-200","journal-title":"Arthritis Rheum"},{"key":"ref=37","first-page":"12814","author":"Cao L.","year":"2020","unstructured":"Cao L.; Liu W.; Zhong Y.; Zhang Y.; Gao D.; He T.; Liu Y.; Zou Z.; Mo Y.; Peng S.; Shuai C.;  Linc02349 promotes osteogenesis of human umbilical cord-derived stem cells by acting as a competing endogenous RNA for miR-25-3p and miR-33b-5p 2020,12814","journal-title":"Linc02349 promotes osteogenesis of human umbilical cord-derived stem cells by acting as a competing endogenous RNA for miR-25-3p and miR-33b-5p"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1007\/BF00157809","volume":"25","author":"Rungby J.","year":"1993","unstructured":"Rungby J.; Kassem M.; Eriksen E.F.; Danscher G.; The von Kossa reaction for calcium deposits: silver lactate staining increases sensitivity and reduces background. Histochem J 1993,25(6),446-451","journal-title":"Histochem J"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00441-009-0832-8","volume":"339","author":"Komori T.","year":"2010","unstructured":"Komori T.; Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res 2010,339(1),189-195","journal-title":"Cell Tissue Res"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1097\/BCO.0b013e3282630851","volume":"18","author":"Golub E.E.","year":"2007","unstructured":"Golub E.E.; Boesze-Battaglia K.; The role of alkaline phosphatase in mineralization. Curr Opin Orthop 2007,18(5),444-448","journal-title":"Curr Opin Orthop"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/jcp.10395","volume":"198","author":"B\u00fcttner C.","year":"2004","unstructured":"B\u00fcttner C.; Skupin A.; Rieber E.P.; Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin-4: analysis of the functional collagen promoter sequences. J Cell Physiol 2004,198(2),248-258","journal-title":"J Cell Physiol"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0378-1119(88)90013-3","volume":"67","author":"D\u2019Alessio M.","year":"1988","unstructured":"D\u2019Alessio M.; Bernard M.; Pretorius P.J.; de Wet W.; Ramirez F.; Complete nucleotide sequence of the region encompassing the first twenty-five exons of the human pro \u03b1 1(I) collagen gene (COL1A1). Gene 1988,67(1),105-115","journal-title":"Gene"},{"key":"ref=43","first-page":"127137","author":"Ganesh S.","year":"2020","unstructured":"Ganesh S.; D. Saleth Sidharthan, S. Pranavkrishna, S. Pranavadithya, R. Abhinandan, R. L. Akshaya, K. Balagangadharan, Nishitha Siddabathuni, Swathi Srinivasan, and N. Selvamurugan. An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1\/2) towards osteoblasts. Bioorg Med Chem Lett 2020,127137","journal-title":"Bioorg Med Chem Lett"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s11101-017-9529-x","volume":"16","author":"Torre E.","year":"2017","unstructured":"Torre E.; Molecular signaling mechanisms behind polyphenol-induced bone anabolism. Phytochem Rev 2017,16(6),1183-1226","journal-title":"Phytochem Rev"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-48429-1","volume":"9","author":"Chandran S.","year":"2019","unstructured":"Chandran S.; Viji, M. Vairamani, and N. Selvamurugan. Osteostimulatory effect of biocomposite scaffold containing phytomolecule diosmin by Integrin\/FAK\/ERK signaling pathway in mouse mesenchymal stem cells. Sci Rep 2019,9(1),1-13","journal-title":"Sci Rep"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.jsbmb.2014.08.002","volume":"144","author":"Xiao H-H.","year":"2014","unstructured":"Xiao H-H.; Gao Q-G.; Zhang Y.; Wong K-C.; Dai Y.; Yao X-S.; Wong M-S.; Vanillic acid exerts oestrogen-like activities in osteoblast-like UMR 106 cells through MAP kinase (MEK\/ERK)-mediated ER signaling pathway. J Steroid Biochem Mol Biol 2014,144(Pt B),382-391","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejphar.2013.05.039","volume":"714","author":"Song L.","year":"2013","unstructured":"Song L.; Zhao J.; Zhang X.; Li H.; Zhou Y.; Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation. Eur J Pharmacol 2013,714(1-3),15-22","journal-title":"Eur J Pharmacol"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s40610-017-0059-5","volume":"3","author":"Franceschi R.T.","year":"2017","unstructured":"Franceschi R.T.; Ge C.; Control of the Osteoblast Lineage by Mitogen-Activated Protein Kinase Signaling. Curr Mol Biol Rep 2017,3(2),122-132","journal-title":"Curr Mol Biol Rep"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1083\/jcb.200610046","volume":"176","author":"Ge C.","year":"2007","unstructured":"Ge C.; Xiao G.; Jiang D.; Franceschi R.T.; Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 2007,176(5),709-718","journal-title":"J Cell Biol"}],"container-title":["Current Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/183698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/183698\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/183698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T22:57:02Z","timestamp":1746572222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/183698\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12,31]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1874467213666200713102410","relation":{},"ISSN":["1874-4672"],"issn-type":[{"value":"1874-4672","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,31]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}