{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:00:29Z","timestamp":1774573229198,"version":"3.50.1"},"reference-count":0,"publisher":"Elsevier BV","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMP"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Piperine is a key bioactive alkaloid found in plants of piperaceae family.\nThe compound possesses various medicinal and pharmacological activities (cholesterol-lowering,\nanti-cancer, Alzheimer\u2019s disease etc.). Owing to its various target receptors (TRPV1, P-gp,\nCYP3A4 etc.) and several mechanisms, piperine has been studied as bio-enhancer for other drugs\nand its role has been evidenced in the literature. When administered with other drugs, it increases\nthe absorption of other drugs, thereby reducing the dose and dose-related toxic potential. There are\nvarious mechanisms of piperine as a bio-enhancer and the common ones are i) prevention of efflux\nof drug molecules out of the cells; ii) decreased metabolism of drugs, thereby prolonging the halflife\nof drugs resulting in reduced urinary excretion. The detailed mechanism indicating the bio-enhancing\nrole of piperine along with various target receptors has not been comprehensively summarised\nto date.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Literature related to the molecular, enzymatic and receptor targets of piperine were studied and database was\ncollected using various search engines such as j-gate, google scholar, scihub, pubmed, sciencedirect etc. The literature\nrelated to therapeutic activities of piperine and its bio-enhancer role for other drugs has been thoroughly studied and\ncompiled in brief.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>A detailed summary of piperine targets along with related mechanisms has been stated. A brief therapeutic\nprofile of piperine alone has been produced with supporting literature. Piperine role as a potential bio-enhancer for other\ndrugs has been summarized.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Piperine is a fascinating molecule of natural origin with several modes of its action,\nnot only possesses its own therapeutic activity but also enhances the therapeutic efficacy of other\nsynthetic and natural drug molecules. Combination dosage forms of various API incorporating\npiperine as a bio-enhancer can be a potential area of thrust for upcoming drug design and development.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874467213666200722152636","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T06:29:58Z","timestamp":1595572198000},"page":"477-486","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Propitious Profile of Peppery Piperine"],"prefix":"10.1016","volume":"14","author":[{"given":"Harman","family":"Bakshi","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-6743","authenticated-orcid":true,"given":"Manju","family":"Nagpal","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-2790","authenticated-orcid":true,"given":"Gitika A.","family":"Dhingra","sequence":"additional","affiliation":[{"name":"NCRD\u2019S Sterling Institute of Pharmacy, Navi Mumbai,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-7018","authenticated-orcid":true,"given":"Geeta","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Delhi Pharmaceutical Sciences and Research University, New Delhi-110017,India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","container-title":["Current Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download\/184044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/184044\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download\/184044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T22:57:02Z","timestamp":1746572222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/184044\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1874467213666200722152636","relation":{},"ISSN":["1874-4672"],"issn-type":[{"value":"1874-4672","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}