{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:37:07Z","timestamp":1790854627875,"version":"4.1.0"},"reference-count":0,"publisher":"Elsevier BV","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMP"],"published-print":{"date-parts":[[2021,12,16]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Tissue cells of the eye are sensitive to oxidative stress, leading to oxidative damage and\ninflammation, which have crucial roles in the pathogenesis of most of the eye diseases. Moreover,\nfactors such as age, angiogenesis, ischemia, genetic predisposition, diabetes, obesity, and smoking\naffect the onset and progression of ocular anomalies. Major eye diseases are either age-related such\nas age-related macular degeneration, cataracts, diabetic retinopathy, glaucoma, dry eye, or inflammatory\neye diseases such as blepharitis, conjunctivitis, uveitis and other retinal pathologies, which\ncan cause ocular damage and visual problems through oxidative stress, inflammation pathways. Although\nthere are conventional chemical or surgical treatments, due to their mainly antiapoptotic, anti-\ninflammatory and antioxidant properties, phytotherapeutic preparations and their natural compounds\ncan be applied to prevent or treat eye disease as follows: oral, topical or both. Thus, this\nstudy aims to comprehensively evaluate the pre-clinical and clinical studies of the phytotherapeutics\nand natural compounds used in the prevention and treatment of common serious and painful\neye diseases. Moreover, for the first time, nature-derived preparations\/supplements commonly used\nfor eye problems also included in this review to present applications of the extracts\/compounds in\nthe pharmaceutical field.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874467213666201221163210","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T04:29:36Z","timestamp":1608611376000},"page":"689-713","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phytotherapeutic and Natural Compound Applications for Age-Related, Inflammatory and Serious Eye Ailments"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-7552","authenticated-orcid":true,"given":"Methiye M.","family":"Karaku\u015f","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5216-7588","authenticated-orcid":true,"given":"Ufuk K.","family":"\u00c7al\u0131\u015fkan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","container-title":["Current Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189322\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T22:57:16Z","timestamp":1746572236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189322\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,12,16]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1874467213666201221163210","relation":{},"ISSN":["1874-4672"],"issn-type":[{"value":"1874-4672","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,16]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}