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Inflammation deputes a common feature of various chronic diseases and the direct\ninvolvement in the insurgence and development of these conditions. Macrophages participate in an autoregulatory\nloop characterizing the inflammatory process, as they produce a wide range of biologically\nactive mediators that exert either deleterious or beneficial effects during the inflammation. Therefore,\nbalancing the favorable ratios of M1\/M2 macrophages can help ameliorate the inflammatory landscape\nof pathologic conditions. Curcumin is a component of turmeric with many pharmacological properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Recent results from both in-vivo and in-vitro studies have indicated that curcumin can affect\npolarization and\/or functions of macrophage subsets in the context of inflammation-related diseases.\nThere is no comprehensive review of the impact of curcumin on cytokines involved in macrophage polarization\nin the context of inflammatory diseases. The present review will cover some efforts to explore\nthe underlying molecular mechanisms by which curcumin modulates the macrophage polarization in distant\npathological inflammatory conditions, such as cancer, autoimmunity, renal inflammation, stroke, atherosclerosis,\nand macrophage-driven pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>The accumulation of the findings from in vitro and in vivo experimental studies suggests that\ncurcumin beneficially influences M1 and M2 macrophages in a variety of inflammatory diseases with\nunfavorable macrophage activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Curcumin not only enhances anti-tumor immunity (via shifting M polarization towards M1\nphenotype and\/or up-regulation of M1 markers expression) but ameliorates inflammatory diseases, including\nautoimmune diseases (experimental autoimmune myocarditis and Behcet's disease), nephropathy,\nchronic serum sickness, stroke, and atherosclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1874467215666220324114624","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:13:02Z","timestamp":1648167182000},"page":"2-14","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Immunomodulatory Therapeutic Effects of Curcumin on M1\/M2 Macrophage\nPolarization in Inflammatory Diseases"],"prefix":"10.1016","volume":"16","author":[{"given":"Sara","family":"Azhdari","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, School of Medicine, Bam University\nof Medical Sciences, Bam, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Shapouri","family":"Moghaddam","sequence":"first","affiliation":[{"name":"Department of Immunology, Bu\u2010Ali Research Institute, Faculty of Medicine, Mashhad\nUniversity of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-3557","authenticated-orcid":true,"given":"Elham","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Woman Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Department of Medical Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad,\nIran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Ghaneifar","sequence":"additional","affiliation":[{"name":"Department\nof Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Department of Anatomical\nSciences, Maragheh University of Medical Sciences, Maragheh, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Goleij","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Biology,\nSana Institute of Higher Education, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/ijms22020950","volume":"22","author":"DiPietro L.A.","year":"2021","unstructured":"DiPietro L.A.; Wilgus T.A.; Koh T.J.; Macrophages in healing wounds: Paradoxes and paradigms. 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