{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:49Z","timestamp":1753889989896,"version":"3.41.2"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMP"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>Following heart surgery, postoperative atrial fibrillation (AF) is the most prevalent kind of secondary AF and the most frequent adverse event.\nPostoperative AF is related to a number of unfavorable cardiac outcomes, such as heart failure, stroke, and death. However, the pharmacological\ntreatment for postoperative AF is only relatively efficient and is frequently linked to detrimental complications, including symptomatic bradycardia\nwith atrioventricular block due to rate control drugs and elevated hemorrhage hazard attributable to the administration of anticoagulants. Ablation\nprocedures also result in the irreversible damage of cardiac anatomic structures, which may have long-term negative implications on heart\nperformance. As a result, there is an unmet demand for treatments that can minimize the incidence of postoperative AF in an effective and safe\nmanner. Botulinum toxin is an established neurotoxin that has progressively gained use in every medical science domain. It hinders the propagation\nof impulses across nerve fibers without causing immediate damage to the cardiac tissue. The transient feature of botulinum toxin action and the\neventual restoration of the autonomic nervous system transmission are undeniably advantageous and may render botulinum toxin a potential and\nfeasible treatment approach for postoperative AF.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874467217666230620114931","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:30:41Z","timestamp":1694032241000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiarrhythmic Potential of Epicardial Botulinum Toxin Injection for\nSuppression of Postoperative Atrial Fibrillation"],"prefix":"10.1016","volume":"17","author":[{"given":"Michael","family":"Spartalis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sotiria Thoracic Diseases General Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Spartalis","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u2018N. S. Christeas\u2019, National and Kapodistrian University of Athens, Medical School,\nAthens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Iliopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u2018N. S. Christeas\u2019, National and Kapodistrian University of Athens, Medical School,\nAthens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Siasos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sotiria Thoracic Diseases General Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.toxicon.2017.08.014","volume":"147","author":"Cocco A.","year":"2018","unstructured":"Cocco A.; Albanese A.; Recent developments in clinical trials of botulinum neurotoxins. 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