{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:27:08Z","timestamp":1772807228017,"version":"3.50.1"},"reference-count":15,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRP"],"published-print":{"date-parts":[[2021,3,31]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal\nrecessive disorder. Neuroimaging findings are commonly considered rather non-specific. To\ndate, no neuroreceptorial brain imaging with <jats:sup>123<\/jats:sup>I-FP-CIT(DaTScan) is known in subjects with SSADH\ndeficiency.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A 30-year-old man gained our attention to rule out any potential nigrostriatal dopaminergic\npresynaptic pathway alterations in a clinical context of a \u03b3-hydroxybutyric aciduria. He showed impossibility\nto the autonomous gait, head and trunk retropulsion, lower limbs strength deficit, verbal and\nupper limbs motor stereotypies and irregular eye tracking.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>His brain MRI depicted basal ganglia signal abnormalities. Brain SPECT with DaTSCan images\nshowed a global significant reduction of radiotracer uptake.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>The findings obtained by means of the <jats:sup>123<\/jats:sup>I-DaTScan brain SPECT may give rise to new\nconcerns on pathophysiological aspects of the SSADH deficiency disorder that has never been investigated\nbefore, such as the nigrostriatal dopaminergic system\u2019s functionality, encouraging further investigation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874471013666200325101302","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T14:35:51Z","timestamp":1585146951000},"page":"78-83","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["123I-FP-CIT Brain SPECT Findings in Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency"],"prefix":"10.2174","volume":"14","author":[{"given":"Viviana","family":"Frantellizzi","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Pontico","sequence":"additional","affiliation":[{"name":"PhD. 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