{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:22:29Z","timestamp":1747207349787,"version":"3.40.5"},"reference-count":40,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRP"],"published-print":{"date-parts":[[2021,6,4]]},"abstract":"<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Thyroid carcinoma represents a complex pathology that can still be considered a medical\nchallenge, despite having a better prognosis and life expectancy than most other neoplasms; also\nthe scenario of multiple malignancies involving thyroid cancer is nowadays a common reality.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>We reviewed the literature regarding the aggressive presentation of\nsynchronous thyroid and breast cancer. In the current paper, we report the case of a 59 years-old\nwoman, diagnosed with invasive ductal breast carcinoma and papillary thyroid carcinoma, presenting\na natural history of both aggressive synchronous tumors. At the moment of hospitalization, the\ndiagnosis was breast carcinoma with multiple secondary lesions, suggestive of lung and bone metastases,\nand nodular goiter.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Searching the literature in PUBMED with the terms \u201cthyroid\ncarcinoma and synchronous breast carcinoma, we found 86 studies; introducing the term \u201caggressive,\u201d\nthe result included 4 studies, among which, none showed to be relevant to the terms aggressive\nand synchronous. A similar search was done in SCOPUS finding 92 documents and after introducing\nthe term aggressive, the number of papers was 8, none including the literature on synchronous\naggressive metastatic thyroid and breast carcinoma. A majority of imaging diagnostic tools\nwere used in this particular medical case in order to ensure the best potential outcome. The final diagnosis\nwas papillary thyroid carcinoma with lung and unusual multiple bone metastases and\nsynchronous invasive ductal breast carcinoma with subcutaneous metastases.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The case illustrates the challenges in the correct assessment of oncologic patients, despite the advances in\nmedical imaging and technologies and underlines the essential role of nuclear medicine procedures\nin the diagnostic and therapy protocols.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874471013666200928105151","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T04:59:17Z","timestamp":1601355557000},"page":"85-91","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenges in the Correct Assessment of a Case of Aggressive Thyroid Carcinoma with Synchronous Breast Cancer: A Case Report and Review of the Literature of Essential Role of Radiopharmaceuticals"],"prefix":"10.2174","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-1851","authenticated-orcid":true,"given":"Andra","family":"Piciu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-4307","authenticated-orcid":true,"given":"Alexandru","family":"Mester","sequence":"additional","affiliation":[{"name":"Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Tumors and Nuclear Medicine Institute of Oncology Ion Chiricuta 400015 Cluj-- Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-7449","authenticated-orcid":true,"given":"Doina","family":"Piciu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Tumors and Nuclear Medicine Institute of Oncology Ion Chiricuta 400015 Cluj-- Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"1","author":"Institute N.N.C.","year":"2020","unstructured":"Institute N.N.C.; Cancer Facts","journal-title":"CA Cancer J Clin"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1089\/thy.2014.0594","volume":"25","author":"Brito J.P.","year":"2015","unstructured":"Brito J.P.; Al Nofal A.; Montori V.M.; Hay I.D.; Morris J.C.; The Impact of Subclinical Disease and Mechanism of Detection on the Rise in Thyroid Cancer Incidence: A Population-Based Study in Olmsted County, Minnesota During 1935 Through 2012. 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