{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:45:09Z","timestamp":1777301109290,"version":"3.51.4"},"reference-count":25,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRP"],"published-print":{"date-parts":[[2021,3,31]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Early diagnosis of Parkinson's disease (PD) is of primary importance. The\ndelayed (3-4 h after injection) Iodine-123-Metaiodobenzylguanidine (123I-mIBG) scintigraphy has\nbeen proven to be effective in early differential diagnosis for Lewy body disease. But early imaging\n(15-30 min after injection) has only been marginally studied for its possible diagnostic role. In\nthis prospective study, a threshold for the early Heart-to-Mediastinum (H\/M) count ratio has been\ninvestigated, obtaining a diagnostic accuracy analogous to conventional, delayed imaging.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> One hundred and eight patients with suspected Parkinson's disease (PD) were acquired\nafter 15 and 240 minutes from the injection of 150-185 MBq of 123I-mIBG. The early and late\nH\/M (He\/Me and Hl\/Ml) were evaluated by drawing Region-of-Interests on the heart and the upper\nhalf of the mediastinum. Optimal threshold (Youden index) and overall predictive performance\nwere determined by receiver operating characteristic curve, classifying tentatively patients having\nan Hl\/Ml lower than 1.6 as suffering from PD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>He\/Me was not significantly different from Hl\/Ml (p-value=0.835). The Area-under-curve\nwas 0.935 (95%CI: 0.845-1.000). The He\/Me optimal threshold was 1.66, with sensitivity, specificity,\nand diagnostic accuracy of 95.5%, 85.7 and 90.7% respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>The He\/Me Ratio is almost as accurate as the widely used delayed 123I-mIBG imaging,\nreducing the burden of delayed imaging but preserving the diagnostic accuracy of the method.\nMoreover the differential diagnosis in Parkinson's disease can be made in just 25 minutes against\nthe 4 hours currently needed, lowering costs of the healthcare system and improving patients compliance.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874471013999200727211633","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T09:01:42Z","timestamp":1595926902000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic Value of the Early Heart-to-Mediastinum Count Ratio in Cardiac 123I-mIBG Imaging for Parkinson's Disease"],"prefix":"10.2174","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-4236","authenticated-orcid":true,"given":"Viviana","family":"Frantellizzi","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Sapienza, \u201cSapienza\u201d University of Rome, viale Regina Elena,324, 00161Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-1706","authenticated-orcid":true,"given":"Valentina","family":"Lavelli","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-8551","authenticated-orcid":true,"given":"Cristina","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Sardaro","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine, Section of Radiology and Radiation Oncology, University of Bari \u201cAldo Moro\u201d, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Farcomeni","sequence":"additional","affiliation":[{"name":"Department of Economic and Finance, \u201cTor Vergata\u201d University of Rome, via Columbia, 2, 00133Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Pacilio","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Azienda Ospedaliera Universitaria Policlinico Umberto I, viale del Policlinico 155, 00161Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Borrazzo","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Azienda Ospedaliera Universitaria Policlinico Umberto I, viale del Policlinico 155, 00161Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Pani","sequence":"additional","affiliation":[{"name":"Department of Sciences and Medico-Surgical Biotechnologies, \u201cSapienza\u201d University of Rome, viale Regina Elena,324, 00161Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rubini","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe De","family":"Vincentis","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza, \u201cSapienza\u201d University of Rome, viale Regina Elena,324, 00161Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1001\/archneur.55.7.969","volume":"55","author":"Litvan I.","year":"1998","unstructured":"Litvan I.; MacIntyre A.; Goetz C.G.; Wenning G.K.; Jellinger K.; Verny M.; Bartko J.J.; Jankovic J.; McKee A.; Brandel J.P.; Chaudhuri K.R.; Lai E.C.; D\u2019Olhaberriague L.; Pearce R.K.B.; Agid Y.; Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. 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