{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:38:36Z","timestamp":1791236316211,"version":"4.1.0"},"reference-count":15,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n<jats:title>Aim:<\/jats:title>\n<jats:p>The present study aims to compare interleukin 6 concentration in synovial fluid in patients with known types of arthritis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Persistent synovitis without known markers, such as Rheumatoid Factor (RF), Anti-Citrullinated Protein Antibodies (ACPA), and genetic markers as HLA-B27, is not uncommon. It is valuable to determine the presence of chronic inflammation and put it in correlation with age-related changes, which are especially relevant for middle-aged patients with mono- or oligoarthritis, when the dilemma to start disease-modifying drugs for inflammatory disease often is present. Interleukin 6 (IL-6) plays a significant role in chronic inflammation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objectives:<\/jats:title>\n<jats:p>IL-6 concentration in synovial fluid reflects the presence and activity of joint inflamma-tion.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Synovial fluid was obtained from 101 patients with chronic synovitis. IL-6 concentration was determined by the immunochemical luminescence method.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The median IL-6 concentration in synovial fluid in patients with osteoarthritis (OA) was 138.0 pg\/ml (interquartile range (IQR) 43.4 to 296.0); in patients with rheumatoid arthritis was 2516.5 pg\/ml, (IQR 1136.0 to 25058.0); in reactive arthritis 2281.0 pg\/ml (IQR 1392.0 to 8652.0); psoriatic arthritis 1964.0 pg\/ml (IQR 754.0 to 7300.0); ankylosing spondylitis 2776.0 pg\/ml (IQR 514.7, 3944.0); in a group with negative RF, ACPA and HLA-B27 inflammatory arthritis 2163.0 pg\/ml (IQR 822.0 to 7875.0). There is statistically significant difference of IL-6 concentration com-paring OA and each inflammatory arthritis group, p&lt;0.0001.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>IL-6 detection in the synovial fluid is helpful in arthritis evaluation. The results show that an IL-6 level over 1000 pg\/ml suggests the diagnosis of inflammatory arthritis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874471015666220128113319","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T11:59:35Z","timestamp":1643371175000},"page":"230-233","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Interleukin 6 Concentration in Synovial Fluid of Patients with Inflammatory\nand Degenerative Arthritis"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2541-4296","authenticated-orcid":true,"given":"Anna","family":"Mihailova","sequence":"first","affiliation":[{"name":"Riga Stradins University, Faculty of Medicine, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295","volume":"6","author":"Tanaka T.","year":"2014","unstructured":"Tanaka T.; Narazaki M.; Kishimoto T.; IL-6 in inflammation, immunity, and disease. 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