{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:35:26Z","timestamp":1788910526788,"version":"build-2803163510"},"reference-count":20,"publisher":"Bentham Science Publishers Ltd.","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903144"],"award-info":[{"award-number":["81903144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRP"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Myelosuppression is common and threatening during tumor treatment.\nHowever, the effect of radiation on bone marrow activity, especially leukocyte count, has been\nunderestimated in cervical cancer. The aim of this study was to evaluate the severity of radiotherapy-\ninduced acute leukopenia and its relationship with intestinal toxicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The clinical data of 59 patients who underwent conventional radiation alone for cervical\ncancer were retrospectively analyzed. The patients had normal leukocyte count on admission, and\nthe blood cell count, gross tumor volume (GTV) dose, and intestinal toxicity were evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>During radiotherapy (RT), 47 patients (79.7%) developed into leukopenia, with 38.3%\nmild and 61.7% moderate. The mean time for leukopenia was 9 days. Compared with leukopenianegative\npatients, leukopenia-positive ones had lower baseline leukocyte count, while neutrophil\/\nlymphocyte (NLR) and monocyte\/lymphocyte (MLR) showed no significance. Logistic regression\nanalysis indicated that excluding the factors for age, body mass index (BMI), TNM stage,\nsurgery and GTV dose, baseline leukocyte count was an important independent predictor of leukopenia\n(OR=0.383). During RT, a significant reduction was found in leukocyte, neutrophil and\nlymphocyte count at week 2 while monocyte count after 2 weeks. Furthermore, NLR and MLR\nshowed a significant and sustained upward trend. About 54.2% of patients had gastrointestinal\nsymptoms. However, no significant relevance was noted between leukocyte count as well as\nNLR\/MLR and intestinal toxicity, indicating leukopenia may not be the main factor causing and\naggravating gastrointestinal reaction in cervical cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our results suggest the underrated high prevalence and severity of leukopenia in cervical\ncancer patients receiving RT, and those with low baseline leukocyte count are more likely for\nleukopenia, for whom early prevention of infection may be needed during RT.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874471015666221010141250","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T06:37:06Z","timestamp":1665556626000},"page":"50-56","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Undervalued Acute Leukopenia Induced By Radiotherapy In Cervical\nCancer"],"prefix":"10.2174","volume":"16","author":[{"given":"Ruishuang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of radiotherapy and chemotherapy, Ningbo First Hospital, Ningbo, People\u2019s Republic of China"},{"name":"Central\nlaboratory of Ningbo First Hospital, Ningbo First Hospital, Ningbo, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of radiotherapy and chemotherapy, Ningbo First Hospital, Ningbo, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of radiotherapy and chemotherapy, Ningbo First Hospital, Ningbo, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of radiotherapy and chemotherapy, Ningbo First Hospital, Ningbo, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenchao","family":"Guo","sequence":"additional","affiliation":[{"name":"Central\nlaboratory of Ningbo First Hospital, Ningbo First Hospital, Ningbo, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengrong","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of radiotherapy and chemotherapy, Ningbo First Hospital, Ningbo, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","volume":"393","author":"Cohen P.A.","year":"2019","unstructured":"Cohen P.A.; Jhingran A.; Oaknin A.; Denny L.; Cervical cancer. 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