{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:47:13Z","timestamp":1783831633979,"version":"3.55.0"},"reference-count":144,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAS"],"published-print":{"date-parts":[[2020,4,25]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Although telomerase has potential for age-related disease intervention, the\noverexpression of telomerase in about 90% of cancers, and in HIV virus reservoirs, cautions against\nse in anti-aging telomerase therapeutics. While multiple reviews document the canonical function\nof telomerase for maintenance of telomeres, as well as an increasing numbers of reviews that reveal\nnew non-canonical functions of telomerase, there was no systematic review that focuses on the array\nof associates of the subunit of Telomerase Reverse transcriptase protein (TERT) as pieces of\nthe puzzle to assemble a picture of the how specific TERT complexes uniquely impact aging and\nage-related diseases and more can be expected.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A structured search of bibliographic data on TERT complexes was undertaken using databases\nfrom the National Center for Biotechnology Information Pubmed with extensive access to\nbiomedical and genomic information in order to obtain a unique documented and cited overview of\nTERT complexes that may uniquely impact aging and age-related diseases.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The TERT associations include proper folding, intracellular TERT transport, metabolism,\nmitochondrial ROS (Reactive Oxygen Species) regulation, inflammation, cell division, cell death,\nand gene expression, in addition to the well-known telomere maintenance. While increase of cell\ncycle inhibitors promote aging, in cancer, the cell cycle check-point regulators are ambushed in favor\nof cell proliferation, while cytoplasmic TERT protects a cell cycle inhibitor in oxidative stress.\nThe oncogene cMyc regulates gene expression for overexpression of TERT, and reduction of cell\ncycle inhibitors-the perfect storm for cancer promotion. TERT binds with the oncogene RMRP\nRNA, and TERT-RMRP function can regulate levels of that oncogene RNA, and TERT in a TBN\ncomplex can regulate heterochromatin. Telomerase benefit and novel function in neurology and\ncardiology studies open new anti- aging hope. GV1001, a 16 amino acid peptide of TERT that associates\nwith Heat Shock Proteins (HSP\u2019s), bypasses the cell membrane with remarkable anti disease\npotential.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>TERT \u201cassociates\u201d are anti-cancer targets for downregulation, but upregulation in\nantiaging therapy. The overview revealed that unique TERT associations that impact all seven pillars\nof aging identified by the Trans-NIH Geroscience Initiative that influence aging and urge research\nfor appropriate targeted telomerase supplements\/ stimulation, and inclusion in National Institute\non Aging Intervention Testing Program. The preference for use of available \u201csmart drugs\u201d,\ntargeted to only cancer, not off-target anti- aging telomerase is implied by the multiplicity of TERT\nassociates functions.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874609812666190620124324","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T06:52:36Z","timestamp":1561963956000},"page":"11-21","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics"],"prefix":"10.2174","volume":"13","author":[{"given":"Joan","family":"Smith-Sonneborn","sequence":"first","affiliation":[{"name":"Department Zoology and Physiology, University of Wyoming, Laramie, Wyoming, WY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.ejca.2015.03.010","volume":"51","author":"Huang D.S.","year":"2015","unstructured":"Huang D.S.; Wang Z.; He X.J.; Diplas B.H.; Yang R.; Killela P.J.; Meng Q.; Ye Z.Y.; Wang W.; Jiang X.T.; Xu L.; He X.L.; Zhao Z.S.; Xu W.J.; Wang H.J.; Ma Y.Y.; Xia Y.J.; Li L.; Zhang R.X.; Jin T.; Zhao Z.K.; Xu J.; Yu S.; Wu F.; Liang J.; Wang S.; Jiao Y.; Yan H.; Tao H.Q.; Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation. 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