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These diseases include Alzheimer\u2019s disease\n(AD), Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD), Amyotrophic Lateral Sclerosis (ALS),\netc. Although these diseases have a common characteristic feature of progressive neuronal loss\nfrom various parts of the brain, they differ in the clinical symptoms and risk factors, leading to the\ndevelopment and progression of the diseases. AD is a neurological condition that leads to dementia\nand cognitive decline due to neuronal cell death in the brain, whereas PD is a movement disorder\naffecting neuro-motor function and develops due to the death of the dopaminergic neurons in the\nbrain, resulting in decreased dopamine levels. Currently, the only treatment available for these neurodegenerative\ndiseases involves reducing the rate of progression of neuronal loss. This necessitates\nthe development of efficient early biomarkers and effective therapies for these diseases. Long\nnon-coding RNAs (LncRNAs) belong to a large family of non-coding transcripts with a minimum\nlength of 200 nucleotides. They are implied to be involved in the development of the brain, a variety\nof diseases, and epigenetic, transcriptional, and posttranscriptional levels of gene regulation. Aberrant\nexpression of lncRNAs in the CNS is considered to play a major role in the development and\nprogression of AD and PD, two of the most leading causes of morbidity among elderly populations.\nIn this mini-review, we discuss the role of various long non-coding RNAs in neurodegenerative\ndiseases, such as Alzheimer\u2019s and Parkinson\u2019s disease, which can further be studied for the development\nof potential biomarkers and therapeutic targets for various neurodegenerative diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874609815666220126095847","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T04:59:52Z","timestamp":1643259592000},"page":"84-96","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of Long Non-coding RNAs in the Pathogenesis of Alzheimer\u2019s and\nParkinson\u2019s Diseases"],"prefix":"10.2174","volume":"15","author":[{"given":"Narmadhaa","family":"Sivagurunathan","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Molecular Pharmacology &amp; Toxicology Laboratory, School of Life Sciences, Central University\nof Tamil Nadu, Neelakudi Campus, Thiruvarur - 610005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aghil T.S.","family":"Ambatt","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Molecular Pharmacology &amp; Toxicology Laboratory, School of Life Sciences, Central University\nof Tamil Nadu, Neelakudi Campus, Thiruvarur - 610005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6637-369X","authenticated-orcid":true,"given":"Latchoumycandane","family":"Calivarathan","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Molecular Pharmacology &amp; Toxicology Laboratory, School of Life Sciences, Central University\nof Tamil Nadu, Neelakudi Campus, Thiruvarur - 610005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1289\/ehp.7567","volume":"113","author":"Brown R.C.","year":"2005","unstructured":"Brown R.C.; Lockwood A.H.; Sonawane B.R.; Neurodegenerative diseases: An overview of environmental risk factors. 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