{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:56:03Z","timestamp":1769180163509,"version":"3.49.0"},"reference-count":27,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K09020"],"award-info":[{"award-number":["JP17K09020"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MIRNA"],"published-print":{"date-parts":[[2019,2,17]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Neglected Tropical Diseases (NTDs) are a common health problem and require an\nefficient campaign to be eradicated from tropical countries. Almost a million people die of NTDs\nevery year in the world, and almost forty percent of the patients are under 20 years. Mass Drug Administration\n(MDA) is an effective tool for eradication of this health condition. However, a\nmonitoring system is required to evaluate treatment-response and early detection of the re-emerging\nNTD. The relevance of current tests depends on good quality of the specimen. Thus, new molecular\nmethods with high sensitivity and specificity are required. In this review, we focus on microRNAs\n(miRNAs) as biomarkers of NTDs through a narrative review on human research. We searched for\nreliable search engines using a systematical literature review algorithm and included studies that fit\nthe criterion. Five NTDs (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted\nhelminthiases, and trachoma) were set as our target diseases. Later on, the data were extracted and\nclassified as monitoring response and early detection. Four miRNAs were studied in filariasis as a\nmonitoring response. There were 12 miRNAs related to onchocerciasis infection, and 6 miRNAs\nwith schistosomiasis infection. Six miRNAs showed a link to soil-transmitted helminths. Only 3\nmiRNAs correlated with trachoma infection. In conclusion, circulating miR is a less invasive and\npromising approach to evaluate NTDs. Further field study may translate those candidate miRs to\nclinical application of the prevention and control of NTDs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2211536608666190620104308","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T08:18:45Z","timestamp":1561018725000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neglected Tropical Diseases: The Potential Application of microRNAs for Monitoring NTDs in the Real World"],"prefix":"10.2174","volume":"9","author":[{"given":"Supat","family":"Chamnanchanunt","sequence":"first","affiliation":[{"name":"Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-9838","authenticated-orcid":true,"given":"Saovaros","family":"Svasti","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suthat","family":"Fucharoen","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukuru","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Medical Technology and Sciences, International University of Health and Welfare, Ohkawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005355","volume":"11","author":"Hotez P.","year":"2017","unstructured":"Hotez P.; Aksoy S.; PLOS neglected tropical diseases: ten years of progress in neglected tropical disease control and elimination \u2026 More or less. 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