{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:39:34Z","timestamp":1773689974301,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MIRNA"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>The primate-specific microRNA gene cluster on chromosome 19 (C19MC) is composed\nof 56 mature microRNAs (miRNAs), which are divided into three subgroups according to the sequence\nsimilarity. This cluster is principally expressed in the placenta but not in other tissues.\nC19MC is involved in the regulation of proliferation, migration, and invasion of trophoblastic\ncells, which are important for the development of the placenta. There is a growing number of\nstudies that have found an altered expression of some miRNAs of the C19MC cluster in cancer,\nsuggesting that these could play an important role in the development of this disease. Therefore, in\nthis work, we provided an overview of the C19MC cluster's role in cancer through a systematic review\nof published articles. In particular, we focused on miRNAs of subgroup 3. These studies\nsuggest that miRNAs such as miR-512-3p, miR-512-5p, miR-516a-5p, miR-516b-5p, and\nmiR-498-5p could play a pivotal role in the development of therapies for cancer. Future studies are\nnecessary to elucidate the molecular processes and pathways regulated by subgroup 3 miRNAs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2211536610666211022144655","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T16:43:40Z","timestamp":1635093820000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Overview of C19MC Cluster Subgroup 3 and Cancer"],"prefix":"10.2174","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-5542","authenticated-orcid":true,"given":"\u00c1ngela Y. Garc\u00eda","family":"Fonseca","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C.,Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneth Gonzalez","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C.,Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-4867","authenticated-orcid":true,"given":"Andr\u00e9s Felipe","family":"Aristiz\u00e1bal-Pach\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogot\u00e1 D.C.,Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["MicroRNA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/197362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.eurekaselect.com\/197362\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eurekaselect.com\/article\/download\/197362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T11:29:59Z","timestamp":1640950199000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/197362\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/2211536610666211022144655","relation":{},"ISSN":["2211-5366"],"issn-type":[{"value":"2211-5366","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}