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A large number of microRNAs\n(miRNAs) regulated by different strains of T. gondii in diverse types of host cells\/tissues\/organs\nhave been reported across multiple studies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>We aimed to decipher the complexity of T. gondii regulated spectrum of miRNAs to derive\na set of core miRNAs central to different strains of T. gondii infection in diverse human cell\nlines.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We first assembled miRNAs hat are regulated by T. gondii altered across the various assortment\nof infections and time points of T. gondii infection in multiple cell types. For these assembled\ndatasets, we employed specific criteria to filter the core miRNAs regulated by T. gondii.\nSubsequently, accounting for the spectrum of miRNA-mRNA target combinations, we applied a\nnovel confidence criterion to extract their core experimentally-validated mRNA targets in human\ncell systems.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>This analysis resulted in the extraction of 74 core differentially regulated miRNAs and\ntheir 319 high-confidence mRNA targets. Based on these core miRNA-mRNA pairs, we derived the\ncentral biological processes perturbed by T. gondii in diverse human cell systems. Further, our analysis\nalso resulted in the identification of novel autocrine\/paracrine signalling factors that could be\nassociated with host response modulated by T. gondii.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The current analysis derived a set of core miRNAs, their targets, and associated biological\nprocesses fine-tuned by T. gondii for its survival within the invaded cells.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2211536611666220428130250","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T21:29:13Z","timestamp":1651267753000},"page":"163-174","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Core Human MicroRNAs Regulated by <i>Toxoplasma gondii<\/i>"],"prefix":"10.2174","volume":"11","author":[{"given":"Neelam","family":"Antil","sequence":"first","affiliation":[{"name":"Centre for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University),\nMangalore 575018, India"},{"name":"Institute of Bioinformatics, International Technology Park, Bangalore 560066, India"},{"name":"Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Arefian","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University),\nMangalore 575018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrudula Kinarulla","family":"Kandiyil","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University),\nMangalore 575018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriti","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University),\nMangalore 575018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thottethodi Subrahmanya Keshava","family":"Prasad","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University),\nMangalore 575018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Raju","sequence":"additional","affiliation":[{"name":"Centre for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University),\nMangalore 575018, India"},{"name":"Centre for Integrative Omics\nData Science, Yenepoya (Deemed to be University), Mangalore 575018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3109\/00365548.2012.693197","volume":"44","author":"Saadatnia G.","year":"2012","unstructured":"Saadatnia G.; Golkar M.; A review on human toxoplasmosis. 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