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Aberrant regulation in any of these modes may contribute to orofacial defects. Noncoding RNAs (ncRNAs), such as long ncRNAs (lncRNAs) and circular RNAs (circRNAs), have been shown to alter miRNA expression, and are thus emerging as novel contributors to gene regulation. Some of these appear to function as \u2018miRNA sponges\u2019, there-by diminishing the availability of these miRNAs to inhibit the expression of target genes. Such ncRNAs are also termed competitive endogenous RNAs (ceRNAs). Here, we examine emerging data that shed light on how lncRNAs and circRNAs may alter miRNA regulation, thus affecting orofacial development and potentially contributing to orofacial clefting.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2211536612666230524153442","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T09:19:09Z","timestamp":1685006349000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of lncRNAs and circRNAs in Orofacial Clefts"],"prefix":"10.2174","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-1070","authenticated-orcid":true,"given":"Ratnam S.","family":"Seelan","sequence":"first","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, University of Louisville School of Dentistry, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6456-8103","authenticated-orcid":true,"given":"Robert M.","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, University of Louisville School of Dentistry, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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