{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:30:25Z","timestamp":1788550225982,"version":"build-2803163510"},"reference-count":36,"publisher":"Bentham Science Publishers Ltd.","issue":"4","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PNT"],"published-print":{"date-parts":[[2019,9,24]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Development of polymeric micelles for the management of allergic\nconjunctivitis to overcome the limitations of topical installation, such as poor patient\ncompliance, poor stromal permeability, and significant adverse effects, increase precorneal\nresidence time and efficacy, and also control the release of drug at the target site.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The investigation was aimed at developing a polymeric micellar system of\nAzelastine HCl for Ocular Delivery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Drug loaded micelles of tri-block copolymers Pf 127 were prepared by Thin\nFilm hydration method. The polymeric micelles formulations (F1 to F9) were assessed for\nentrapment efficiency, micelle size, in vitro permeation, ex vivo transcorneal permeation,\nin vivo Ocular Irritation, and Histology.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Optimized micelles formulation (F3), with the lowest micelle size of 92 nm, least\npolydispersity value of 0.135, highest entrapment efficiency of 95.30 \u00b1 0.17%, and a cumulative\ndrug permeation of 84.12 \u00b1 1.26% in 8h, was selected to develop pH-sensitive\nmicelles loaded carbopol in situ gel. The optimized in situ gel (G4) proved to be superior\nin its ex vivo transcorneal permeation when compared with Market Preparation and pure\ndrug suspension, exhibiting 43.35 \u00b1 1.48% Permeation with zero-order kinetics (r2 =\n0.9944) across goat cornea. Transmission Electron microscopy revealed spherical polymeric\nmicelles trapped in the gel matrix. A series of experiments showed hydration capability,\nnon-irritancy, and histologically safe gel formulation that had appropriate handling characteristics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>A controlled release pH-sensitive ocular formulation capable of carrying the\ndrug to the anterior section of the eye via topical delivery was successfully developed for\nthe treatment of allergic conjunctivitis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2211738507666190726162000","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T05:49:06Z","timestamp":1564638546000},"page":"314-327","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Novel Approach of Drug Localization through Development of Polymeric Micellar System Containing Azelastine HCl for Ocular Delivery"],"prefix":"10.2174","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-5214","authenticated-orcid":true,"given":"Sheetal","family":"Devi","sequence":"first","affiliation":[{"name":"M.M. 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