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In addition, the specific absorption spectrum of indomethacin\nshows the effect of absorbing short-wavelength blue-violet light.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>We prepared an indomethacin-loaded hydrogel as a potential intraocular lens (IOLs)\nmaterial to prevent endophthalmitis, PCO and filter harmful blue light.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> Indomethacin prodrugs (HEMA-IND) (HI) were prepared by esterification of indomethacin\nand 2-hydroxyethyl methacrylate (HEMA), and poly (HEMA-co-MAA-co-MMA-co-\nHI) (HAMI) hydrogels were prepared by free-radical polymerization of 2-hydroxyethyl methacrylate\n(HEMA), methyl methacrylate (MMA), methacrylic acid (MAA) and HI. The physical\nand chemical properties of obtained hydrogel were detected, including optical, morphology,\nthermomechanical and surface properties, equilibrium water content, drug release behaviors and\ncytotoxicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>HAMI hydrogels can filter harmful short-wavelength blue light and show other necessary\nproperties like visible light transparency, glass transition temperatures, mechanical\nstrength, and biocompatibility for making intraocular lenses. Meanwhile, MAA increases the\nhydrophilicity of the hydrogels, resulting in a lower water contact angle and controllable drug\nrelease from the hydrogels.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In summary, HAMI hydrogels show a great potential as IOL biomaterials that can\nmaintain the sustained release of indomethacin and filter harmful blue light after cataract surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Lay Summary:<\/jats:title>\n<jats:p>People with cataract surgery can be at high risk of postoperative complications,\nsuch as PCO and postoperative endophthalmitis. Moreover, early IOLs allowed all ultraviolet\n(UV) and visible light to pass through retina without restriction, thus to damage the retina and\nthe retinal pigment epithelium, which may lead to retinopathy and age-related macular degeneration\n(AMD). Herein, we sought to design and prepare a kind of IOLs loaded with indomethacin\nto mitigate those postoperative complications and filter harmful blue light to improve the\ntreatment prognosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2211738508666200313144112","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T13:45:41Z","timestamp":1584107141000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Drug-loaded and Blue-ray Filtered Hydrogel as a Potential Intraocular Lens for Cataract Treatment"],"prefix":"10.2174","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-5296","authenticated-orcid":true,"given":"Yang","family":"Xiang","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9960-8889","authenticated-orcid":true,"given":"Mengwei","family":"Zou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-3256","authenticated-orcid":true,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7615-6800","authenticated-orcid":true,"given":"Rongrong","family":"Jin","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8647-1206","authenticated-orcid":true,"given":"Yu","family":"Nie","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.ajo.2007.02.015","volume":"143","author":"Riaz Y.","year":"2007","unstructured":"Riaz Y.; Mehta J.S.; Wormald R.; Surgical interventions for age-related cataract. 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