{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:25:07Z","timestamp":1774437907165,"version":"3.50.1"},"reference-count":34,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDRR"],"published-print":{"date-parts":[[2021,1,11]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Postpartum Hemorrhage (PPH) is one of the primary causes of maternal\nmortality and morbidity during the third stage of labor. Oxytocin is the gold standard uterotonic\nagent for the prevention of PPH.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>We aimed to compare the efficacy of oxytocin administered Intramuscularly (IM) or\nIntravenously (IV) for the preventive management of PPH.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We searched six databases for relevant clinical trials evaluating the administration of oxytocin\nfor the prevention against PPH through July 2019. Data on blood loss, PPH (\u2265500 ml), severe\nPPH (\u22651000 ml), blood transfusion, the change in hemoglobin, the use of additional uterotonics, and\nthe incidence of retained placenta were extracted and pooled in a meta-analysis model using\nRevMan version 5.3.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Seven studies with a total of 6996 participants were included. IM oxytocin group was\nassociated with higher incidence rates of PPH (\u2265500 ml) (RR=1.35; p=0.003), severe PPH (\u22651000\nml) (RR=1.58; p=0.04), and blood transfusion (RR=2.43; p=0.005). In terms of blood loss, the IV\nroute was superior to the IM route (SMD= 0.15; p=0.00001). However, we observed no statistically\nsignificant difference between the two routes regarding the change in Hb (SMD=-0.02; p=0.72) and\nthe use of additional uterotonics (RR=0.96, p= 0.94).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>IV oxytocin infusion is maybe superior to IM injection for the management of PPH.\nFurther studies with larger sample sizes are still needed to support these findings.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2589977512666200628013647","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T06:18:28Z","timestamp":1593497908000},"page":"150-157","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intravenous Oxytocin versus Intramuscular Oxytocin for the Management of Postpartum Hemorrhage: A Systematic Review and Meta-Analysis"],"prefix":"10.2174","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5284-2929","authenticated-orcid":true,"given":"Mahmoud Ahmed","family":"Ebada","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6301-0191","authenticated-orcid":true,"given":"Abdelmagid M.","family":"Elmatboly","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Azhar University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-3571","authenticated-orcid":true,"given":"Galal","family":"Baligh","sequence":"additional","affiliation":[{"name":"Department of Gynecology & Obstetrics, Zagazig General Hospital, Zagazig, El-Sharkia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/GRF.0b013e3181ce0965","volume":"53","author":"Rajan P.V.","year":"2010","unstructured":"Rajan P.V.; Wing D.A.; Postpartum hemorrhage: evidence-based medical interventions for prevention and treatment. 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