{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:58:02Z","timestamp":1790017082476,"version":"4.0.1"},"reference-count":35,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDRR"],"published-print":{"date-parts":[[2021,4,12]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>SeDeM (Sediment Delivery Model) expert system is a preformulation tool\nemployed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters\nderived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15\nparameters derived diagram that can be used as a research tool for reducing the product development\ntime. The best possible excipients for a specified pharmaceutical active ingredient could be\nscreened for direct compression suitability.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>SeDeM expert system has been successfully used and implemented for characterizing\ngalenic properties of pharmaceutical excipients, direct compression suitability of excipients, development\nof ODT formulations, development of sustained-release formulations, and development of\ntablets of taste-masked drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In the present review paper, the development and applications of SeDeM and SeDeMODT\nsystems have been discussed in detail.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/2589977512666200928113716","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T04:59:17Z","timestamp":1601355557000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["SeDeM Expert System, an Innovative Tool for Developing Directly Compressible Tablets: A Review"],"prefix":"10.2174","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1860-4246","authenticated-orcid":true,"given":"Inderbir","family":"Singh","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-4759","authenticated-orcid":true,"given":"Ajay Kumar","family":"Thakur","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6960-3403","authenticated-orcid":true,"given":"Rajni","family":"Bala","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-0272","authenticated-orcid":true,"given":"Reecha","family":"Madan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S1461-5347(99)00237-0","volume":"3","author":"Jivraj I.","year":"2000","unstructured":"Jivraj I.; Martini L.G.; Thomson C.M.; An overview of the different excipients useful for the direct compression of tablets. 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