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Eye\ndrops lead the pharmaceutical forms due to ease of application. Despite the poor bioavailability of\ndrugs administered topically, especially related to the dilution and excretion by tear fluid, the absence\nof controlled drug delivery, and the poor compliance within pediatric and senior populations,\neye drops and ointments are still the first choices in eye-related disorders management. Only a few\nstudies have explored the eyelid skin as a site for drug application and transdermal delivery as an\nalternative route of administration of ophthalmic drugs. Such works have validated the delivery of\ndrugs into the ocular tissues through the eyelid barrier. The eyelid represents a differentiated skin\nbarrier concerning the thickness, the structure of the &lt;i&gt;stratum corneum&lt;\/i&gt;, the vasculature, and the\namount of lipids. This work intends to question why the eyelid, being an accessible, non-invasive,\ncomfortable route of administration is not considered a feasible route for ophthalmic drugs. The eyelid\nstructure is presented, and the anatomical and physiological distinctive characteristics are presented.\nThe work also presents the research work on topical drug application to the eyelid skin that\nhas been published so far.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0113895575358373241220043138","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T10:04:01Z","timestamp":1736935441000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Topical Application onto the Eyelid Skin: Is it a Feasible Delivery Route of Ophthalmic Drugs?"],"prefix":"10.2174","volume":"25","author":[{"given":"Larysa","family":"Grygor\u2019yeva","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama\nPinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6028-4717","authenticated-orcid":true,"given":"Manuela Colla","family":"Carvalheiro","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama\nPinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-1790","authenticated-orcid":true,"given":"Sandra","family":"Simoes","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama\nPinto, 1649-003 Lisboa, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3390\/pharmaceutics14010134","volume":"14","author":"L\u00f6scher M.","year":"2022","unstructured":"L\u00f6scher M.; Seiz C.; Hurst J.; Schnichels S.; Topical drug delivery to the posterior segment of the eye. 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