{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T08:40:42Z","timestamp":1777279242822,"version":"3.51.4"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAR"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The locus coeruleus is the primary site of norepinephrine (NE) synthesis\nin the brain. Its dysfunction has been implicated in the pathogenesis of Alzheimer\u2019s disease. Vascular\nrisk factors, thyroid dysfunction, and vitamin deficiencies have also been associated with an\nincreased risk of dementia. This study aimed to evaluate the relationship between the catecholaminergic\nsystem-by measuring cerebrospinal fluid (CSF) levels of L-3,4-dihydroxyphenylalanine\n(L-DOPA), dopamine (DA), and NE-and vascular risk factors, thyroid dysfunction, and vitamin\ndeficiencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a cross-sectional observational study in which CSF levels of L-DOPA,\nDA and NE were measured in 117 participants. Data on Blood Pressure (BP), heart rate, glycaemic\nand lipid profiles, smoking history, thyroid function and vitamin B12 and folic acid levels\nwere collected for each participant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found significant correlations between NE and CSF glucose levels (r = 0.308, p =\n0.003) in participants without diabetes mellitus, between L-DOPA and orthostatic variation of diastolic\nBP (r = -0.288, p = 0.014) and high-density lipoprotein (r = 0.404, p = 0.001) and between\nNE and triglycerides (r = 0.271, p = 0.030) and folic acid (r = 0.298, p = 0.009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This is the first study to demonstrate correlations between CSF NE levels and CSF\nglucose, probably due to the effect of NE on astrocytes, and between CSF NE levels and folic acid,\npossibly related to its role in catecholamine synthesis. CSF L-DOPA levels were correlated\nwith cardiovascular risk factors such as the orthostatic regulation of diastolic BP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings may contribute to a better understanding of the pathophysiology of\nneurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115672050411466251014111557","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T09:13:38Z","timestamp":1767604418000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relation between Cerebrospinal Fluid Catecholamines and Vascular Risk Factors, Thyroid Function and Vitamins in Healthy Individuals and Patients with Neurodegenerative Diseases"],"prefix":"10.2174","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-5416","authenticated-orcid":true,"given":"Isabel Portela","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Neurology, Hospital Trofa Sa\u00fade Gaia, Vila Nova de Gaia, Portugal"}]},{"given":"Paula","family":"Serrao","sequence":"additional","affiliation":[{"name":"Pharmacology and TherapeuticsUnit, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Lucinda","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Department of Neurology,ULS S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"CSF Laboratory of the Department of Neurology, ULS S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Maria Jos\u00e9","family":"Sa","sequence":"additional","affiliation":[{"name":"CSF Laboratory of the Department of Neurology, ULS S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"FP-I3ID, Fernando Pessoa Institute for Research, Innovation and Development; FCS-UFP, Faculty of Health Sciences;RISE-UFP, Health Research Network, Fernando Pessoa University, Porto, Portugal"}]},{"given":"Maria Augusta","family":"Vieira-Coelho","sequence":"additional","affiliation":[{"name":"Pharmacology and TherapeuticsUnit, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Psychiatry,USL S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Joana","family":"Guimaraes","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Neurology,ULS S\u00e3o Jo\u00e3o, Porto, Portugal"}]}],"member":"965","container-title":["Current Alzheimer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672050411466251014111557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/249002\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672050411466251014111557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:47:08Z","timestamp":1777276028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/249002\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115672050411466251014111557","relation":{},"ISSN":["1567-2050"],"issn-type":[{"value":"1567-2050","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}