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They can interfere\nwith appetite, pain, and sleep or develop mood changes in the individual. Cannabidiol (CBD)\nis a well-known cannabinoid with potential benefits, including reducing epilepsy seizures, alleviating\nanxiety and obsessive-compulsive disorder (OCD) symptoms, aiding in Tourette Syndrome (a\nneurodevelopmental disorder), depression, sleep disorders, and promising in the treatment of cancer,\npain relief, and heart health. Although generally safe, CBD can have side effects, including\ndrug metabolism interference, fertility, and liver function. In addition, it can be administered by\noral, sublingual, transdermal, or inhalation via each one with different bioavailability. The application\nof nanotechnology, specifically through colloidal carrier systems, holds promising potential\nfor maximizing CBD's efficacy and pharmacological profile. There are reported CBD extraction\nmethods using ethanol, carbon dioxide, deionised water, and non-polar oils like olive or coconut\noil. Green extraction methods have gained popularity due to their higher yields, shorter extraction\ntime, and reduced costs. A specific dose with the desired effects is challenging due to individual\nfactors, with most studies suggesting a range between less than 1 and 50 mg\/kg\/d. This review\naims to explore the principles of CBD-based products development, focusing on extraction methods\nand purification processes of this cannabinoid for tinctures, topicals, and other pharmaceutical\nforms, as well as further research to attain the objectives.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115701638305553240529103622","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T09:58:26Z","timestamp":1717754306000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Understanding the Potential of CBD for Health Benefits: An Overview"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4552-2360","authenticated-orcid":true,"given":"Ivan","family":"Santos","sequence":"first","affiliation":[{"name":"REQUIMTE\/ LAQV, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Porto,\n4050-313, Portugal"},{"name":"Mesosystem Investiga\u00e7\u00e3o &amp; Investimentos by Spinpark, Barco, Guimar\u00e3es, 4805-017, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-6596","authenticated-orcid":true,"given":"Maria Beatriz Prior Pinto","family":"Oliveira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/ LAQV, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Porto,\n4050-313, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5420-3439","authenticated-orcid":true,"given":"Ana","family":"Casas","sequence":"additional","affiliation":[{"name":"Mesosystem Investiga\u00e7\u00e3o &amp; Investimentos by Spinpark, Barco, Guimar\u00e3es, 4805-017, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-7231","authenticated-orcid":true,"given":"Javier Fidalgo","family":"Lopez","sequence":"additional","affiliation":[{"name":"Mesosystem Investiga\u00e7\u00e3o &amp; Investimentos by Spinpark, Barco, Guimar\u00e3es, 4805-017, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-2335","authenticated-orcid":true,"given":"Hugo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Mesosystem Investiga\u00e7\u00e3o &amp; Investimentos by Spinpark, Barco, Guimar\u00e3es, 4805-017, Portugal"},{"name":"UCIBIO (Research Unit on Applied Molecular Science), REQUIMTE (Rede de Qu\u00edmica e Tecnologia), MEDTECH\n(Medicines and Healthcare Products), Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty\nof Pharmacy, University of Porto, Porto, 4050-313, Portugal"},{"name":"Associate Laboratory i4HB-Institute for Health\nand Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-3-030-69186-8_24","author":"Narouze S.N.","year":"2021","unstructured":"Narouze S.N.; Cannabinoids and pain: Mechanisms of action. 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