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Sera from heparinized (N=93) and non-heparinized\nindividuals (N=111) were tested for markers of acute HEV infection and anti-HEV IgG seroprevalence.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method::<\/jats:title>\n<jats:p>An acute HEV case was defined by the presence of anti-HEV IgM and\/or HEV RNA.\nFrom the 93 heparinized individuals, one was positive for IgM and IgG anti-HEV and two were\npositive for HEV RNA (for both ORF3 and ORF2), and there were a total of two (2.2%) cases of\ncurrent or recent HEV infection. From the 111 non-heparinized individuals, three were positive\nfor IgM anti-HEV, one was positive for both IgM and IgG anti-HEV, and none was positive for\nHEV RNA, and there were a total of three (2.7%) cases of current or recent HEV infection. The\ndifference between HEV cases in the heparinized individuals and the non-heparinized individuals\nwas not statistically significant (2.2% vs. 2.7%; p = 0.799).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results::<\/jats:title>\n<jats:p>Concerning IgG anti-HEV, it was detected in 32 individuals from the heparinized group\nand in 18 from the non-heparinized control group. A statistically significant difference was observed\nin the presence of anti-HEV IgG in heparinized individuals and controls (p = 0.003).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion::<\/jats:title>\n<jats:p>This study has not found any association between heparin treatment and acute HEV\ninfection, but has shown the use of therapeutic heparin as a risk factor for IgG anti-HEV seropositivity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115748863272272231122114732","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T07:01:43Z","timestamp":1704956503000},"page":"377-381","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hepatitis E Virus in Individuals Undergoing Heparin Therapy: An\nObservational Serological and Molecular Study"],"prefix":"10.2174","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-8103","authenticated-orcid":true,"given":"Jo\u00e3o R.","family":"Mesquita","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal"},{"name":"Epidemiology Research\nUnit (EPIUnit), Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o\nIntegrativa e Translacional em Sa\u00fade Populacional (ITR), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-5643","authenticated-orcid":true,"given":"S\u00e9rgio","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal"}]},{"given":"Nanci","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade\ndo Porto (FFUP), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-6889","authenticated-orcid":true,"given":"Antonio","family":"Rivero-Juarez","sequence":"additional","affiliation":[{"name":"CIBER Infectious Diseases (CIBERINFEC), Health Institute Carlos III,\n28029 Madrid, Spain"},{"name":"Grupo de Virolog\u00eda Cl\u00ednica y Zoonosis, Unidad de Enfermedades Infecciosas, Instituto\nMaim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, Hospital Reina Sof\u00eda, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"}]},{"given":"Guilherme","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Unidade de Sa\u00fade P\u00fablica do ACES Ave-Famalic\u00e3o, ARS Norte, Minist\u00e9rio da Sa\u00fade, Portugal"}]},{"given":"Maria","family":"S\u00e3o Jos\u00e9 Nascimento","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade\ndo Porto (FFUP), Porto, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1089\/fpd.2020.2896","volume":"18","author":"Ferri G.","year":"2021","unstructured":"Ferri G.; Vergara A.; Hepatitis E.; Hepatitis E virus in the food of animal origin: A review. 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