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The loss of mitochondrial function is related to the pathogenesis of several human diseases. Over the last decades, an increasing number of studies have shown that dietary polyphenols can regulate mitochondrial redox status, and in some cases, prevent or delay disease progression. This paper aims to review the role of four dietary polyphenols \u2013 resveratrol, curcumin, epigallocatechin-3-gallate nd quercetin \u2013 in molecular pathways regulated by mitochondria and their potential impact on human health. Cumulative evidence showed that the aforementioned polyphenols improve mitochondrial functions in different in vitro and in vivo experiments. The mechanisms underlying the polyphenols\u2019 beneficial effects include, among others, the attenuation of oxidative stress, the regulation of mitochondrial metabolism and biogenesis and the modulation of cell-death signaling cascades, among other mitochondrial-independent effects. The understanding of the chemicalbiological interactions of dietary polyphenols, namely with mitochondria, may have a huge impact on the treatment of mitochondrial dysfunction-related disorders.<\/jats:p><\/jats:sec>","DOI":"10.2174\/0929867324666170529101810","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T08:07:35Z","timestamp":1496131655000},"page":"3376-3406","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease"],"prefix":"10.2174","volume":"26","author":[{"given":"Jos\u00e9","family":"Teixeira","sequence":"first","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169- 007, Portugal"}]},{"given":"Daniel","family":"Chavarria","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169- 007, Portugal"}]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169- 007, Portugal"}]},{"given":"Lech","family":"Wojtczak","sequence":"additional","affiliation":[{"name":"Nencki Institute of Experimental Biology, Warsaw, Poland"}]},{"given":"Mariusz R.","family":"Wieckowski","sequence":"additional","affiliation":[{"name":"Nencki Institute of Experimental Biology, Warsaw, Poland"}]},{"given":"Agnieszka","family":"Karkucinska-Wieckowska","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland"}]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CNC \u2013 Center for Neuroscience and Cell Biology, UC-Biotech, Biocant Park \u2013 Cantanhede, University of Coimbra, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.bbadis.2016.03.010","volume":"1862","author":"S\u00e1daba M.C.","year":"2016","unstructured":"S\u00e1daba M.C.; Mart\u00edn-Estal I.; Puche J.E.; Castilla-Cort\u00e1zar I.; Insulin-like growth factor 1 (IGF-1) therapy: mitochondrial dysfunction and diseases. 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