{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:08:20Z","timestamp":1768727300488,"version":"3.49.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"39","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2019,1,17]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>The trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi and Leishmania\nspp, are causative agents of important human diseases such as African sleeping sickness,\nChagas\u2019 disease and Leishmaniasis, respectively. The high impact of these diseases\non human health and economy worldwide, the unsatisfactory available chemotherapeutic\noptions and the absence of human effective vaccines, strongly justifies the search for new\ndrugs. The pentose phosphate pathway has been proposed to be a viable strategy to defeat\nseveral infectious diseases, including those from trypanosomatids, as it includes an oxidative\nbranch, important in the maintenance of cell redox homeostasis, and a non-oxidative\nbranch in which ribose 5-phosphate and erythrose 4-phosphate, precursors of nucleic acids\nand aromatic amino acids, are produced. This review provides an overview of the\navailable chemotherapeutic options against these diseases and discusses the potential of\ngenetically validated enzymes from the pentose phosphate pathway of trypanosomatids to\nbe explored as potential drug targets.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867325666171206094752","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T14:34:48Z","timestamp":1512570888000},"page":"5239-5265","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Potential Drug Targets in the Pentose Phosphate Pathway of Trypanosomatids"],"prefix":"10.2174","volume":"25","author":[{"given":"In\u00eas","family":"Loureiro","sequence":"first","affiliation":[{"name":"Instituto de Investigacao e Inovacao em Sa\u00fade, Universidade do Porto, R. Alfredo Allen, 4200-135, Porto, Portugal"}]},{"given":"Joana","family":"Faria","sequence":"additional","affiliation":[{"name":"Instituto de Investigacao e Inovacao em Sa\u00fade, Universidade do Porto, R. Alfredo Allen, 4200-135, Porto, Portugal"}]},{"given":"Nuno","family":"Santarem","sequence":"additional","affiliation":[{"name":"Instituto de Investigacao e Inovacao em Sa\u00fade, Universidade do Porto, R. Alfredo Allen, 4200-135, Porto, Portugal"}]},{"given":"Terry K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Research Complex (BSRC), The North Haugh, The University, St. Andrews,Fife Scotland. KY16 9ST, United Kingdom"}]},{"given":"Joana","family":"Tavares","sequence":"additional","affiliation":[{"name":"Instituto de Investigacao e Inovacao em Sa\u00fade, Universidade do Porto, R. Alfredo Allen, 4200-135, Porto, Portugal"}]},{"given":"Anabela","family":"Cordeiro-da-Silva","sequence":"additional","affiliation":[{"name":"Instituto de Investigacao e Inovacao em Sa\u00fade, Universidade do Porto, R. Alfredo Allen, 4200-135, Porto, Portugal"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/158108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/158108\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/158108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:48:30Z","timestamp":1608889710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/158108\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":0,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2019,1,17]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867325666171206094752","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2017-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}