{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:49:54Z","timestamp":1773866994984,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"28","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2018,9,4]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Inflammatory Bowel Diseases (IBD) comprised of two disorders of idiopathic\nchronic intestinal inflammation that affect about three million people worldwide: Crohn\u2019s disease\nand ulcerative colitis. Nowadays, the first-line of treatment for patients with mild to\nmoderate symptoms of IBD is comprised of corticosteroids, immunosuppressants, antibiotics,\nand biological agents. Unfortunately, none of these drugs are curative, and their long-term use\nmay cause severe side effects and complications. Almost 40% of IBD patients use alternative\ntherapies to complement the conventional one, and flavonoids are gaining attention for this\npurpose. The biological properties of flavonoids are well documented and their antioxidant\nand anti-inflammatory activities have been arousing attention in the scientific community.\nFlavonoids are the most widely distributed polyphenols in plants and fruits, making part of\nthe human diet. Taking into account that all ingested flavonoids are expected to exert biological\nactions at the gastrointestinal level, research on the modulatory effect of these compounds\nin IBD is of paramount importance. This review intends to summarize, in an integrated and\ncomprehensive form, the effect of flavonoids, both in vitro and in vivo, in the different phases\nof the characteristic IBD inflammatory network.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867325666180214121734","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T06:27:12Z","timestamp":1518848832000},"page":"3374-3412","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Immunomodulatory Effects of Flavonoids in the Prophylaxis and Treatment of Inflammatory Bowel Diseases: A Comprehensive Review"],"prefix":"10.2174","volume":"25","author":[{"given":"Daniela","family":"Ribeiro","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Carina","family":"Proenca","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Silvia","family":"Rocha","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Jose L.F.C.","family":"Lima","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Felix","family":"Carvalho","sequence":"additional","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/159832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/159832\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/159832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:48:22Z","timestamp":1608889702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/159832\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,4]]},"references-count":0,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2018,9,4]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867325666180214121734","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,4]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2017-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}