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CRC\nincreased risk has been associated with alterations in the intestinal microbiota, with decreased\nproduction of Short Chain Fatty Acids (SCFAs). SCFAs produced in the human colon are the\nmajor products of bacterial fermentation of undigested dietary fiber and starch. While colonocytes\nuse the three major SCFAs, namely acetate, propionate and butyrate, as energy sources,\ntransformed CRC cells primarily undergo aerobic glycolysis. Compared to normal colonocytes,\nCRC cells exhibit increased sensitivity to SCFAs, thus indicating they play an important\nrole in cell homeostasis. Manipulation of SCFA levels in the intestine, through changes in\nmicrobiota, has therefore emerged as a potential preventive\/therapeutic strategy for CRC. Interest\nin understanding SCFAs mechanism of action in CRC cells has increased in the last\nyears. Several SCFA transporters like SMCT-1, MCT-1 and aquaporins have been identified\nas the main transmembrane transporters in intestinal cells. Recently, it was shown that acetate\npromotes plasma membrane re-localization of MCT-1 and triggers changes in the glucose metabolism.\nSCFAs induce apoptotic cell death in CRC cells, and further mechanisms have been\ndiscovered, including the involvement of lysosomal membrane permeabilization, associated\nwith mitochondria dysfunction and degradation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>In this review, we will discuss the current knowledge on the transport of SCFAs by CRC cells\nand their effects on CRC metabolism and survival. The impact of increasing SCFA production\nby manipulation of colon microbiota on the prevention\/therapy of CRC will also be addressed.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867325666180530102050","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T07:34:58Z","timestamp":1527752098000},"page":"4087-4108","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications"],"prefix":"10.2174","volume":"27","author":[{"given":"Sara Daniela","family":"Gomes","sequence":"first","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Cl\u00e1udia Suellen","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Jo\u00e3o","family":"Azevedo-Silva","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Marta R.","family":"Casanova","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Judite","family":"Barreto","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Helena","family":"Pereira","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Susana R.","family":"Chaves","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"L\u00edgia R.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal"}]},{"given":"Margarida","family":"Casal","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Manuela","family":"C\u00f4rte-Real","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"F\u00e1tima","family":"Baltazar","sequence":"additional","affiliation":[{"name":"ICVS - Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal"}]},{"given":"Ana","family":"Preto","sequence":"additional","affiliation":[{"name":"CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"Torre L.A.","year":"2015","unstructured":"Torre L.A.; Bray F.; Siegel R.L.; Ferlay J.; Lortet-Tieulent J.; Jemal A.; Global cancer statistics, 2012. 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