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Amongst the\nstrategies to overcome this obstacle, liposomes are interesting vehicles for delivering the drugs into the\nskin, the synovial cavity or other regions affected by inflammatory or degenerative conditions.\nLiposomes are lipid carriers of nanometric size formed by phospholipid bilayers. They have the advantages\nof preparation feasibility and biological compatibility associated with the possibility of carrying\neither lipophylic and\/or hydrophylic compounds, and have been extensively used in various drug delivery\nsystems, for drug targeting, controlled release and permeation enhancement of drugs. Conventional\nliposomes are not very stable and not suitable for dermal administration after topical application, since\nthey accumulate on the skin surface due to the rigidity of the lipid layers and suffer dehydration, culminating\nin their fragmentation. Other formulations have emerged in the meantime, such as transfersomes,\nniosomes or ethosomes. The present work consists of a review on the published scientific papers regarding\nthe development of liposomal formulations containing non-steroidal anti-inflammatory drugs for the\npurpose of relieving the symptomatology of inflammatory and degenerative ailments. The exposition\nsummarizes data relating to liposome type, composition, preparation method, liposome characterization,\ntopical vehicle used, in vitro permeation studies performed, in vivo anti-inflammatory assays carried out\nand results obtained in the different studies published in the last five years.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867326666190227233321","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T12:03:15Z","timestamp":1551700995000},"page":"3809-3829","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Non-Steroidal Anti-Inflammatory Drugs Loaded Liposomes for Topical Treatment of Inflammatory and Degenerative Conditions"],"prefix":"10.2174","volume":"27","author":[{"given":"Carla","family":"Matos","sequence":"first","affiliation":[{"name":"FP-ENAS-UFP Energy, Environment and Health Research Unit\/CEBIMED-Centro de Estudos em Biomedicina, Fernando Pessoa University, Porto, Portugal"}]},{"given":"Paulo","family":"Lob\u00e3o","sequence":"additional","affiliation":[{"name":"Research Centre for Pharmaceutical Sciences, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/newbio231232a0","volume":"231","author":"Vane J.R.","year":"1971","unstructured":"Vane J.R.; Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. 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