{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:37:56Z","timestamp":1774928276936,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"22","funder":[{"DOI":"10.13039\/501100019370","name":"FCT Scientific Employment Stimulus","doi-asserted-by":"publisher","award":["CEECIND\/00425\/2017"],"award-info":[{"award-number":["CEECIND\/00425\/2017"]}],"id":[{"id":"10.13039\/501100019370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019370","name":"FCT-Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}],"id":[{"id":"10.13039\/501100019370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,8,2]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Cancer is the world\u2019s leading cause of death after heart diseases and involves abnormal\ncell growth at a primary site and the potential to spread to other parts of the body. Tumors\nare highly heterogeneous and consist of subgroups of cells with distinct characteristics.\nOf these, the cancer stem cells (CSC) niche plays a crucial role in driving the spread of the\ntumor and are thought to provide treatment resistance. CSC is a rare special population of cancer\ncells exhibiting high tumorigenic properties together with self-renewal and differentiation\ncapability. CSC is not only linked with high tumor-initiating activity, but is also implicated in\nchemotherapeutic resistance, metastasis, epithelial to mesenchymal transition, and recurrence.\nThereafter, novel therapeutic strategies targeting CSC are in need to improve long-term clinical\noutcomes. The literature supports the evidence that marine natural compounds can exhibit\nantioxidant, antimitotic, anti-inflammatory, antibiotic as well as anticancer activity. In this\nreview, we will provide an insight into the relevance of selected marine natural products as a\nsource of bioactive compounds with anti-cancer properties to target CSC, which may benefit\nthe development of novel anti-cancer therapeutic strategies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867327666200320155053","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T13:38:48Z","timestamp":1584711528000},"page":"4343-4355","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Marine Natural Products as a Promising Source of Therapeutic Compounds to Target Cancer Stem Cells"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-7231","authenticated-orcid":true,"given":"Catarina","family":"Vizetto-Duarte","sequence":"first","affiliation":[{"name":"School of Material Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3453-3978","authenticated-orcid":true,"given":"Pedro","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Medicine, University of Algarve, Ed. 2 \u2013 Ala Norte, Campus of Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-7703","authenticated-orcid":true,"given":"Lu\u00edsa","family":"Cust\u00f3dio","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, Faculty of Sciences and Technology, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/180448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/180448\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/180448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T10:04:42Z","timestamp":1628071482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/180448\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":0,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,8,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867327666200320155053","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}