{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:47:32Z","timestamp":1778273252247,"version":"3.51.4"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"37","funder":[{"name":"Programme for Competitiveness and Internationalisation","award":["POCI-01-0145-FEDER-028931"],"award-info":[{"award-number":["POCI-01-0145-FEDER-028931"]}]},{"DOI":"10.13039\/501100001871","name":"Applied Molecular Biosciences Unit - UCIBIO-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2021,11,26]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Reactive oxygen\/nitrogen species (ROS\/RNS) are produced physiologically by\nseveral mechanisms, especially during the inflammatory response. However, their overproduction\ncan lead to the evolution of conditions known as oxidative\/nitrosative stress,\nresulting in the establishment of chronic inflammatory diseases. Chalcones are considered\nas a class of flavonoids having the molecular pattern 1,3-diaryl-2-propen-1-one. In the last\nfew years, the antioxidant property of chalcones has been extensively studied, mainly due\nto their ability to inhibit the production or scavenging ROS\/RNS. The antioxidant activity\nof chalcones, focusing on the production of ROS\/RNS during the inflammatory response,\nis demonstrated and discussed in the present review. This literature revision was based on\nthe modulatory effects of chalcones against different enzymes, such as superoxide dismutase\n(SOD), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, catalase\n(CAT), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS), and, in the\nscavenging of ROS\/RNS. Whenever possible, the structure-activity relationship (SAR)\nwas established. Through the analysis accomplished in this review, it can be observed that\nthe presence of substituents, e.g. hydroxyl, methoxyl, prenyl, and halogen atoms in the\nchalcones scaffold, often occurs and can improve their modulatory activities, namely, in\nthe production of ROS\/RNS during the inflammatory response.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867328666210511014949","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T12:26:25Z","timestamp":1621167985000},"page":"7658-7713","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Antioxidant Effects of Chalcones during the Inflammatory Response: An Overall Review"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-7329","authenticated-orcid":true,"given":"Thaise","family":"Martins","sequence":"first","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-5591","authenticated-orcid":true,"given":"Bruno M.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2330-7537","authenticated-orcid":true,"given":"Irene","family":"Rebelo","sequence":"additional","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/193288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/193288\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/193288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T13:37:57Z","timestamp":1638970677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/193288\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":0,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2021,11,26]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867328666210511014949","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}