{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:50:14Z","timestamp":1740142214080,"version":"3.37.3"},"reference-count":128,"publisher":"Bentham Science Publishers Ltd.","issue":"37","funder":[{"DOI":"10.13039\/501100006109","name":"VEGA","doi-asserted-by":"publisher","award":["2\/0120\/22","APVV-20-0243"],"award-info":[{"award-number":["2\/0120\/22","APVV-20-0243"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para, Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIO\/04469\/2020"],"award-info":[{"award-number":["UID\/BIO\/04469\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"COMPETE 2020","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-006684"],"award-info":[{"award-number":["POCI-01-0145-FEDER-006684"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Biomarkers are characteristic molecules that can be measured as indicators of biological process status or condition, exhibiting special relevance in Parkinson\u2019s Disease (PD). This disease is a chronic neurodegenerative disorder very difficult to study given the site of pathology and due to a clinical phenotype that fluctuates over time. Currently there is no definitive diagnostic test, thus clinicians hope that the detection of crucial biomarkers will help to the symptomatic and presymptomatic diagnostics and providing surrogate endpoints to demonstrate the clinical efficacy of new treatments.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Electrochemical aptasensors are excellent analytical tools that are used in the detection of PD biomarkers, as they are portable, easy to use, and perform real-time analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>In this review, we discuss the most important clinical biomarkers for PD, highlighting their physiological role and function in the disease. Herein, we review for the first time innovative aptasensors for the detection of current potential PD biomarkers based on electrochemical techniques and discuss future alternatives, including ideal analytical platforms for point-of-care diagnostics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>These new tools will be critical not only in the discovery of sensitive, specific, and reliable biomarkers of preclinical PD, but also in the development of tests that can assist in the early detection and differential diagnosis of parkinsonian disorders and in monitoring disease progression. Various methods for fixing aptamers onto the sensor surfaces, enabling quantitative and specific PD biomarker detection present in synthetic and clinical samples, will also be discussed.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867329666220520123337","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T05:16:26Z","timestamp":1653628586000},"page":"5795-5814","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Electrochemical Aptasensors for Parkinson\u2019s Disease Biomarkers Detection"],"prefix":"10.2174","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-5770","authenticated-orcid":true,"given":"Edyta","family":"Miku\u0142a","sequence":"first","affiliation":[{"name":"Department of Biosensors, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences,\nTuwima 10, Olsztyn 10-748, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-9298","authenticated-orcid":true,"given":"Jaroslav","family":"Katrl\u00edk","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Slovak Academy of Sciences, D\u00fabravsk\u00e1\ncesta 9, Bratislava 84538, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9265-0630","authenticated-orcid":true,"given":"Ligia R.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering, Universidade do Minho, Campus de\nGualtar, Braga 4710-057, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev.biochem.74.082803.133400","volume":"74","author":"Cookson M.R.","year":"2005","unstructured":"Cookson M.R.; The biochemistry of Parkinson\u2019s disease. Annu Rev Biochem 2005,74(1),29-52","journal-title":"Annu Rev Biochem"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2174\/0929866043407138","volume":"11","author":"Martin F.","year":"2004","unstructured":"Martin F.; Williamson S.; Paleologou K.; Allsop D.; El-Agnaf O.; Alpha-synuclein and the pathogenesis of Parkinson\u2019s disease. Protein Pept Lett 2004,11(3),229-237","journal-title":"Protein Pept Lett"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/bpa.12370","volume":"26","author":"Atik A.","year":"2016","unstructured":"Atik A.; Stewart T.; Zhang J.; Alpha-synuclein as a biomarker for Parkinson\u2019s disease. Brain Pathol 2016,26(3),410-418","journal-title":"Brain Pathol"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","volume":"339","author":"Lang A.E.","year":"1998","unstructured":"Lang A.E.; Lozano A.M.; Parkinson\u2019s disease. N Engl J Med 1998,339(15),1044-1053","journal-title":"N Engl J Med"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3109\/00207454.2014.961454","volume":"125","author":"Gao L.","year":"2015","unstructured":"Gao L.; Tang H.; Nie K.; Wang L.; Zhao J.; Gan R.; Huang J.; Zhu R.; Feng S.; Duan Z.; Zhang Y.; Wang L.; Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson\u2019s disease diagnosis: A systematic review and meta-analysis. Int J Neurosci 2015,125(9),645-654","journal-title":"Int J Neurosci"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.drudis.2012.09.001","volume":"18","author":"Wang J.","year":"2013","unstructured":"Wang J.; Hoekstra J.G.; Zuo C.; Cook T.J.; Zhang J.; Biomarkers of Parkinson\u2019s disease: Current status and future perspectives. Drug Discov Today 2013,18(3-4),155-162","journal-title":"Drug Discov Today"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/S1474-4422(11)70014-X","volume":"10","author":"Mollenhauer B.","year":"2011","unstructured":"Mollenhauer B.; Locascio J.J.; Schulz-Schaeffer W.; Sixel-D\u00f6ring F.; Trenkwalder C.; Schlossmacher M.G.; \u03b1-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: A cohort study. Lancet Neurol 2011,10(3),230-240","journal-title":"Lancet Neurol"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"4247","DOI":"10.1016\/j.bmcl.2017.07.075","volume":"27","author":"Ellis J.M.","year":"2017","unstructured":"Ellis J.M.; Fell M.J.; Current approaches to the treatment of Parkinson\u2019s disease. Bioorg Med Chem Lett 2017,27(18),4247-4255","journal-title":"Bioorg Med Chem Lett"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1517\/14740338.2016.1130128","volume":"15","author":"Ceravolo R.","year":"2016","unstructured":"Ceravolo R.; Rossi C.; Del Prete E.; Bonuccelli U.; A review of adverse events linked to dopamine agonists in the treatment of Parkinson\u2019s disease. Expert Opin Drug Saf 2016,15(2),181-198","journal-title":"Expert Opin Drug Saf"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3389\/fnins.2018.00612","volume":"12","author":"Emamzadeh F.N.","year":"2018","unstructured":"Emamzadeh F.N.; Surguchov A.; Parkinson\u2019s disease: Biomarkers, treatment, and risk factors. Front Neurosci 2018,12,612","journal-title":"Front Neurosci"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/ana.1049","volume":"50","author":"Berendse H.W.","year":"2001","unstructured":"Berendse H.W.; Booij J.; Francot C.M.J.E.; Bergmans P.L.M.; Hijman R.; Stoof J.C.; Wolters E.C.; Subclinical dopaminergic dysfunction in asymptomatic Parkinson\u2019s disease patients\u2019 relatives with a decreased sense of smell. Ann Neurol 2001,50(1),34-41","journal-title":"Ann Neurol"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1093\/brain\/awv040","volume":"138","author":"Roberts R.F.","year":"2015","unstructured":"Roberts R.F.; Wade-Martins R.; Alegre-Abarrategui J.; Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson\u2019s disease brain. Brain 2015,138(6),1642-1657","journal-title":"Brain"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2217\/fnl.11.7","volume":"6","author":"Mukaetova-Ladinska E.B.","year":"2011","unstructured":"Mukaetova-Ladinska E.B.; Parkinson\u2019s disease: Diagnostic relevance of elevated levels of soluble \u03b1-synuclein oligomers in cerebrospinal fluid. Future Neurol 2011,6(2),159-163","journal-title":"Future Neurol"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/alzrt255","volume":"6","author":"Hansson O.","year":"2014","unstructured":"Hansson O.; Hall S.; \u00d6hrfelt A.; Zetterberg H.; Blennow K.; Minthon L.; N\u00e4gga K.; Londos E.; Varghese S.; Majbour N.K.; Al-Hayani A.; El-Agnaf O.M.; Levels of cerebrospinal fluid \u03b1-synuclein oligomers are increased in Parkinson\u2019s disease with dementia and dementia with Lewy bodies compared to Alzheimer\u2019s disease. Alzheimers Res Ther 2014,6(3),25","journal-title":"Alzheimers Res Ther"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3988\/jcn.2011.7.4.215","volume":"7","author":"Park M.J.","year":"2011","unstructured":"Park M.J.; Cheon S.M.; Bae H.R.; Kim S.H.; Kim J.W.; Elevated levels of \u03b1-synuclein oligomer in the cerebrospinal fluid of drug-na\u00efve patients with Parkinson\u2019s disease. J Clin Neurol 2011,7(4),215-222","journal-title":"J Clin Neurol"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neulet.2015.05.030","volume":"599","author":"Wang X.","year":"2015","unstructured":"Wang X.; Yu S.; Li F.; Feng T.; Detection of \u03b1-synuclein oligomers in red blood cells as a potential biomarker of Parkinson\u2019s disease. Neurosci Lett 2015,599,115-119","journal-title":"Neurosci Lett"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1096\/fj.03-1449com","volume":"20","author":"El-Agnaf O.M.A.","year":"2006","unstructured":"El-Agnaf O.M.A.; Salem S.A.; Paleologou K.E.; Curran M.D.; Gibson M.J.; Court J.A.; Schlossmacher M.G.; Allsop D.; Detection of oligomeric forms of \u03b1-synuclein protein in human plasma as a potential biomarker for Parkinson\u2019s disease. FASEB J 2006,20(3),419-425","journal-title":"FASEB J"},{"key":"ref=18","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/brain\/awn349","volume":"132","author":"Paleologou K.E.","year":"2009","unstructured":"Paleologou K.E.; Kragh C.L.; Mann D.M.; Salem S.A.; Al-Shami R.; Allsop D.; Hassan A.H.; Jensen P.H.; El-Agnaf O.M.; Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain 2009,132(Pt 4),1093-1101","journal-title":"Brain"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"e0151156","DOI":"10.1371\/journal.pone.0151156","volume":"11","author":"Vivacqua G.","year":"2016","unstructured":"Vivacqua G.; Latorre A.; Suppa A.; Nardi M.; Pietracupa S.; Mancinelli R.; Fabbrini G.; Colosimo C.; Gaudio E.; Berardelli A.; Abnormal salivary total and oligomeric alpha-synuclein in Parkinson\u2019s disease. PLoS One 2016,11(3),e0151156","journal-title":"PLoS One"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1039\/c1ib00018g","volume":"3","author":"Sierks M.R.","year":"2011","unstructured":"Sierks M.R.; Chatterjee G.; McGraw C.; Kasturirangan S.; Schulz P.; Prasad S.; CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease. Integr Biol 2011,3(12),1188-1196","journal-title":"Integr Biol"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"5542","DOI":"10.1021\/ac300330g","volume":"84","author":"Tsukakoshi K.","year":"2012","unstructured":"Tsukakoshi K.; Abe K.; Sode K.; Ikebukuro K.; Selection of DNA aptamers that recognize \u03b1-synuclein oligomers using a competitive screening method. Anal Chem 2012,84(13),5542-5547","journal-title":"Anal Chem"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.snb.2012.05.077","volume":"171-172","author":"Qureshi A.","year":"2012","unstructured":"Qureshi A.; Gurbuz Y.; Niazi J.H.; Biosensors for cardiac biomarkers detection: A review. Sens Actuators B Chem 2012,171-172,62-76","journal-title":"Sens Actuators B Chem"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.cca.2021.03.009","volume":"518","author":"Mobed A.","year":"2021","unstructured":"Mobed A.; Razavi S.; Ahmadalipour A.; Shakouri S.K.; Koohkan G.; Biosensors in Parkinson\u2019s disease. Clin Chim Acta 2021,518,51-58","journal-title":"Clin Chim Acta"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1042\/EBC20150010","volume":"60","author":"Damborsk\u00fd P.","year":"2016","unstructured":"Damborsk\u00fd P.; \u0160vitel J.; Katrl\u00edk J.; Optical biosensors. Essays Biochem 2016,60(1),91-100","journal-title":"Essays Biochem"},{"key":"ref=25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0956-5663(01)00115-4","volume":"16","author":"Th\u00e9venot D.R.","year":"2001","unstructured":"Th\u00e9venot D.R.; Toth K.; Durst R.A.; Wilson G.S.; Electrochemical biosensors: Recommended definitions and classification. Biosens Bioelectron 2001,16(1-2),121-131","journal-title":"Biosens Bioelectron"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bioelechem.2009.04.007","volume":"77","author":"Cheng A.K.H.","year":"2009","unstructured":"Cheng A.K.H.; Sen D.; Yu H.Z.; Design and testing of aptamer-based electrochemical biosensors for proteins and small molecules. Bioelectrochemistry 2009,77(1),1-12","journal-title":"Bioelectrochemistry"},{"key":"ref=27","author":"Scheller F.","year":"1992","unstructured":"Scheller F.; Schubert F.;  Biosensors 1992","journal-title":"Biosensors"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1351\/pac200476040723","volume":"76","author":"Rodriguez-Mozaz S.","year":"2004","unstructured":"Rodriguez-Mozaz S.; Marco M.P.; de Alda M.J.L.; Barcel\u00f3 D.; Biosensors for environmental applications: Future development trends. Pure Appl Chem 2004,76(4),723-752","journal-title":"Pure Appl Chem"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1002\/elan.200904566","volume":"21","author":"Hianik T.","year":"2009","unstructured":"Hianik T.; Wang J.; Electrochemical aptasensors-recent achievements and perspectives. Electroanalysis 2009,21(11),1223-1235","journal-title":"Electroanalysis"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4061\/2011\/863196","volume":"2011","author":"Radi A.E.","year":"2011","unstructured":"Radi A.E.; Electrochemical aptamer-based biosensors: Recent advances and perspectives. Int J Electrochem 2011,2011,1-17","journal-title":"Int J Electrochem"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/346818a0","volume":"346","author":"Ellington A.D.","year":"1990","unstructured":"Ellington A.D.; Szostak J.W.; In vitro selection of RNA molecules that bind specific ligands. Nature 1990,346(6287),818-822","journal-title":"Nature"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.biotechadv.2016.05.006","volume":"34","author":"Meirinho S.G.","year":"2016","unstructured":"Meirinho S.G.; Dias L.G.; Peres A.M.; Rodrigues L.R.; Voltammetric aptasensors for protein disease biomarkers detection: A review. Biotechnol Adv 2016,34(5),941-953","journal-title":"Biotechnol Adv"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"12411","DOI":"10.3390\/ijms140612411","volume":"14","author":"Stefani M.","year":"2013","unstructured":"Stefani M.; Rigacci S.; Protein folding and aggregation into amyloid: The interference by natural phenolic compounds. Int J Mol Sci 2013,14(6),12411-12457","journal-title":"Int J Mol Sci"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.bios.2016.04.011","volume":"82","author":"Robati R.Y.","year":"2016","unstructured":"Robati R.Y.; Arab A.; Ramezani M.; Langroodi F.A.; Abnous K.; Taghdisi S.M.; Aptasensors for quantitative detection of kanamycin. Biosens Bioelectron 2016,82(82),162-172","journal-title":"Biosens Bioelectron"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.trac.2015.05.012","volume":"74","author":"van den Kieboom C.H.","year":"2015","unstructured":"van den Kieboom C.H.; van der Beek S.L.; M\u00e9sz\u00e1ros T.; Gyurcs\u00e1nyi R.E.; Ferwerda G.; de Jonge M.I.; Aptasensors for viral diagnostics. Trends Analyt Chem 2015,74,58-67","journal-title":"Trends Analyt Chem"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.aca.2019.09.013","volume":"1089","author":"Hassan Q.","year":"2019","unstructured":"Hassan Q.; Li S.; Ferrag C.; Kerman K.; Electrochemical biosensors for the detection and study of \u03b1-synuclein related to Parkinson\u2019s disease: A review. Anal Chim Acta 2019,1089,32-39","journal-title":"Anal Chim Acta"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1097\/COH.0b013e32833ed177","volume":"5","author":"Strimbu K.","year":"2010","unstructured":"Strimbu K.; Tavel J.A.; What are biomarkers? Curr Opin HIV AIDS 2010,5(6),463-466","journal-title":"Curr Opin HIV AIDS"},{"key":"ref=38","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89891-7_20","author":"Hess S.","year":"2011","unstructured":"Hess S.; Ozoux M.L.; Gerl M.;  Drug Discovery and Evaluation: Methods in Clinical Pharmacology 2011","journal-title":"Drug Discovery and Evaluation: Methods in Clinical Pharmacology"},{"journal-title":"Environmental Health Criteria 155 Biomarkers and risk assessment: Concepts and principles","year":"1993","key":"ref=39","unstructured":"Environmental Health Criteria 155 Biomarkers and risk assessment: Concepts and principles 1993"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1093\/brain\/awh198","volume":"127","author":"Michell A.W.","year":"2004","unstructured":"Michell A.W.; Lewis S.J.G.; Foltynie T.; Barker R.A.; Biomarkers and Parkinson\u2019s disease. Brain 2004,127(8),1693-1705","journal-title":"Brain"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00702-012-0840-9","volume":"120","author":"Kansara S.","year":"2013","unstructured":"Kansara S.; Trivedi A.; Chen S.; Jankovic J.; Le W.; Early diagnosis and therapy of Parkinson\u2019s disease: Can disease progression be curbed? J Neural Transm (Vienna) 2013,120(1),197-210","journal-title":"J Neural Transm (Vienna)"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.3233\/JPD-179005","volume":"7","author":"Goedert M.","year":"2017","unstructured":"Goedert M.; Jakes R.; Spillantini M.G.; The synucleinopathies: Twenty years on. J Parkinsons Dis 2017,7(s1),S51-S69","journal-title":"J Parkinsons Dis"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"12334","DOI":"10.1074\/jbc.M110414200","volume":"277","author":"Ahn B.H.","year":"2002","unstructured":"Ahn B.H.; Rhim H.; Kim S.Y.; Sung Y.M.; Lee M.Y.; Choi J.Y.; Wolozin B.; Chang J.S.; Lee Y.H.; Kwon T.K.; Chung K.C.; Yoon S.H.; Hahn S.J.; Kim M.S.; Jo Y.H.; Min D.S.; alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem 2002,277(14),12334-12342","journal-title":"J Biol Chem"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"Polymeropoulos M.H.","year":"1997","unstructured":"Polymeropoulos M.H.; Lavedan C.; Leroy E.; Ide S.E.; Dehejia A.; Dutra A.; Pike B.; Root H.; Rubenstein J.; Boyer R.; Stenroos E.S.; Chandrasekharappa S.; Athanassiadou A.; Papapetropoulos T.; Johnson W.G.; Lazzarini A.M.; Duvoisin R.C.; Di Iorio G.; Golbe L.I.; Nussbaum R.L.; Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease. Science 1997,276(5321),2045-2047","journal-title":"Science"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/ana.410270309","volume":"27","author":"Golbe L.I.","year":"1990","unstructured":"Golbe L.I.; Di Iorio G.; Bonavita V.; Miller D.C.; Duvoisin R.C.; A large kindred with autosomal dominant Parkinson\u2019s disease. Ann Neurol 1990,27(3),276-282","journal-title":"Ann Neurol"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1126\/science.274.5290.1197","volume":"274","author":"Polymeropoulos M.H.","year":"1996","unstructured":"Polymeropoulos M.H.; Higgins J.J.; Golbe L.I.; Johnson W.G.; Ide S.E.; Di Iorio G.; Sanges G.; Stenroos E.S.; Pho L.T.; Schaffer A.A.; Lazzarini A.M.; Nussbaum R.L.; Duvoisin R.C.; Mapping of a gene for Parkinson\u2019s disease to chromosome 4q21-q23. Science 1996,274(5290),1197-1199","journal-title":"Science"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13024-019-0329-1","volume":"14","author":"Meade R.M.","year":"2019","unstructured":"Meade R.M.; Fairlie D.P.; Mason J.M.; Alpha-synuclein structure and Parkinson\u2019s disease-lessons and emerging principles. Mol Neurodegener 2019,14(1),29","journal-title":"Mol Neurodegener"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.bbapap.2019.03.001","volume":"1867","author":"Mehra S.","year":"2019","unstructured":"Mehra S.; Sahay S.; Maji S.K.; \u03b1-Synuclein misfolding and aggregation: Implications in Parkinson\u2019s disease pathogenesis. Biochim Biophys Acta Proteins Proteomics 2019,1867(10),890-908","journal-title":"Biochim Biophys Acta Proteins Proteomics"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrn3406","volume":"14","author":"Lashuel H.A.","year":"2013","unstructured":"Lashuel H.A.; Overk C.R.; Oueslati A.; Masliah E.; The many faces of \u03b1-synuclein: From structure and toxicity to therapeutic target. Nat Rev Neurosci 2013,14(1),38-48","journal-title":"Nat Rev Neurosci"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3389\/fnins.2016.00408","volume":"10","author":"Ingelsson M.","year":"2016","unstructured":"Ingelsson M.; Alpha-synuclein oligomers- neurotoxic molecules in Parkinson\u2019s disease and other lewy body disorders. Front Neurosci 2016,10,408","journal-title":"Front Neurosci"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.toxlet.2016.11.002","volume":"265","author":"Zhang Q.S.","year":"2017","unstructured":"Zhang Q.S.; Heng Y.; Yuan Y.H.; Chen N.H.; Pathological \u03b1-synuclein exacerbates the progression of Parkinson\u2019s disease through microglial activation. Toxicol Lett 2017,265,30-37","journal-title":"Toxicol Lett"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.biochi.2017.12.015","volume":"147","author":"Shui B.","year":"2018","unstructured":"Shui B.; Tao D.; Florea A.; Cheng J.; Zhao Q.; Gu Y.; Li W.; Jaffrezic-Renault N.; Mei Y.; Guo Z.; Biosensors for Alzheimer\u2019s disease biomarker detection: A review. Biochimie 2018,147,13-24","journal-title":"Biochimie"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrn3887","volume":"16","author":"Brettschneider J.","year":"2015","unstructured":"Brettschneider J.; Tredici K.D.; Lee V.M.Y.; Trojanowski J.Q.; Spreading of pathology in neurodegenerative diseases: A focus on human studies. Nat Rev Neurosci 2015,16(2),109-120","journal-title":"Nat Rev Neurosci"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nm.3457","volume":"20","author":"Guo J.L.","year":"2014","unstructured":"Guo J.L.; Lee V.M.Y.; Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat Med 2014,20(2),130-138","journal-title":"Nat Med"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/jnc.13449","volume":"139","author":"Tyson T.","year":"2016","unstructured":"Tyson T.; Steiner J.A.; Brundin P.; Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology. J Neurochem 2016,139(Suppl. 1),275-289","journal-title":"J Neurochem"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.neurobiolaging.2009.04.016","volume":"32","author":"Srikanth V.","year":"2011","unstructured":"Srikanth V.; Maczurek A.; Phan T.; Steele M.; Westcott B.; Juskiw D.; M\u00fcnch G.; Advanced glycation endproducts and their receptor RAGE in Alzheimer\u2019s disease. Neurobiol Aging 2011,32(5),763-777","journal-title":"Neurobiol Aging"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s12031-020-01776-5","volume":"71","author":"Pan L.","year":"2021","unstructured":"Pan L.; Meng L.; He M.; Zhang Z.; Tau in the pathophysiology of Parkinson\u2019s disease. J Mol Neurosci 2021,71(11),2179-2191","journal-title":"J Mol Neurosci"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1212\/WNL.0b013e3181fd613b","volume":"75","author":"Tokuda T.","year":"2010","unstructured":"Tokuda T.; Qureshi M.M.; Ardah M.T.; Varghese S.; Shehab S.A.S.; Kasai T.; Ishigami N.; Tamaoka A.; Nakagawa M.; El-Agnaf O.M.A.; Detection of elevated levels of-synuclein oligomers in CSF from patients with Parkinson disease. Neurology 2010,75(20),1766-1770","journal-title":"Neurology"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"a006247","DOI":"10.1101\/cshperspect.a006247","volume":"2","author":"Mandelkow E.M.","year":"2012","unstructured":"Mandelkow E.M.; Mandelkow E.; Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med 2012,2(7),a006247","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1016\/j.biocel.2010.07.016","volume":"42","author":"Lei P.","year":"2010","unstructured":"Lei P.; Ayton S.; Finkelstein D.I.; Adlard P.A.; Masters C.L.; Bush A.I.; Tau protein: Relevance to Parkinson\u2019s disease. Int J Biochem Cell Biol 2010,42(11),1775-1778","journal-title":"Int J Biochem Cell Biol"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","volume":"31","author":"De Vos K.J.","year":"2008","unstructured":"De Vos K.J.; Grierson A.J.; Ackerley S.; Miller C.C.J.; Role of axonal transport in neurodegenerative diseases. Annu Rev Neurosci 2008,31(1),151-173","journal-title":"Annu Rev Neurosci"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.tins.2004.01.007","volume":"27","author":"Lee V.M.Y.","year":"2004","unstructured":"Lee V.M.Y.; Giasson B.I.; Trojanowski J.Q.; More than just two peas in a pod: Common amyloidogenic properties of tau and \u03b1-synuclein in neurodegenerative diseases. Trends Neurosci 2004,27(3),129-134","journal-title":"Trends Neurosci"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.biopsych.2017.12.018","volume":"84","author":"Castillo-Carranza D.L.","year":"2018","unstructured":"Castillo-Carranza D.L.; Guerrero-Mu\u00f1oz M.J.; Sengupta U.; Gerson J.E.; Kayed R.; \u03b1-synuclein oligomers induce a unique toxic tau strain. Biol Psychiatry 2018,84(7),499-508","journal-title":"Biol Psychiatry"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1126\/science.1082324","volume":"300","author":"Giasson B.I.","year":"2003","unstructured":"Giasson B.I.; Forman M.S.; Higuchi M.; Golbe L.I.; Graves C.L.; Kotzbauer P.T.; Trojanowski J.Q.; Lee V.M.Y.; Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003,300(5619),636-640","journal-title":"Science"},{"key":"ref=65","author":"Chen W.","year":"2016","unstructured":"Chen W.;  UC Irvine Electronic Theses and Dissertations 2016 https:\/\/escholarship.org\/uc\/item\/78t3557g","journal-title":"UC Irvine Electronic Theses and Dissertations"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1096\/fj.06-6092com","volume":"20","author":"Duka T.","year":"2006","unstructured":"Duka T.; Rusnak M.; Drolet R.E.; Duka V.; Wersinger C.; Goudreau J.L.; Sidhu A.; Alpha-Synuclein induces hyperphosphorylation of Tau in the MPTP model of Parkinsonism. FASEB J 2006,20(13),2302-2312","journal-title":"FASEB J"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1111\/j.1460-9568.2011.07660.x","volume":"33","author":"Haggerty T.","year":"2011","unstructured":"Haggerty T.; Credle J.; Rodriguez O.; Wills J.; Oaks A.W.; Masliah E.; Sidhu A.; Hyperphosphorylated Tau in an \u03b1-synuclein-overexpressing transgenic model of Parkinson\u2019s disease. Eur J Neurosci 2011,33(9),1598-1610","journal-title":"Eur J Neurosci"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/cercor\/11.12.1136","volume":"11","author":"Cools R.","year":"2001","unstructured":"Cools R.; Barker R.A.; Sahakian B.J.; Robbins T.W.; Enhanced or impaired cognitive function in Parkinson\u2019s disease as a function of dopaminergic medication and task demands. Cereb Cortex 2001,11(12),1136-1143","journal-title":"Cereb Cortex"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.tins.2007.03.009","volume":"30","author":"Sulzer D.","year":"2007","unstructured":"Sulzer D.; Multiple hit hypotheses for dopamine neuron loss in Parkinson\u2019s disease. Trends Neurosci 2007,30(5),244-250","journal-title":"Trends Neurosci"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0306-4522(92)90099-N","volume":"49","author":"Chinaglia G.","year":"1992","unstructured":"Chinaglia G.; Alvarez F.J.; Probst A.; Palacios J.M.; Mesostriatal and mesolimbic dopamine uptake binding sites are reduced in Parkinson\u2019s disease and progressive supranuclear palsy: A quantitative autoradiographic study using [3H]mazindol. Neuroscience 1992,49(2),317-327","journal-title":"Neuroscience"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/ana.410260403","volume":"26","author":"German D.C.","year":"1989","unstructured":"German D.C.; Manaye K.; Smith W.K.; Woodward D.J.; Saper C.B.; Midbrain dopaminergic cell loss in Parkinson\u2019s disease: Computer visualization. Ann Neurol 1989,26(4),507-514","journal-title":"Ann Neurol"},{"key":"ref=72","first-page":"567","volume":"54","author":"Antkiewicz-Michaluk L.","year":"2002","unstructured":"Antkiewicz-Michaluk L.; Endogenous risk factors in Parkinson\u2019s disease: Dopamine and tetrahydroisoquinolines. Pol J Pharmacol 2002,54(6),567-572","journal-title":"Pol J Pharmacol"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/jnc.12762","volume":"130","author":"Contu V.R.","year":"2014","unstructured":"Contu V.R.; Kotake Y.; Toyama T.; Okuda K.; Miyara M.; Sakamoto S.; Samizo S.; Sanoh S.; Kumagai Y.; Ohta S.; Endogenous neurotoxic dopamine derivative covalently binds to Parkinson\u2019s disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function. J Neurochem 2014,130(6),826-838","journal-title":"J Neurochem"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1080\/10715760802005177","volume":"42","author":"Zhou Z.","year":"2008","unstructured":"Zhou Z.; Kerk S.; Meng Lim T.; Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132. Free Radic Res 2008,42(5),456-466","journal-title":"Free Radic Res"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3171\/jns.1992.76.1.0053","volume":"76","author":"Laitinen L.V.","year":"1992","unstructured":"Laitinen L.V.; Bergenheim A.T.; Hariz M.I.; Leksell\u2019s posteroventral pallidotomy in the treatment of Parkinson\u2019s disease. J Neurosurg 1992,76(1),53-61","journal-title":"J Neurosurg"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1007\/s00415-018-9100-8","volume":"266","author":"Lim E.W.","year":"2019","unstructured":"Lim E.W.; Aarsland D.; Ffytche D.; Taddei R.N.; van Wamelen D.J.; Wan Y.M.; Tan E.K.; Ray Chaudhuri K.; Kings Parcog group MDS Nonmotor study group. Amyloid-\u03b2 and Parkinson\u2019s disease. J Neurol 2019,266(11),2605-2619","journal-title":"J Neurol"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.neurobiolaging.2004.06.013","volume":"26","author":"Caccamo A.","year":"2005","unstructured":"Caccamo A.; Oddo S.; Sugarman M.C.; Akbari Y.; LaFerla F.M.; Age- and region-dependent alterations in A\u03b2-degrading enzymes: Implications for A\u03b2-induced disorders. Neurobiol Aging 2005,26(5),645-654","journal-title":"Neurobiol Aging"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/alzrt258","volume":"6","author":"Kummer M.P.","year":"2014","unstructured":"Kummer M.P.; Heneka M.T.; Truncated and modified amyloid-beta species. Alzheimers Res Ther 2014,6(3),28","journal-title":"Alzheimers Res Ther"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1212\/WNL.0000000000003840","volume":"88","author":"Rochester L.","year":"2017","unstructured":"Rochester L.; Galna B.; Lord S.; Yarnall A.J.; Morris R.; Duncan G.; Khoo T.K.; Mollenhauer B.; Burn D.J.; Decrease in A\u03b242 predicts dopa-resistant gait progression in early Parkinson disease. Neurology 2017,88(16),1501-1511","journal-title":"Neurology"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000237221","volume":"6","author":"Gmitterov\u00e1 K.","year":"2009","unstructured":"Gmitterov\u00e1 K.; Heinemann U.; Gawinecka J.; Varges D.; Ciesielczyk B.; Valkovic P.; Benetin J.; Zerr I.; 8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases. Neurodegener Dis 2009,6(5-6),263-269","journal-title":"Neurodegener Dis"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neulet.2009.11.065","volume":"469","author":"Isobe C.","year":"2010","unstructured":"Isobe C.; Abe T.; Terayama Y.; Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2\u2032-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson\u2019s disease demonstrate that mitochondrial oxidative damage and\/or oxidative DNA damage contributes to the neurodegenerative process. Neurosci Lett 2010,469(1),159-163","journal-title":"Neurosci Lett"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1089\/ars.2012.5026","volume":"18","author":"Garc\u00eda-Moreno J.M.","year":"2013","unstructured":"Garc\u00eda-Moreno J.M.; Mart\u00edn de Pablos A.; Garc\u00eda-S\u00e1nchez M.I.; M\u00e9ndez-Lucena C.; Damas-Hermoso F.; Rus M.; Chac\u00f3n J.; Fern\u00e1ndez E.; May serum levels of advanced oxidized protein products serve as a prognostic marker of disease duration in patients with idiopathic Parkinson\u2019s disease? Antioxid Redox Signal 2013,18(11),1296-1302","journal-title":"Antioxid Redox Signal"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1006\/nbdi.2002.0466","volume":"9","author":"Kikuchi A.","year":"2002","unstructured":"Kikuchi A.; Takeda A.; Onodera H.; Kimpara T.; Hisanaga K.; Sato N.; Nunomura A.; Castellani R.J.; Perry G.; Smith M.A.; Itoyama Y.; Systemic increase of oxidative nucleic acid damage in Parkinson\u2019s disease and multiple system atrophy. Neurobiol Dis 2002,9(2),244-248","journal-title":"Neurobiol Dis"},{"key":"ref=84","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.trac.2007.12.004","volume":"27","author":"Shiping S.","year":"2008","unstructured":"Shiping S.; Wang L.; Li J.; Fan C.; Zhao Z.; Aptamer-based biosensors, TrAC. Trends Analyt Chem 2008,27(2),108-117","journal-title":"Trends Analyt Chem"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/S1872-2040(10)60451-3","volume":"39","author":"Yuan T.","year":"2011","unstructured":"Yuan T.; Liu Z.Y.; Hu L.Z.; Xu G.B.; Electrochemical and electrochemiluminescent aptasensors. Chin J Anal Chem 2011,39(7),972-977","journal-title":"Chin J Anal Chem"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"122169","DOI":"10.1016\/j.talanta.2021.122169","volume":"226","author":"Melinte G.","year":"2021","unstructured":"Melinte G.; Selvolini G.; Cristea C.; Marrazza G.; Aptasensors for lysozyme detection: Recent advances. Talanta 2021,226,122169","journal-title":"Talanta"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.1002\/anie.200604524","volume":"46","author":"Willner I.","year":"2007","unstructured":"Willner I.; Zayats M.; Electronic aptamer-based sensors. Angew Chem Int Ed 2007,46(34),6408-6418","journal-title":"Angew Chem Int Ed"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"12663","DOI":"10.1021\/acsami.5b03381","volume":"7","author":"Wu D.","year":"2015","unstructured":"Wu D.; Xin X.; Pang X.; Pietraszkiewicz M.; Hozyst R.; Sun X.; Wei Q.; Application of europium multiwalled carbon nanotubes as novel luminophores in an electrochemiluminescent aptasensor for thrombin using multiple amplification strategies. ACS Appl Mater Interfaces 2015,7(23),12663-12670","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1039\/c4an00132j","volume":"139","author":"Zhou W.","year":"2014","unstructured":"Zhou W.; Jimmy Huang P-J.; Ding J.; Liu J.; Aptamer-based biosensors for biomedical diagnostics. Analyst (Lond) 2014,139(11),2627-2640","journal-title":"Analyst (Lond)"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0956-5663(00)00071-3","volume":"15","author":"Pividori M.","year":"2000","unstructured":"Pividori M.; Merko\u00e7i A.; Alegret S.; Electrochemical genosensor design: Immobilisation of oligonucleotides onto transducer surfaces and detection methods. Biosens Bioelectron 2000,15(5-6),291-303","journal-title":"Biosens Bioelectron"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"16823","DOI":"10.1021\/acsomega.8b01996","volume":"3","author":"Mazaafrianto D.N.","year":"2018","unstructured":"Mazaafrianto D.N.; Ishida A.; Maeki M.; Tani H.; Tokeshi M.; Label-free electrochemical sensor for ochratoxin a using a microfabricated electrode with immobilized aptamer. ACS Omega 2018,3(12),16823-16830","journal-title":"ACS Omega"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"34350","DOI":"10.1038\/srep34350","volume":"6","author":"Zamay G.S.","year":"2016","unstructured":"Zamay G.S.; Zamay T.N.; Kolovskii V.A.; Shabanov A.V.; Glazyrin Y.E.; Veprintsev D.V.; Krat A.V.; Zamay S.S.; Kolovskaya O.S.; Gargaun A.; Sokolov A.E.; Modestov A.A.; Artyukhov I.P.; Chesnokov N.V.; Petrova M.M.; Berezovski M.V.; Zamay A.S.; Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples. Sci Rep 2016,6(1),34350","journal-title":"Sci Rep"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1021\/acssensors.6b00581","volume":"2","author":"Ding S.","year":"2017","unstructured":"Ding S.; Mosher C.; Lee X.Y.; Das S.R.; Cargill A.A.; Tang X.; Chen B.; McLamore E.S.; Gomes C.; Hostetter J.M.; Claussen J.C.; Rapid and label-free detection of interferon gamma via an electrochemical aptasensor comprising a ternary surface monolayer on a gold interdigitated electrode array. ACS Sens 2017,2(2),210-217","journal-title":"ACS Sens"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"11906","DOI":"10.1021\/ja053094r","volume":"127","author":"So H.M.","year":"2005","unstructured":"So H.M.; Won K.; Kim Y.H.; Kim B.K.; Ryu B.H.; Na P.S.; Kim H.; Lee J.O.; Single-walled carbon nanotube biosensors using aptamers as molecular recognition elements. J Am Chem Soc 2005,127(34),11906-11907","journal-title":"J Am Chem Soc"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jelechem.2015.10.040","volume":"759","author":"Shi S.S.","year":"2015","unstructured":"Shi S.S.; Jia L.P.; Ma R.N.; Jia W.L.; Wang H.S.; A label-free electrochemical aptasensor for 8-hydroxy-2\u2032-deoxyguanosine detection. J Electroanal Chem (Lausanne) 2015,759,107-112","journal-title":"J Electroanal Chem (Lausanne)"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00449-009-0371-4","volume":"33","author":"Kim Y.J.","year":"2010","unstructured":"Kim Y.J.; Kim Y.S.; Niazi J.H.; Gu M.B.; Electrochemical aptasensor for tetracycline detection. Bioprocess Biosyst Eng 2010,33(1),31-37","journal-title":"Bioprocess Biosyst Eng"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.bios.2009.06.001","volume":"25","author":"Peng Y.","year":"2009","unstructured":"Peng Y.; Zhang D.; Li Y.; Qi H.; Gao Q.; Zhang C.; Label-free and sensitive faradic impedance aptasensor for the determination of lysozyme based on target-induced aptamer displacement. Biosens Bioelectron 2009,25(1),94-99","journal-title":"Biosens Bioelectron"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/S1872-2040(10)60429-X","volume":"39","author":"Zhou L.","year":"2011","unstructured":"Zhou L.; Wang M-H.; Wang J-P.; Ye Z-Z.; Application of biosensor surface immobilization methods for aptamer. Chin J Anal Chem 2011,39(3),432-438","journal-title":"Chin J Anal Chem"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.bios.2015.07.017","volume":"74","author":"Sharma R.","year":"2015","unstructured":"Sharma R.; Ragavan K.V.; Thakur M.S.; Raghavarao K.S.M.S.; Recent advances in nanoparticle based aptasensors for food contaminants. Biosens Bioelectron 2015,74(74),612-627","journal-title":"Biosens Bioelectron"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/elan.201800620","volume":"31","author":"Terti\u015f M.","year":"2019","unstructured":"Terti\u015f M.; Melinte G.; Ciui B.; \u015eimon I.; \u015etiufiuc R.; S\u0103ndulescu R.; Cristea C.; A novel label free electrochemical magnetoimmunosensor for human interleukin-6 quantification in serum. Electroanalysis 2019,31(2),282-292","journal-title":"Electroanalysis"},{"key":"ref=101","first-page":"465","volume":"36","author":"Sang S.","year":"2016","unstructured":"Sang S.; Wang Y.; Feng Q.; Wei Y.; Ji J.; Zhang W.; Progress of new label-free techniques for biosensors: A review. Crit Rev Biotechnol 2016,36(3),465-481","journal-title":"Crit Rev Biotechnol"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2020.03.017","volume":"1111","author":"Cheng L.","year":"2020","unstructured":"Cheng L.; Xu C.; Cui H.; Liao F.; Hong N.; Ma G.; Xiong J.; Fan H.; A sensitive homogenous aptasensor based on tetraferrocene labeling for thrombin detection. Anal Chim Acta 2020,1111,1-7","journal-title":"Anal Chim Acta"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1002\/elan.200804554","volume":"21","author":"Sassolas A.","year":"2009","unstructured":"Sassolas A.; Blum L.J.; Leca-Bouvier B.D.; Electrochemical Aptasensors. Electroanalysis 2009,21(11),1237-1250","journal-title":"Electroanalysis"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00604-021-04704-5","volume":"188","author":"Wang X.","year":"2021","unstructured":"Wang X.; Li L.; Gu X.; Yu B.; Jiang M.; Switchable electrochemical aptasensor for amyloid-\u03b2 oligomers detection based on triple helix switch coupling with AuNPs@CuMOF labeled signaling displaced-probe. Mikrochim Acta 2021,188(2),49","journal-title":"Mikrochim Acta"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"8397","DOI":"10.1021\/ac401810t","volume":"85","author":"Wu L.","year":"2013","unstructured":"Wu L.; Zhang X.; Liu W.; Xiong E.; Chen J.; Sensitive electrochemical aptasensor by coupling \u201csignal-on\u201d and \u201csignal-off\u201d strategies. Anal Chem 2013,85(17),8397-8402","journal-title":"Anal Chem"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13036-017-0054-7","volume":"11","author":"Seo H.B.","year":"2017","unstructured":"Seo H.B.; Gu M.B.; Aptamer-based sandwich-type biosensors. J Biol Eng 2017,11(1),11","journal-title":"J Biol Eng"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3390\/diagnostics11010104","volume":"11","author":"Radi A-E.","year":"2021","unstructured":"Radi A-E.; Abd-Ellatief M.R.; Electrochemical aptasensors: Current status and future perspectives. Diagnostics (Basel) 2021,11(1),104","journal-title":"Diagnostics (Basel)"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.3390\/s100504541","volume":"10","author":"Han K.","year":"2010","unstructured":"Han K.; Liang Z.; Zhou N.; Design strategies for aptamer-based biosensors. Sensors (Basel) 2010,10(5),4541-4557","journal-title":"Sensors (Basel)"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"122068","DOI":"10.1016\/j.talanta.2020.122068","volume":"225","author":"Maugi R.","year":"2021","unstructured":"Maugi R.; Gamble B.; Bunka D.; Platt M.; A simple displacement aptamer assay on resistive pulse sensor for small molecule detection. Talanta 2021,225,122068","journal-title":"Talanta"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.3390\/s19245435","volume":"19","author":"Li Z.","year":"2019","unstructured":"Li Z.; Mohamed M.A.; Vinu Mohan A.M.; Zhu Z.; Sharma V.; Mishra G.K.; Mishra R.K.; Application of electrochemical aptasensors toward clinical diagnostics, food, and environmental monitoring: Review. Sensors (Basel) 2019,19(24),5435","journal-title":"Sensors (Basel)"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s10800-021-01589-3","volume":"51","author":"Tao D.","year":"2021","unstructured":"Tao D.; Wang J.; Song S.; Cai K.; Jiang M.; Cheng J.; Hu L.; Jaffrezic-Renault N.; Guo Z.; Pan H.; Polythionine and gold nanostar-based impedimetric aptasensor for label-free detection of \u03b1-synuclein oligomers. J Appl Electrochem 2021,51(11),1523-1533","journal-title":"J Appl Electrochem"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3390\/nano10050832","volume":"10","author":"Jang S.J.","year":"2020","unstructured":"Jang S.J.; Lee C.S.; Kim T.H.; \u03b1-synuclein oligomer detection with aptamer switch on reduced graphene oxide electrode. Nanomaterials (Basel) 2020,10(5),832","journal-title":"Nanomaterials (Basel)"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/6526850","volume":"2019","author":"You X.","year":"2019","unstructured":"You X.; Gopinath S.C.B.; Lakshmipriya T.; Li D.; High-affinity detection of alpha-synuclein by aptamer-gold conjugates on an amine-modified dielectric surface. J Anal Methods Chem 2019,2019,1-8","journal-title":"J Anal Methods Chem"},{"key":"ref=114","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bios.2018.09.081","volume":"123","author":"Taghdisi S.M.","year":"2019","unstructured":"Taghdisi S.M.; Danesh N.M.; Nameghi M.A.; Ramezani M.; Alibolandi M.; Hassanzadeh-Khayat M.; Emrani A.S.; Abnous K.; A novel electrochemical aptasensor based on nontarget-induced high accumulation of methylene blue on the surface of electrode for sensing of \u03b1-synuclein oligomer. Biosens Bioelectron 2019,123,14-18","journal-title":"Biosens Bioelectron"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/bios9030084","volume":"9","author":"Tao D.","year":"2019","unstructured":"Tao D.; Shui B.; Gu Y.; Cheng J.; Zhang W.; Jaffrezic-Renault N.; Song S.; Guo Z.; Development of a label-free electrochemical aptasensor for the detection of Tau381 and its preliminary application in AD and non-AD patients\u2019 sera. Biosensors 2019,9(3),84","journal-title":"Biosensors"},{"key":"ref=116","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1039\/C8AN00527C","volume":"143","author":"Shui B.","year":"2018","unstructured":"Shui B.; Tao D.; Cheng J.; Mei Y.; Jaffrezic-Renault N.; Guo Z.; A novel electrochemical aptamer\u2013antibody sandwich assay for the detection of tau-381 in human serum. Analyst 2018,143(15),3549-3554","journal-title":"Analyst"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1039\/C5AN00480B","volume":"140","author":"\u00c1lvarez-Martos I.","year":"2015","unstructured":"\u00c1lvarez-Martos I.; Campos R.; Ferapontova E.E.; Surface state of the dopamine RNA aptamer affects specific recognition and binding of dopamine by the aptamer-modified electrodes. Analyst 2015,140(12),4089-4096","journal-title":"Analyst"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"16034","DOI":"10.1021\/ja408485m","volume":"135","author":"Li B.R.","year":"2013","unstructured":"Li B.R.; Hsieh Y.J.; Chen Y.X.; Chung Y.T.; Pan C.Y.; Chen Y.T.; An ultrasensitive nanowire-transistor biosensor for detecting dopamine release from living PC12 cells under hypoxic stimulation. J Am Chem Soc 2013,135(43),16034-16037","journal-title":"J Am Chem Soc"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s00604-015-1509-5","volume":"182","author":"Xu Y.","year":"2015","unstructured":"Xu Y.; Hun X.; Liu F.; Wen X.; Luo X.; Aptamer biosensor for dopamine based on a gold electrode modified with carbon nanoparticles and thionine labeled gold nanoparticles as probe. Mikrochim Acta 2015,182(9-10),1797-1802","journal-title":"Mikrochim Acta"},{"key":"ref=120","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1021\/acssensors.9b01630","volume":"4","author":"Zhang Y.","year":"2019","unstructured":"Zhang Y.; Figueroa-Miranda G.; Zafiu C.; Willbold D.; Offenh\u00e4usser A.; Mayer D.; Amperometric aptasensor for amyloid-\u03b2 oligomer detection by optimized stem-loop structures with an adjustable detection range. ACS Sens 2019,4(11),3042-3050","journal-title":"ACS Sens"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"114017","DOI":"10.1016\/j.jelechem.2020.114017","volume":"862","author":"You M.","year":"2020","unstructured":"You M.; Yang S.; An Y.; Zhang F.; He P.; A novel electrochemical biosensor with molecularly imprinted polymers and aptamer-based sandwich assay for determining amyloid-\u03b2 oligomer. J Electroanal Chem 2020,862,114017","journal-title":"J Electroanal Chem"},{"key":"ref=122","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00604-020-4217-8","volume":"187","author":"Deng C.","year":"2020","unstructured":"Deng C.; Liu H.; Si S.; Zhu X.; Tu Q.; Jin Y.; Xiang J.; An electrochemical aptasensor for amyloid-\u03b2 oligomer based on double-stranded DNA as \u201cconductive spring\u201d. Mikrochim Acta 2020,187(4),239","journal-title":"Mikrochim Acta"},{"key":"ref=123","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.talanta.2017.11.036","volume":"179","author":"Jia L.P.","year":"2018","unstructured":"Jia L.P.; Wang L.J.; Ma R.N.; Shang L.; Zhang W.; Xue Q.W.; Wang H.S.; An electrochemical aptasensor for the highly sensitive detection of 8-hydroxy-2\u2032-deoxyguanosine based on the hybridization chain reaction. Talanta 2018,179,414-419","journal-title":"Talanta"},{"key":"ref=124","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1039\/D0AN00233J","volume":"145","author":"Jia L.P.","year":"2020","unstructured":"Jia L.P.; Feng Z.; Zhao R.N.; Ma R.N.; Zhang W.; Shang L.; Jia W.L.; Wang H.S.; Enzyme-free and triple-amplified electrochemical sensing of 8-hydroxy-2\u2032-deoxyguanosine by three kinds of short pDNA-driven catalyzed hairpin assemblies followed by a hybridization chain reaction. Analyst (Lond) 2020,145(10),3605-3611","journal-title":"Analyst (Lond)"},{"key":"ref=125","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1021\/acs.chemmater.9b00719","volume":"31","author":"Han J.T.","year":"2019","unstructured":"Han J.T.; Cho J.Y.; Kim J.H.; Jang J.I.; Kim J.S.; Lee H.J.; Park J.H.; Chae J.S.; Roh K.C.; Lee W.; Hwang J.Y.; Kim H.Y.; Jeong H.J.; Jeong S.Y.; Lee G-W.; Structural recovery of highly oxidized single-walled carbon nanotubes fabricated by kneading and electrochemical applications. Chem Mater 2019,31(9),3468-3475","journal-title":"Chem Mater"},{"key":"ref=126","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.electacta.2019.04.072","volume":"309","author":"Chen Y.","year":"2019","unstructured":"Chen Y.; Zhang X.; Xu C.; Xu H.; The fabrication of asymmetry supercapacitor based on MWCNTs\/MnO2\/PPy composites. Electrochim Acta 2019,309,424-431","journal-title":"Electrochim Acta"},{"key":"ref=127","doi-asserted-by":"publisher","first-page":"111933","DOI":"10.1016\/j.bios.2019.111933","volume":"150","author":"Sharifi S.","year":"2020","unstructured":"Sharifi S.; Vahed S.Z.; Ahmadian E.; Dizaj S.M.; Eftekhari A.; Khalilov R.; Ahmadi M.; Hamidi-Asl E.; Labib M.; Detection of pathogenic bacteria via nanomaterials-modified aptasensors. Biosens Bioelectron 2020,150,111933","journal-title":"Biosens Bioelectron"},{"key":"ref=128","first-page":"115778","volume":"124","author":"Kholafazad Kordasht H.","year":"2019","unstructured":"Kholafazad Kordasht H.; Pazhuhi M.; Pashazadeh-Panahi P.; Hasanzadeh M.; Shadjou N.; Multifunctional aptasensors based on mesoporous silica nanoparticles as an efficient platform for bioanalytical applications: Recent Advances. TrAC 2019,124,115778","journal-title":"TrAC"}],"container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929867329666220520123337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/205078\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929867329666220520123337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T16:07:34Z","timestamp":1691597254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/205078\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":128,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867329666220520123337","relation":{},"ISSN":["0929-8673"],"issn-type":[{"type":"print","value":"0929-8673"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}