{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T13:21:22Z","timestamp":1721136082924},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"21","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2018,10,15]]},"abstract":"<jats:sec>\n<jats:title \/>\n<jats:p>Fats are essential nutrients that have a significant role in the human diet and are essential to provide\nenergy. Fatty acids are present in several types of lipids, such as triglycerides and phospholipids. Fatty acids\ndiffer among them, depending on the number of double bonds and on the length of the hydrocarbon chains. If\nthere are no double bonds, the fatty acids are considered saturated and show a linear structure. Compounds with\ndouble bonds are unsaturated and have bent structure. The saturated fatty acids are usually solid at room temperature\nand the unsaturated fatty acids are liquid at that very same temperature. These compounds are of recognized\nvalue as raw materials for drug delivery systems, such as lipid nanoparticles. The behaviour of the macroscopic\naspects of fat polymorphisms is directly influenced by the melting point, the crystallization and their polymorphic\ntransformations. In this work, we revise the most critical factors contributing for the long-term stability of lipid\nnanoparticles, as well as the influence of the polymorphism on the loading capacity for drug molecules.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612824666180522092740","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T07:31:25Z","timestamp":1527060685000},"page":"2508-2512","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phase Behavior of Polymorphic Fats in Drug Delivery Systems - A Review of the State of Art"],"prefix":"10.2174","volume":"24","author":[{"given":"Joana R.","family":"Campos","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciencias da Saude, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Ana R.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciencias da Saude, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"Biotechnology Industrial Program, Laboratory of Nanotechnology and Nanomedicine (LNMed), University of Tiradentes, Av. Murilo Dantas, 300, 49010-390 Aracaju, Sergipe, Brazil"}]},{"given":"Maria L.","family":"Gracia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy, University of Barcelona, 08028, Barcelona, Spain"}]},{"given":"Selma B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Braga Hospital, Sete Fontes, 4710-243 Sao Victor Braga, Portugal"}]},{"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciencias da Saude, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]}],"member":"965","container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/162326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/162326\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/162326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T19:50:47Z","timestamp":1608925847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/162326\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":0,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2018,10,15]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1381612824666180522092740","relation":{},"ISSN":["1381-6128"],"issn-type":[{"value":"1381-6128","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10,15]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}