{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:40:22Z","timestamp":1761946822678},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"19","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2018,9,24]]},"abstract":"<jats:sec>\n<jats:title \/>\n<jats:p>Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on\nhuman health and notably, on the cardiovascular system. Some of these compounds showed significant protective\nactivities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy,\nangiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation\nof signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels.\nThese effects can be mediated by changes in expression level and by post-translational modifications of proteins\n(e.g. Stat1, CaMKII, Sirtuins, BCL-2 family members, PDEs, TRF2, eNOS and SOD). This non-comprehensive\nshort review aims to summarize recent knowledge on the main pharmacological effects and mechanisms of cardioprotection\nof pure polyphenols, using different approaches such as cell culture, animal models and human\nstudies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612824666180608102344","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T14:49:48Z","timestamp":1537973388000},"page":"2137-2156","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pure Polyphenols Applications for Cardiac Health and Disease"],"prefix":"10.2174","volume":"24","author":[{"given":"Claudia N.","family":"Santos","sequence":"first","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnologica, Apartado 12, 2780-901 Oeiras, Portugal"}]},{"given":"Andreia","family":"Gomes","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnologica, Apartado 12, 2780-901 Oeiras, Portugal"}]},{"given":"Carole","family":"Oudot","sequence":"additional","affiliation":[{"name":"INSERM UMR-S 1180- LabEx LERMIT, Universite Paris-Sud, Universite Paris-Saclay, 5 rue Jean-Baptiste Clement 92296 Chatenay Malabry, France"}]},{"given":"Daniela","family":"Dias-Pedroso","sequence":"additional","affiliation":[{"name":"CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Campo dos Martires da Patria, 130, 1169-056, Lisboa, Portugal"}]},{"given":"Ana","family":"Rodriguez-Mateos","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King`s College London, 150 Stamford Street, SE1 9NH, London, United Kingdom"}]},{"given":"Helena L.A.","family":"Vieira","sequence":"additional","affiliation":[{"name":"CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Campo dos Martires da Patria, 130, 1169-056, Lisboa, Portugal"}]},{"given":"Catherine","family":"Brenner","sequence":"additional","affiliation":[{"name":"INSERM UMR-S 1180- LabEx LERMIT, Universite Paris-Sud, Universite Paris-Saclay, 5 rue Jean-Baptiste Clement 92296 Chatenay Malabry, France"}]}],"member":"965","container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/162928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/162928\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/162928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T19:50:11Z","timestamp":1608925811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/162928\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":0,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2018,9,24]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1381612824666180608102344","relation":{},"ISSN":["1381-6128"],"issn-type":[{"value":"1381-6128","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,24]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}