{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:15:17Z","timestamp":1775020517801,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"29","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2018,12,8]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> The \u03b2-caryophyllene (BCP), a phytocannabinoid present in various essential oils, demonstrated\nselective action on the CB2 endocannabinoid receptor and attracted considerable attention because of its\nseveral pharmacological activities. Despite this recognized potential, this hydrophobic compound is a volatile and\nacid-sensitive sesquiterpene that readily oxidizes when exposed to air, and has low bioavailability in oral formulations.\nThus, the development of formulations that guarantee its stability and increase its bioavailability is a challenge\nfor its use in the pharmaceutical field.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods: <\/jats:title>\n<jats:p>The present review brings for the first time a comprehensive overview of the controlled and vectorized\nrelease formulations tested for BCP administration. Among these, we have addressed nanoemulsions, inclusion\ncomplexes with cyclodextrins, liposomes, wound dressings, nanocomposites and nanoparticles. A literature\nsearch was performed on Pubmed, Web of Science and Science direct, and patents documents were also searched\non European Patent Office, World Intellectual Property Organization and Brazilian National Institute of Industrial\nProperty.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The systems presented here may represent an interesting approach to overcome the limitations already\nmentioned for this terpene. These systems proved to be promising for improving solubility, stability and controlled\nrelease of this pharmacological relevant sesquiterpene. In the industrial field, some companies have filed\npatent applications for the commercial use of the BCP, however, the use of pharmaceutical formulations still\nappeared moderate.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> This prospective study evidenced the new perspectives related to BCP vectorization systems in the\npharmaceutical and industrial marketing field and may serve as a basis for further research and pharmaceutical\nuse of this powerful cannabinoid.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612824666180912151412","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T12:06:28Z","timestamp":1536753988000},"page":"3440-3453","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["\u03b2-caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability"],"prefix":"10.2174","volume":"24","author":[{"given":"Pauline S.","family":"Santos","sequence":"first","affiliation":[{"name":"Postgraduate Program of Northeast Biotechnology Network, Faculty of Pharmacy, Federal University of Piaui, Teresina, Piau\u00ed, Brazil"}]},{"given":"Thaisa C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Pernambuco, Recife, Pernambuco, Brazil"}]},{"given":"Lu\u00eds M\u00e1rio","family":"R. J\u00fanior","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Piaui, Teresina, Piaui, Brazil"}]},{"given":"Ana","family":"Figueiras","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal"}]},{"given":"L\u00edvio C.C.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Piaui, Teresina, Piaui, Brazil"}]}],"member":"965","container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/165376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/165376\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/165376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T19:53:02Z","timestamp":1608925982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/165376\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,8]]},"references-count":0,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2018,12,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1381612824666180912151412","relation":{},"ISSN":["1381-6128"],"issn-type":[{"value":"1381-6128","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}