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In fact, the\nquick development of resistance mechanisms by the microorganisms has been fatal for millions of people around\nthe world, turning into a public health issue. The major cause of the resistance mechanisms is the overuse of\nantimicrobials. European countries try to implement mechanisms to overcome antimicrobial resistance in the\ncommunity through the rational use of antimicrobials. The scientific community has been exhaustively dedicated\nto the discovering of new, safer and efficient drugs, being the exploitation of natural resources, mainly plants and\nfungi, considered as a hot topic in the field of antimicrobial agents. Innumerous reports have already shown the\npromising capacity of natural products or molecules extracted from these natural resources, to act as bacteriostatic\nand bactericidal agents. More importantly, these natural agents present significantly lower harmful effects. Bearing\nthat in mind, this review aims at giving a contribution to the knowledge about the synthetic antibiotics of the\nlast generation. Moreover, it is intended to provide information about the last advances regarding the discovery of\nnew antimicrobial agents. Thus, a compilation of the chemical characteristics, efficiency, harmful outcomes and\nresistance mechanisms developed by the microorganisms can be consulted in the following sections together with\na critical discussion, in line with the recent approaches. Furthermore, modern strategies for the prospection of\nnovel anti-infective compounds for tackling resistant bacteria have been considered as also a current synopsis of\nplants and mushrooms with relevant antimicrobial potentials.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612826666200224105153","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T14:21:24Z","timestamp":1582554084000},"page":"815-837","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Bacterial Resistance: Antibiotics of Last Generation used in Clinical Practice and the Arise of Natural Products as New Therapeutic Alternatives"],"prefix":"10.2174","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5061-7071","authenticated-orcid":true,"given":"R\u00fabia C.G.","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Centro de Investigacao de Montanha (CIMO), Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-1098","authenticated-orcid":true,"given":"Sandrina A.","family":"Heleno","sequence":"additional","affiliation":[{"name":"Centro de Investigacao de Montanha (CIMO), Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8506-4393","authenticated-orcid":true,"given":"Maria J.","family":"Alves","sequence":"additional","affiliation":[{"name":"Centro de Investigacao de Montanha (CIMO), Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":true,"given":"Isabel C.F.R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Investigacao de Montanha (CIMO), Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"25","author":"Radi\u0107 N.","year":"2012","unstructured":"Radi\u0107 N.; Bratkovi\u010d T.; Future antibiotic agents: turning to nature for inspiration. 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