{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:15:01Z","timestamp":1776291301095,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"24","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/DTP\/04567\/2016"],"award-info":[{"award-number":["UID\/DTP\/04567\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/QUI\/50006\/2019"],"award-info":[{"award-number":["UID\/QUI\/50006\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/DTP\/04567\/2019"],"award-info":[{"award-number":["UID\/DTP\/04567\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2020,7,21]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Medicinal plants are a good source of novel therapeutic drugs, due to the phytochemicals present.\nArtemia, commonly known as brine shrimp, is a tiny halophilic invertebrate belonging to class Crustacean, which\nplays an important role in saline aquatic and marine eco-systems. Besides its usage in aquaculture, it is also\nhighly valued for its application in toxicity detection and it is used in areas such as Ecology, Physiology, Ecotoxicology,\nAquaculture and Genetics. Furthermore, Artemia based lethality assay (brine shrimp lethality assay,\nBSLA) is rapid, convenient and low cost. Presently, brine shrimp lethality assays are enormously employed in\nresearch and applied toxicology. It has been used in the study of natural products as a preliminary toxicity assay\nto screen a large number of extracts and compounds for drug discovery in medicinal plants. The aim of this review\npaper is to collect, organize, select and discuss the existing knowledge about the different uses of Artemia\nsalina as a bench-top bioassay for the discovery and purification of bioactive natural products.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612826666200406083035","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T14:09:01Z","timestamp":1586182141000},"page":"2892-2908","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Artemia species: An Important Tool to Screen General Toxicity Samples"],"prefix":"10.2174","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-8985","authenticated-orcid":true,"given":"Epole","family":"Ntungwe N","sequence":"first","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-4292","authenticated-orcid":true,"given":"Eva M.","family":"Dom\u00ednguez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6224-7135","authenticated-orcid":true,"given":"Amilcar","family":"Roberto","sequence":"additional","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3360-1190","authenticated-orcid":true,"given":"Joana","family":"Tavares","sequence":"additional","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-7287","authenticated-orcid":true,"given":"Vera M. S.","family":"Isca","sequence":"additional","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-6812","authenticated-orcid":true,"given":"Paula","family":"Pereira","sequence":"additional","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"given":"Maria-Jo\u00e3o","family":"Cebola","sequence":"additional","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-8343","authenticated-orcid":true,"given":"Patr\u00edcia","family":"Rijo","sequence":"additional","affiliation":[{"name":"CBIOS - Center for Research in Biosciences & Health Technologies, Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisbon, Portugal"}]}],"member":"965","container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/180718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T08:25:54Z","timestamp":1600590354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/180718\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":0,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,7,21]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1381612826666200406083035","relation":{},"ISSN":["1381-6128"],"issn-type":[{"value":"1381-6128","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}