{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:33:29Z","timestamp":1777404809361,"version":"3.51.4"},"reference-count":95,"publisher":"Bentham Science Publishers Ltd.","issue":"8","funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation (FCT\/MCT) and European Funds","doi-asserted-by":"publisher","award":["UIDB\/04469\/2020"],"award-info":[{"award-number":["UIDB\/04469\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation (FCT\/MCT) and European Funds","doi-asserted-by":"publisher","award":["UID\/AGR\/04033\/2019"],"award-info":[{"award-number":["UID\/AGR\/04033\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre within the MINIATURA 4","doi-asserted-by":"publisher","award":["2020\/04\/X\/ST5\/00789"],"award-info":[{"award-number":["2020\/04\/X\/ST5\/00789"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>Hydrogels for the modified-release drug delivery systems are a continuously growing area of interest\nfor the pharmaceutical industry. According to the global market, the profit resulting from the use of polymers in\nthis area is projected to reach $31.4 million by 2027. This review discusses the recent advances in and perspectives\nof hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic delivery. The\nsearch was conducted, in January 2021, in an extensive database to identify studies published from January\n2010 to December 2020. We described the main characteristic of the polymers to obtain an ideal hydrogel for a\nspecific route of administration and the formulations. It was concluded that the hydrogels are useful to decrease\nthe number of doses and side effects, promote adhesion of patient, and enhance the bioavailability of the drugs,\nthus improving the safety and efficacy of the treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612828666211230114755","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T12:07:48Z","timestamp":1640866068000},"page":"609-618","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Hydrogels for Modified-release Drug Delivery Systems"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-1377","authenticated-orcid":true,"given":"Aleksandra","family":"Zieli\u0144ska","sequence":"first","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Strzeszy\u0144ska 32, 60-479 Pozna\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-5038","authenticated-orcid":true,"given":"Piotr","family":"Eder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,\nDietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Pozna\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-2030","authenticated-orcid":true,"given":"Lucas","family":"Rannier","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research and University of Tiradentes, Aracaju, Sergipe, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-4144","authenticated-orcid":true,"given":"Juliana C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research and University of Tiradentes, Aracaju, Sergipe, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":true,"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research and University of Tiradentes, Aracaju, Sergipe, Brazil | Tiradentes Institute, 150 Mt Vernon St, Dorchester, MA 02125, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-9914","authenticated-orcid":true,"given":"Am\u00e9lia M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biology and Environment, School of Life Sciences and Environment, University of\nTr\u00e1s-os-Montes and Alto Douro (UTAD), 5001-801 Vila Real, Portugal | Centre for Research and Technology of Agro-\nEnvironmental and Biological Sciences (CITAB), UTAD, 5001-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":true,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"EB - Centre of Biological Engineering,\nUniversity of Minho, Campus de Gualtar 4710-057 Braga, Portugal | LABBELS - Associate Laboratory, Braga, Guimar\u00e3es,\nPortugal"}]}],"member":"965","reference":[{"key":"ref=1","unstructured":"Global Opportunity Analysis and Industry Forecast 2020\u20132027, 2020. Available from:"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"E603","DOI":"10.3390\/molecules24030603","volume":"24","author":"Narayanaswamy R.","year":"2019","unstructured":"Narayanaswamy R.; Torchilin V.P.; Hydrogels and their applications in targeted drug delivery. Molecules 2019,24(3),E603","journal-title":"Molecules"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"8092","DOI":"10.1038\/s41598-018-26432-2","volume":"8","author":"Su C.Y.","year":"2018","unstructured":"Su C.Y.; Ho H.O.; Chen Y.C.; Complex hydrogels composed of chitosan with ring-opened polyvinyl pyrrolidone as a gastroretentive drug dosage form to enhance the bioavailability of bisphosphonates. Sci Rep 2018,8(1),8092","journal-title":"Sci Rep"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"5415","DOI":"10.1039\/D0BM01004A","volume":"8","author":"Zhu Y.","year":"2020","unstructured":"Zhu Y.; Wang L.; Li Y.; Injectable pH and redox dual responsive hydrogels based on self-assembled peptides for anti-tumor drug delivery. Biomater Sci 2020,8(19),5415-5426","journal-title":"Biomater Sci"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s13346-017-0468-2","volume":"8","author":"Radwan R.R.","year":"2018","unstructured":"Radwan R.R.; Mohamed H.A.; Ali H.E.; Mahmoud G.A.; Radiation preparation of L-arginine\/acrylic acid hydrogel matrix patch for transdermal delivery of propranolol HCl in hypertensive rats. Drug Deliv Transl Res 2018,8(3),525-535","journal-title":"Drug Deliv Transl Res"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1093\/jbcr\/irz113","volume":"40","author":"Grolman J.M.","year":"2019","unstructured":"Grolman J.M.; Singh M.; Mooney D.J.; Eriksson E.; Nuutila K.; Antibiotic-containing agarose hydrogel for wound and burn care. J Burn Care Res 2019,40(6),900-906","journal-title":"J Burn Care Res"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1096\/fj.201901603RR","volume":"34","author":"Zhang S.S.","year":"2020","unstructured":"Zhang S.S.; Xu X.X.; Xiang W.W.; Using 17\u03b2-estradiol heparin-poloxamer thermosensitive hydrogel to enhance the endometrial regeneration and functional recovery of intrauterine adhesions in a rat model. FASEB J 2020,34(1),446-457","journal-title":"FASEB J"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1590\/S1516-93322005000200003","volume":"41","author":"Lopes C.M.","year":"2005","unstructured":"Lopes C.M.; Lobo J.M.S.; Costa P.; Modified release of drug delivery systems: hydrophilic polymers. Revista Brasileira de Ci\u00eancias Farmac\u00eauticas 2005,41(2),143-154","journal-title":"Revista Brasileira de Ci\u00eancias Farmac\u00eauticas"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1590\/S0100-40422010000400044","volume":"33","author":"Louren\u00e7o A.L.","year":"2010","unstructured":"Louren\u00e7o A.L.; Lira L.M.; Carvalho D.P.; Melo P.A.; Cl\u00e1udio-da-Silva T.S.; Carvalho DPd, Melo PdA, Cl\u00e1udio-da-Silva TS. Gest\u00e3o das inova\u00e7\u00f5es incrementais, o caso omeprazola. Quim Nova 2010,33(4),1000-1004","journal-title":"Quim Nova"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nrd1610","volume":"4","author":"Cohen F.J.","year":"2005","unstructured":"Cohen F.J.; Macro trends in pharmaceutical innovation. Nat Rev Drug Discov 2005,4(1),78-84","journal-title":"Nat Rev Drug Discov"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","volume":"1","author":"Li J.","year":"2016","unstructured":"Li J.; Mooney D.J.; Designing hydrogels for controlled drug delivery. Nat Rev Mater 2016,1(12),16071","journal-title":"Nat Rev Mater"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/185117a0","volume":"185","author":"Wichterle O.","year":"1960","unstructured":"Wichterle O.; Lim D.; Hydrophilic gels for biological use. Nature 1960,185(4706),117-118","journal-title":"Nature"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.2174\/0929867326666191122144916","volume":"27","author":"Jiang Y.","year":"2020","unstructured":"Jiang Y.; Wang Y.; Li Q.; Yu C.; Chu W.; Natural polymer-based stimuli-responsive hydrogels. Curr Med Chem 2020,27(16),2631-2657","journal-title":"Curr Med Chem"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0939-6411(00)00090-4","volume":"50","author":"Peppas N.A.","year":"2000","unstructured":"Peppas N.A.; Bures P.; Leobandung W.; Ichikawa H.; Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 2000,50(1),27-46","journal-title":"Eur J Pharm Biopharm"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"E2173","DOI":"10.3390\/polym12102173","volume":"12","author":"Batista R.A.","year":"2020","unstructured":"Batista R.A.; Espitia P.J.P.; Vergne D.M.C.; Development and evaluation of superabsorbent hydrogels based on natural polymers. Polymers (Basel) 2020,12(10),E2173","journal-title":"Polymers (Basel)"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.3390\/polym13081187","volume":"13","author":"Yoshida C.M.P.","year":"2021","unstructured":"Yoshida C.M.P.; Pacheco M.S.; de Moraes M.A.; Effect of chitosan and aloe vera extract concentrations on the physicochemical properties of chitosan biofilms. Polymers (Basel) 2021,13(8),1187","journal-title":"Polymers (Basel)"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijbiomac.2020.12.035","volume":"168","author":"Chatterjee S.","year":"2021","unstructured":"Chatterjee S.; Hui P.C.; Siu W.S.; Influence of pH-responsive compounds synthesized from chitosan and hyaluronic acid on dual-responsive (pH\/temperature) hydrogel drug delivery systems of Cortex Moutan. Int J Biol Macromol 2021,168,163-174","journal-title":"Int J Biol Macromol"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1080\/09205063.2020.1866350","volume":"32","author":"Yan M.","year":"2021","unstructured":"Yan M.; Chen T.; Zhang S.; Lu T.; Sun X.; A core-shell structured alginate hydrogel beads with tunable thickness of carboxymethyl cellulose coating for pH responsive drug delivery. J Biomater Sci Polym Ed 2021,32(6),763-778","journal-title":"J Biomater Sci Polym Ed"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"11658","DOI":"10.1038\/s41598-019-48254-6","volume":"9","author":"Chatterjee S.","year":"2019","unstructured":"Chatterjee S.; Hui P.C.; Kan C.W.; Wang W.; Dual-responsive (pH\/temperature) Pluronic F-127 hydrogel drug delivery system for textile-based transdermal therapy. Sci Rep 2019,9(1),11658","journal-title":"Sci Rep"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ijpharm.2012.10.049","volume":"441","author":"Jose S.","year":"2013","unstructured":"Jose S.; Ansa C.R.; Cinu T.A.; Thermo-sensitive gels containing lorazepam microspheres for intranasal brain targeting. Int J Pharm 2013,441(1-2),516-526","journal-title":"Int J Pharm"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"111555","DOI":"10.1016\/j.msec.2020.111555","volume":"119","author":"Deng A.","year":"2021","unstructured":"Deng A.; Yang Y.; Du S.; Preparation of a recombinant collagen-peptide (RHC)-conjugated chitosan thermosensitive hydrogel for wound healing. Mater Sci Eng C 2021,119,111555","journal-title":"Mater Sci Eng C"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"2011; pp. 3-24","DOI":"10.1533\/9780857091383.1.3","author":"Holback H.","year":"1 - Hydrogel swelling behavior and its\nbiomedical applications. In: Rimmer S, Ed. Biomedical Hydrogels.\nWoodhead Publishing","unstructured":"Holback H.; Yeo Y.; Park K.;  1 - Hydrogel swelling behavior and its\nbiomedical applications. In: Rimmer S, Ed. Biomedical Hydrogels.\nWoodhead Publishing,2011; pp. 3-24"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2174\/1567201817666200129130031","volume":"17","author":"Cassano R.","year":"2020","unstructured":"Cassano R.; Curcio F.; Mandracchia D.; Trapani A.; Trombino S.; Gelatin and glycerine-based bioadhesive vaginal hydrogel. Curr Drug Deliv 2020,17(4),303-311","journal-title":"Curr Drug Deliv"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1080\/10837450.2019.1686524","volume":"25","author":"Qi X-J.","year":"2020","unstructured":"Qi X-J.; Liu X-Y.; Tang L-M-Y.; Li P-F.; Qiu F.; Yang A-H.; Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery. Pharm Dev Technol 2020,25(3),316-325","journal-title":"Pharm Dev Technol"},{"key":"ref=25","first-page":"1045","volume":"28","author":"Severino P.","year":"2014","unstructured":"Severino P.; Da Silva C.F.; Dalla Costa T.C.; In vivo absorption of didanosine formulated in pellets composed of chitosan microspheres. In Vivo 2014,28(6),1045-1050","journal-title":"In Vivo"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"300ra128","DOI":"10.1126\/scitranslmed.aaa5657","volume":"7","author":"Zhang S.","year":"2015","unstructured":"Zhang S.; Ermann J.; Succi M.D.; An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease. Sci Transl Med 2015,7(300),300ra128","journal-title":"Sci Transl Med"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"E47","DOI":"10.3390\/gels5040047","volume":"5","author":"Patlolla V.G.R.","year":"2019","unstructured":"Patlolla V.G.R.; Peter Holbrook W.; Gizurarson S.; Kristmundsdottir T.; Doxycycline and monocaprin in situ hydrogel: Effect on stability, mucoadhesion and texture analysis and in vitro release. Gels 2019,5(4),E47","journal-title":"Gels"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0168-3659(99)00233-3","volume":"65","author":"Huang Y.","year":"2000","unstructured":"Huang Y.; Leobandung W.; Foss A.; Peppas N.A.; Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces. J Control Release 2000,65(1-2),63-71","journal-title":"J Control Release"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s10792-018-0955-6","volume":"39","author":"Deepthi S.","year":"2019","unstructured":"Deepthi S.; Jose J.; Novel hydrogel-based ocular drug delivery system for the treatment of conjunctivitis. Int Ophthalmol 2019,39(6),1355-1366","journal-title":"Int Ophthalmol"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.ijbiomac.2020.11.214","volume":"167","author":"Bao Z.","year":"2021","unstructured":"Bao Z.; Yu A.; Shi H.; Glycol chitosan\/oxidized hyaluronic acid hydrogel film for topical ocular delivery of dexamethasone and levofloxacin. Int J Biol Macromol 2021,167,659-666","journal-title":"Int J Biol Macromol"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"111445","DOI":"10.1016\/j.msec.2020.111445","volume":"119","author":"Wen Y.","year":"2021","unstructured":"Wen Y.; Jia H.; Mo Z.; Cross-linked thermosensitive nanohydrogels for ocular drug delivery with a prolonged residence time and enhanced bioavailability. Mater Sci Eng C 2021,119,111445","journal-title":"Mater Sci Eng C"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"110941","DOI":"10.1016\/j.biopha.2020.110941","volume":"133","author":"Yang Y.","year":"2021","unstructured":"Yang Y.; Chen S.; Liu Y.; Long-term treatment of polysaccharides-based hydrogel microparticles as oral insulin delivery in streptozotocin-induced type 2 diabetic mice. Biomed Pharmacother 2021,133,110941","journal-title":"Biomed Pharmacother"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1089\/adt.2020.1021","volume":"19","author":"Durai R.D.","year":"2021","unstructured":"Durai R.D.; Nallakkannu J.; Rajaraman K.; Bodethala Narayanan V.H.; Dual drug loaded bilayer hydrogel coated with citric acid for the treatment of dry mouth syndrome. Assay Drug Dev Technol 2021,19(2),139-152","journal-title":"Assay Drug Dev Technol"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/j.jsps.2020.10.016","volume":"28","author":"El-Masry S.M.","year":"2020","unstructured":"El-Masry S.M.; Helmy S.A.; Hydrogel-based matrices for controlled drug delivery of etamsylate: Prediction of in-vivo plasma profiles. Saudi Pharm J 2020,28(12),1704-1718","journal-title":"Saudi Pharm J"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ijpharm.2019.04.047","volume":"564","author":"Gon\u00e7alves J.","year":"2019","unstructured":"Gon\u00e7alves J.; Bicker J.; Gouveia F.; Nose-to-brain delivery of levetiracetam after intranasal administration to mice. Int J Pharm 2019,564,329-339","journal-title":"Int J Pharm"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1208\/s12249-019-1517-6","volume":"20","author":"Gholizadeh H.","year":"2019","unstructured":"Gholizadeh H.; Messerotti E.; Pozzoli M.; Application of a thermosensitive in situ gel of chitosan-based nasal spray loaded with tranexamic acid for localised treatment of nasal wounds. AAPS PharmSciTech 2019,20(7),299","journal-title":"AAPS PharmSciTech"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"105783","DOI":"10.1016\/j.ejps.2021.105783","volume":"161","author":"Zhang S.","year":"2021","unstructured":"Zhang S.; Liu C.; Yang D.; Mechanism insight on drug skin delivery from polyurethane hydrogels: Roles of molecular mobility and intermolecular interaction. Eur J Pharm Sci 2021,161,105783","journal-title":"Eur J Pharm Sci"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"119626","DOI":"10.1016\/j.ijpharm.2020.119626","volume":"587","author":"Xu H.","year":"2020","unstructured":"Xu H.; Wen Y.; Chen S.; Zhu L.; Feng R.; Song Z.; Paclitaxel skin delivery by micelles-embedded Carbopol 940 hydrogel for local therapy of melanoma. Int J Pharm 2020,587,119626","journal-title":"Int J Pharm"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.actbio.2020.06.006","volume":"112","author":"Johnson K.A.","year":"2020","unstructured":"Johnson K.A.; Muzzin N.; Toufanian S.; Drug-impregnated, pressurized gas expanded liquid-processed alginate hydrogel scaffolds for accelerated burn wound healing. Acta Biomater 2020,112,101-111","journal-title":"Acta Biomater"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.3390\/nano11102758","volume":"11","author":"Fernandes A.R.","year":"2021","unstructured":"Fernandes A.R.; Sanchez-Lopez E.; Santini A.; Mono- and dicationic DABCO\/Quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization. Nanomaterials (Basel) 2021,11(10),2758","journal-title":"Nanomaterials (Basel)"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"7541","DOI":"10.3390\/ma14247541","volume":"14","author":"Fernandes A.R.","year":"2021","unstructured":"Fernandes A.R.; Sanchez-Lopez E.; Santos T.D.; Garcia M.L.; Silva A.M.; Souto E.B.; Development and characterization of nanoemulsions for ophthalmic applications: Role of cationic surfactants. Materials (Basel) 2021,14(24),7541","journal-title":"Materials (Basel)"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/pharmaceutics13101652","volume":"13","author":"Fernandes A.R.","year":"2021","unstructured":"Fernandes A.R.; Santos T.D.; Granja P.L.; DABCO-customized nanoemulsions: Characterization, cell viability and genotoxicity in retinal pigmented epithelium and microglia cells. Pharmaceutics 2021,13(10),1652","journal-title":"Pharmaceutics"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/jps.22784","volume":"101","author":"Gonzalez-Mira E.","year":"2012","unstructured":"Gonzalez-Mira E.; Nikoli\u0107 S.; Calpena A.C.; Egea M.A.; Souto E.B.; Garc\u00eda M.L.; Improved and safe transcorneal delivery of flurbiprofen by NLC and NLC-based hydrogels. J Pharm Sci 2012,101(2),707-725","journal-title":"J Pharm Sci"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.ijbiomac.2019.10.193","volume":"152","author":"Noreen S.","year":"2020","unstructured":"Noreen S.; Ghumman S.A.; Batool F.; Terminalia arjuna gum\/alginate in situ gel system with prolonged retention time for ophthalmic drug delivery. Int J Biol Macromol 2020,152,1056-1067","journal-title":"Int J Biol Macromol"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.carbpol.2016.08.073","volume":"155","author":"Yu S.","year":"2017","unstructured":"Yu S.; Zhang X.; Tan G.; A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery. Carbohydr Polym 2017,155,208-217","journal-title":"Carbohydr Polym"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"109799","DOI":"10.1016\/j.msec.2019.109799","volume":"103","author":"Cocarta A-I.","year":"2019","unstructured":"Cocarta A-I.; Hobzova R.; Sirc J.; Hydrogel implants for transscleral drug delivery for retinoblastoma treatment. Mater Sci Eng C 2019,103,109799","journal-title":"Mater Sci Eng C"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"e2000118","DOI":"10.1002\/adhm.202000118","volume":"9","author":"Kim D.I.","year":"2020","unstructured":"Kim D.I.; Lee H.; Kwon S.H.; Sung Y.J.; Song W.K.; Park S.; Bilayer hydrogel sheet-type intraocular microrobot for drug delivery and magnetic nanoparticles retrieval. Adv Healthc Mater 2020,9(13),e2000118","journal-title":"Adv Healthc Mater"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.pharmthera.2012.03.003","volume":"134","author":"Grassin-Delyle S.","year":"2012","unstructured":"Grassin-Delyle S.; Buenestado A.; Naline E.; Intranasal drug delivery: an efficient and non-invasive route for systemic administration: focus on opioids. Pharmacol Ther 2012,134(3),366-379","journal-title":"Pharmacol Ther"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1080\/17425247.2019.1597051","volume":"16","author":"Gholizadeh H.","year":"2019","unstructured":"Gholizadeh H.; Cheng S.; Pozzoli M.; Smart thermosensitive chitosan hydrogel for nasal delivery of ibuprofen to treat neurological disorders. Expert Opin Drug Deliv 2019,16(4),453-466","journal-title":"Expert Opin Drug Deliv"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"2021; pp. 93-114","DOI":"10.1016\/B978-0-12-822522-6.00006-0","author":"Pardeshi C.V.","year":"Chapter 6 - Surface modification of\nnanocarriers as a strategy to enhance the direct nose-to-brain drug\ndelivery. In: Pardeshi CV, Souto EB, Eds. Direct Nose-to-Brain\nDrug Delivery. Academic Press","unstructured":"Pardeshi C.V.; Souto E.B.;  Chapter 6 - Surface modification of\nnanocarriers as a strategy to enhance the direct nose-to-brain drug\ndelivery. In: Pardeshi CV, Souto EB, Eds. Direct Nose-to-Brain\nDrug Delivery. Academic Press,2021; pp. 93-114"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3390\/pharmaceutics13050686","volume":"13","author":"Barros C.","year":"2021","unstructured":"Barros C.; Aranha N.; Severino P.; Quality by design approach for the development of liposome carrying ghrelin for intranasal administration. Pharmaceutics 2021,13(5),686","journal-title":"Pharmaceutics"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ijpharm.2016.01.071","volume":"501","author":"Abrego G.","year":"2016","unstructured":"Abrego G.; Alvarado H.; Souto E.B.; Biopharmaceutical profile of hydrogels containing pranoprofen-loaded PLGA nanoparticles for skin administration: In vitro, ex vivo and in vivo characterization. Int J Pharm 2016,501(1-2),350-361","journal-title":"Int J Pharm"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejpb.2004.02.015","volume":"58","author":"Souto E.B.","year":"2004","unstructured":"Souto E.B.; Wissing S.A.; Barbosa C.M.; M\u00fcller R.H.; Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. Eur J Pharm Biopharm 2004,58(1),83-90","journal-title":"Eur J Pharm Biopharm"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"9563","DOI":"10.1038\/s41598-019-46032-y","volume":"9","author":"Al Harthi S.","year":"2019","unstructured":"Al Harthi S.; Alavi S.E.; Radwan M.A.; El Khatib M.M.; AlSarra I.A.; Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer\u2019s disease. Sci Rep 2019,9(1),9563","journal-title":"Sci Rep"},{"key":"ref=55","author":"Adnet T","year":"2020 12(3): 251","unstructured":"Adnet T; Groo A-C; Picard C; Davis A; Corvaisier S; Since M;  Pharmacotechnical development of a nasal drug delivery composite nanosystem intended for Alzheimer\u2019s disease treatment 2020 12(3): 251","journal-title":"Pharmacotechnical development of a nasal drug delivery composite nanosystem intended for Alzheimer\u2019s disease treatment"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.carbpol.2014.09.094","volume":"117","author":"Zhou H.Y.","year":"2015","unstructured":"Zhou H.Y.; Jiang L.J.; Cao P.P.; Li J.B.; Chen X.G.; Glycerophosphate-based chitosan thermosensitive hydrogels and their biomedical applications. Carbohydr Polym 2015,117,524-536","journal-title":"Carbohydr Polym"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.ijbiomac.2020.06.087","volume":"162","author":"Bozo\u011flan B.K.","year":"2020","unstructured":"Bozo\u011flan B.K.; Duman O.; Tun\u00e7 S.; Preparation and characterization of thermosensitive chitosan\/carboxymethylcellulose\/scleroglucan nanocomposite hydrogels. Int J Biol Macromol 2020,162,781-797","journal-title":"Int J Biol Macromol"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"E2514","DOI":"10.3390\/polym12112514","volume":"12","author":"Panyamao P.","year":"2020","unstructured":"Panyamao P.; Ruksiriwanich W.; Sirisa-Ard P.; Charumanee S.; Injectable thermosensitive chitosan\/pullulan-based hydrogels with improved mechanical properties and swelling capacity. Polymers (Basel) 2020,12(11),E2514","journal-title":"Polymers (Basel)"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.ijbiomac.2017.04.106","volume":"102","author":"Tentor F.R.","year":"2017","unstructured":"Tentor F.R.; de Oliveira J.H.; Scariot D.B.; Scaffolds based on chitosan\/pectin thermosensitive hydrogels containing gold nanoparticles. Int J Biol Macromol 2017,102,1186-1194","journal-title":"Int J Biol Macromol"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"21015","DOI":"10.1021\/acsomega.0c02580","volume":"5","author":"Yang M.","year":"2020","unstructured":"Yang M.; He S.; Su Z.; Yang Z.; Liang X.; Wu Y.; Thermosensitive injectable chitosan\/collagen\/\u03b2-glycerophosphate composite hydrogels for enhancing wound healing by encapsulating mesenchymal stem cell spheroids. ACS Omega 2020,5(33),21015-21023","journal-title":"ACS Omega"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.ijpharm.2014.05.043","volume":"471","author":"Sattar M.","year":"2014","unstructured":"Sattar M.; Sayed O.M.; Lane M.E.; Oral transmucosal drug delivery--current status and future prospects. Int J Pharm 2014,471(1-2),498-506","journal-title":"Int J Pharm"},{"key":"ref=62","first-page":"287","author":"Marto J.","year":"2020","unstructured":"Marto J.; Ribeiro H.; Almeida A.;  Starch-based nanocapsules as drug carriers for topical drug delivery Smart Nanocontainers 2020,287-294","journal-title":"Starch-based nanocapsules as drug carriers for topical drug delivery Smart Nanocontainers"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3109\/03639045.2013.828219","volume":"40","author":"Rehman K.","year":"2014","unstructured":"Rehman K.; Zulfakar M.H.; Recent advances in gel technologies for topical and transdermal drug delivery. Drug Dev Ind Pharm 2014,40(4),433-440","journal-title":"Drug Dev Ind Pharm"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3389\/fphar.2019.01057","volume":"10","author":"Feitosa R.C.","year":"2019","unstructured":"Feitosa R.C.; Geraldes D.C.; Beraldo-de-Ara\u00fajo V.L.; Costa J.S.R.; Oliveira-Nascimento L.; Pharmacokinetic aspects of nanoparticle-in-matrix drug delivery systems for oral\/buccal delivery. Front Pharmacol 2019,10,1057","journal-title":"Front Pharmacol"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"105125","DOI":"10.1016\/j.ejps.2019.105125","volume":"142","author":"Pagano C.","year":"2020","unstructured":"Pagano C.; Giovagnoli S.; Perioli L.; Tiralti M.C.; Ricci M.; Development and characterization of mucoadhesive-thermoresponsive gels for the treatment of oral mucosa diseases. Eur J Pharm Sci 2020,142,105125","journal-title":"Eur J Pharm Sci"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"862","DOI":"10.2174\/1567201816666191014102531","volume":"16","author":"Mamdouh M.","year":"2019","unstructured":"Mamdouh M.; Donia A.; Essa E.; Maghraby G.E.; Preparation of liquid oral mucoadhesive gastro-retentive system of nimodipine. Curr Drug Deliv 2019,16(9),862-871","journal-title":"Curr Drug Deliv"},{"key":"ref=67","year":"EMA. EMA\/CHMP\/EWP\/280\/96, Guideline on the pharmacokinetic\nand clinical evaluation of modified release dosage forms,\nCommittee for Medicinal Products for Human Use (CHMP), 20th\nNovember 2014. 2014","unstructured":"EMA. EMA\/CHMP\/EWP\/280\/96, Guideline on the pharmacokinetic\nand clinical evaluation of modified release dosage forms,\nCommittee for Medicinal Products for Human Use (CHMP), 20th\nNovember 2014. 2014"},{"key":"ref=68","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbab008","author":"Cheng Z","year":"2021; 8(2): rbab008","unstructured":"Cheng Z; Qing R; Hao S;  Fabrication of ulcer-adhesive oral\nkeratin hydrogel for gastric ulcer healing in a rat Regen Biomater 2021; 8(2): rbab008","journal-title":"Fabrication of ulcer-adhesive oral\nkeratin hydrogel for gastric ulcer healing in a rat Regen Biomater"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.msec.2015.11.034","volume":"60","author":"Barbosa G.P.","year":"2016","unstructured":"Barbosa G.P.; Debone H.S.; Severino P.; Souto E.B.; da Silva C.F.; Design and characterization of chitosan\/zeolite composite films--Effect of zeolite type and zeolite dose on the film properties. Mater Sci Eng C 2016,60,246-254","journal-title":"Mater Sci Eng C"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s10856-013-5088-x","volume":"25","author":"Maeng J.H.","year":"2014","unstructured":"Maeng J.H.; Bang B.W.; Lee E.; Endoscopic application of EGF-chitosan hydrogel for precipitated healing of GI peptic ulcers and mucosectomy-induced ulcers. J Mater Sci Mater Med 2014,25(2),573-582","journal-title":"J Mater Sci Mater Med"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41467-017-00144-z","volume":"8","author":"Liu J.","year":"2017","unstructured":"Liu J.; Pang Y.; Zhang S.; Triggerable tough hydrogels for gastric resident dosage forms. Nat Commun 2017,8(1),124","journal-title":"Nat Commun"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"13155","DOI":"10.1038\/srep13155","volume":"5","author":"Yoon Y.M.","year":"2015","unstructured":"Yoon Y.M.; Lewis J.S.; Carstens M.R.; A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice. Sci Rep 2015,5(1),13155","journal-title":"Sci Rep"},{"key":"ref=73","author":"Dias-Ferreira J.","year":"Chapter 13 - Skin rejuvenation: Biopolymers applied to UV sunscreens and sheet masks. In: de Moraes MA, da Silva CF, Vieira RS, Eds. Biopolymer Membranes and Films. Elsevier 2020; pp. 309-30","unstructured":"Dias-Ferreira J.; Fernandes A.R.; Soriano J.L.; Naveros B.C.; Severino P.; da Silva C.F.;  Chapter 13 - Skin rejuvenation: Biopolymers applied to UV sunscreens and sheet masks. In: de Moraes MA, da Silva CF, Vieira RS, Eds. Biopolymer Membranes and Films. Elsevier 2020; pp. 309-30"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/10837450.2021.1898634","volume":"26","author":"de Oliveira D.M.","year":"2021","unstructured":"de Oliveira D.M.; Menezes D.B.; Andrade L.R.; Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability, and in vitro efficacy. Pharm Dev Technol 2021,26(5),539-548","journal-title":"Pharm Dev Technol"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.carbpol.2016.03.072","volume":"147","author":"Goh M.","year":"2016","unstructured":"Goh M.; Hwang Y.; Tae G.; Epidermal growth factor loaded heparin-based hydrogel sheet for skin wound healing. Carbohydr Polym 2016,147,251-260","journal-title":"Carbohydr Polym"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"110923","DOI":"10.1016\/j.msec.2020.110923","volume":"112","author":"Hsu F.M.","year":"2020","unstructured":"Hsu F.M.; Hu M.H.; Jiang Y.S.; Lin B.Y.; Hu J.J.; Jan J.S.; Antibacterial polypeptide\/heparin composite hydrogels carrying growth factor for wound healing. Mater Sci Eng C 2020,112,110923","journal-title":"Mater Sci Eng C"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"5813","DOI":"10.1080\/14786419.2020.1821019","volume":"35","author":"Yeung A.W.K.","year":"2021","unstructured":"Yeung A.W.K.; Tzvetkov N.T.; Durazzo A.; Natural products in diabetes research: quantitative literature analysis. Nat Prod Res 2021,35(24),5813-5827","journal-title":"Nat Prod Res"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"E336","DOI":"10.3390\/medicina56070336","volume":"56","author":"Zieli\u0144ska A.","year":"2020","unstructured":"Zieli\u0144ska A.; Alves H.; Marques V.; Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects. Medicina (Kaunas) 2020,56(7),E336","journal-title":"Medicina (Kaunas)"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.colsurfb.2010.07.020","volume":"81","author":"Nayak A.P.","year":"2010","unstructured":"Nayak A.P.; Tiyaboonchai W.; Patankar S.; Madhusudhan B.; Souto E.B.; Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment. Colloids Surf B Biointerfaces 2010,81(1),263-273","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"E2286","DOI":"10.3390\/polym12102286","volume":"12","author":"Alven S.","year":"2020","unstructured":"Alven S.; Nqoro X.; Aderibigbe B.A.; Polymer-based materials loaded with curcumin for wound healing applications. Polymers (Basel) 2020,12(10),E2286","journal-title":"Polymers (Basel)"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"6377","DOI":"10.1016\/j.biomaterials.2013.05.005","volume":"34","author":"Gong C.","year":"2013","unstructured":"Gong C.; Wu Q.; Wang Y.; A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 2013,34(27),6377-6387","journal-title":"Biomaterials"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1080\/17518253.2020.1725149","volume":"13","author":"Zakia M.","year":"2020","unstructured":"Zakia M.; Koo J.M.; Kim D.; Development of silver nanoparticle-based hydrogel composites for antimicrobial activity. Green Chem Lett Rev 2020,13(1),34-40","journal-title":"Green Chem Lett Rev"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3390\/nano10020390","volume":"10","author":"Diniz F.R.","year":"2020","unstructured":"Diniz F.R.; Maia R.C.A.P.; Rannier L.; Silver nanoparticles-composing alginate\/gelatin hydrogel improves wound healing in vivo. Nanomaterials (Basel) 2020,10(2),390","journal-title":"Nanomaterials (Basel)"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"E535","DOI":"10.3390\/pharmaceutics11100535","volume":"11","author":"Hissae Yassue-Cordeiro P.","year":"2019","unstructured":"Hissae Yassue-Cordeiro P.; Zandonai C.H.; Pereira Genesi B.; Development of chitosan\/silver sulfadiazine\/zeolite composite films for wound dressing. Pharmaceutics 2019,11(10),E535","journal-title":"Pharmaceutics"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jsps.2019.11.008","volume":"28","author":"Bektas N.","year":"2020","unstructured":"Bektas N.; \u015eenel B.; Yenilmez E.; \u00d6zatik O.; Arslan R.; Evaluation of wound healing effect of chitosan-based gel formulation containing vitexin. Saudi Pharm J 2020,28(1),87-94","journal-title":"Saudi Pharm J"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"E1305","DOI":"10.3390\/ijms20061305","volume":"20","author":"Salehi B.","year":"2019","unstructured":"Salehi B.; Venditti A.; Sharifi-Rad M.; The therapeutic potential of apigenin. Int J Mol Sci 2019,20(6),E1305","journal-title":"Int J Mol Sci"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.jsps.2019.09.006","volume":"27","author":"Vel\u00e1zquez N.S.","year":"2019","unstructured":"Vel\u00e1zquez N.S.; Turino L.N.; Luna J.A.; Mengatto L.N.; Progesterone loaded thermosensitive hydrogel for vaginal application: Formulation and in vitro comparison with commercial product. Saudi Pharm J 2019,27(8),1096-1106","journal-title":"Saudi Pharm J"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1016\/j.jconrel.2015.05.123","volume":"213","author":"Almomen A.A.","year":"2015","unstructured":"Almomen A.A.; Cho S.; Li Z.; Huh K.M.; Matthew Peterson C.; Jan\u00e1t-Amsbury M.M.; A thermosensitive glycol chitin hydrogel for the vaginal delivery of progesterone. J Control Release 2015,213,e74-e75","journal-title":"J Control Release"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"e0186268","DOI":"10.1371\/journal.pone.0186268","volume":"12","author":"Good M.M.","year":"2017","unstructured":"Good M.M.; Montoya T.I.; Shi H.; Thermosensitive hydrogels deliver bioactive protein to the vaginal wall. PLoS One 2017,12(10),e0186268","journal-title":"PLoS One"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"3564060","DOI":"10.1155\/2017\/3564060","volume":"2017","author":"Yang T-T.","year":"2017","unstructured":"Yang T-T.; Cheng Y-Z.; Qin M.; Thermosensitive chitosan hydrogels containing polymeric microspheres for vaginal drug delivery. BioMed Res Int 2017,2017,3564060","journal-title":"BioMed Res Int"},{"key":"ref=91","first-page":"116","volume":"22","author":"Wang H.","year":"2016","unstructured":"Wang H.; Han X.; Wittchen E.S.; Hartnett M.E.; TNF-\u03b1 mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent \u03b2-catenin activation. Mol Vis 2016,22,116-128","journal-title":"Mol Vis"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"E15","DOI":"10.3390\/pharmaceutics11010015","volume":"11","author":"Ci L.Q.","year":"2019","unstructured":"Ci L.Q.; Huang Z.G.; Lv F.M.; Enhanced delivery of imatinib into vaginal mucosa via a new positively charged nanocrystal-loaded in situ hydrogel formulation for treatment of cervical cancer. Pharmaceutics 2019,11(1),E15","journal-title":"Pharmaceutics"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ejpb.2016.11.024","volume":"112","author":"Malli S.","year":"2017","unstructured":"Malli S.; Bories C.; Pradines B.; Loiseau P.M.; Ponchel G.; Bouchemal K.; In situ forming pluronic\u00ae F127\/chitosan hydrogel limits metronidazole transmucosal absorption. Eur J Pharm Biopharm 2017,112,143-147","journal-title":"Eur J Pharm Biopharm"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41427-018-0103-9","volume":"11","author":"Chen H.","year":"2019","unstructured":"Chen H.; Cheng R.; Zhao X.; An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair. NPG Asia Mater 2019,11(1),3","journal-title":"NPG Asia Mater"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"e10158","DOI":"10.1002\/btm2.10158","volume":"5","author":"Mandal A.","year":"2020","unstructured":"Mandal A.; Clegg J.R.; Anselmo A.C.; Mitragotri S.; Hydrogels in the clinic. Bioeng Transl Med 2020,5(2),e10158","journal-title":"Bioeng Transl Med"}],"container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1381612828666211230114755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/199670\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1381612828666211230114755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T08:00:29Z","timestamp":1657008029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/199670\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":95,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1381612828666211230114755","relation":{},"ISSN":["1381-6128"],"issn-type":[{"value":"1381-6128","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2021-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}