{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:27:57Z","timestamp":1759825677734,"version":"3.37.3"},"reference-count":162,"publisher":"Bentham Science Publishers Ltd.","issue":"11","funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT, Portugal) through national funds FCT\/MCTES","doi-asserted-by":"publisher","award":["UIDB\/00690\/2020","UIDP\/00690\/2020","CEECIND\/03040\/2017"],"award-info":[{"award-number":["UIDB\/00690\/2020","UIDP\/00690\/2020","CEECIND\/03040\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SusTEC","award":["LA\/P\/0007\/2021"],"award-info":[{"award-number":["LA\/P\/0007\/2021"]}]},{"DOI":"10.13039\/501100008530","name":"AquaValor-Centro de Valoriza\u00e7\u00e3o e Transfer\u00eancia de Tecnologia da \u00c1gua by Norte Portugal Regional Operational Programme (NORTE 2020) through European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0246-FEDER-000053"],"award-info":[{"award-number":["NORTE-01-0246-FEDER-000053"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>Infectious diseases have always been a concern for human health, responsible for numerous pandemics\nthroughout history. Even with the advancement of medicine, new infectious diseases have been discovered\nover the years, requiring constant effort in medical research to avoid future problems. Like the emergence of\nnew diseases, the increase in resistance of certain bacterial strains also becomes a concern, carried out through\nthe misuse of antibiotics, generating the adaptation of certain microorganisms. Worldwide, the resistance developed\nby several bacterial strains is growing exponentially, creating awareness and developing novel strategies\nto control their evolution a mandatory research topic. Methicillin-resistant Staphylococcus aureus (MRSA)\nis an example of a bacterial strain that causes serious and mortal infections. The fact is that this bacterial strain\nstarted to develop resistance against commonly used antibiotics, first to penicillin and against methicillin. Thus,\nthe treatment against infections caused by MRSA is limited and difficult due to its capacity to develop defense\nmechanisms against the antibiotic's action. Given the urgency to find new alternatives, the scientific community\nhas been developing interesting research regarding the exploitation of natural resources to discover bioactive\nmolecules that are able to inhibit\/kill MRSA. In this sense, several natural matrices, namely plants, have shown\ngreat potential against MRSA, due to the presence of phenolic compounds, molecules with high antimicrobial\ncapacity due to their chemical structure and arrangement.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612829666230410095155","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T04:24:15Z","timestamp":1681187055000},"page":"837-851","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Emerging Strategies to Combat Methicillin-resistant Staphylococcus aureus\n(MRSA): Natural Agents with High Potential"],"prefix":"10.2174","volume":"29","author":[{"given":"Jonata M.","family":"Ueda","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253,\nPortugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico\nde Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253, Portugal"}]},{"given":"Catarina","family":"Milho","sequence":"additional","affiliation":[{"name":"AquaValor - Centro de Valoriza\u00e7\u00e3o e Transfer\u00eancia de\nTecnologia da \u00c1gua-Associa\u00e7\u00e3o, Rua Dr. J\u00falio Martins n.\u00ba 1, Chaves, 5400-342, Portugal"}]},{"given":"Sandrina","family":"A. Heleno","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253,\nPortugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico\nde Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253, Portugal"}]},{"given":"Anton","family":"Soria-Lopez","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group,\nDepartment of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo-Ourense Campus,\nOurense, E-320044, Spain"}]},{"given":"Maria","family":"Carpena","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group,\nDepartment of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo-Ourense Campus,\nOurense, E-320044, Spain"}]},{"given":"Maria J.","family":"Alves","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253,\nPortugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico\nde Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253, Portugal"},{"name":"AquaValor - Centro de Valoriza\u00e7\u00e3o e Transfer\u00eancia de\nTecnologia da \u00c1gua-Associa\u00e7\u00e3o, Rua Dr. J\u00falio Martins n.\u00ba 1, Chaves, 5400-342, Portugal"}]},{"given":"T\u00e2nia","family":"Pires","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253,\nPortugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico\nde Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253, Portugal"}]},{"given":"Miguel A.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group,\nDepartment of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo-Ourense Campus,\nOurense, E-320044, Spain"}]},{"given":"Jesus","family":"Simal-Gandara","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group,\nDepartment of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo-Ourense Campus,\nOurense, E-320044, Spain"}]},{"given":"Ricardo","family":"C. Calhelha","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253,\nPortugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico\nde Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253, Portugal"}]},{"given":"Isabel C.F.R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253,\nPortugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico\nde Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253, Portugal"}]},{"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253,\nPortugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico\nde Bragan\u00e7a, Campus de Santa Apol\u00f3nia, Bragan\u00e7a, 5300-253, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","volume":"115","author":"Klein E.Y.","year":"2018","unstructured":"Klein E.Y.; Van Boeckel T.P.; Martinez E.M.; Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci 2018,115(15),E3463-E3470","journal-title":"Proc Natl Acad Sci"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1473-3099(20)30332-7","volume":"21","author":"Klein E.Y.","year":"2021","unstructured":"Klein E.Y.; Milkowska-Shibata M.; Tseng K.K.; Assessment of WHO antibiotic consumption and access targets in 76 countries, 2000-15: An analysis of pharmaceutical sales data. Lancet Infect Dis 2021,21(1),107-115","journal-title":"Lancet Infect Dis"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.mib.2019.10.008","volume":"51","author":"Hutchings M.I.","year":"2019","unstructured":"Hutchings M.I.; Truman A.W.; Wilkinson B.; Antibiotics: Past, present and future. Curr Opin Microbiol 2019,51,72-80","journal-title":"Curr Opin Microbiol"},{"key":"ref=4","first-page":"57","volume":"22","author":"P\u00e9rez R.M.D.","year":"1998","unstructured":"P\u00e9rez R.M.D.; Bacterial resistance to antimicrobials: Its importance\nin decision-making in daily practice. Therapeutic Information of the National Health System 1998,22(3),57-67","journal-title":"Therapeutic Information of the National Health System"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.addr.2005.04.002","volume":"57","author":"Wright G.","year":"2005","unstructured":"Wright G.; Bacterial resistance to antibiotics: Enzymatic degradation and modification. Adv Drug Deliv Rev 2005,57(10),1451-1470","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nature10388","volume":"477","author":"D\u2019Costa V.M.","year":"2011","unstructured":"D\u2019Costa V.M.; King C.E.; Kalan L.; Antibiotic resistance is ancient. Nature 2011,477(7365),457-461","journal-title":"Nature"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"e0069533","DOI":"10.1371\/journal.pone.0069533","volume":"10","author":"Perron G.G.","year":"2015","unstructured":"Perron G.G.; Whyte L.; Turnbaugh P.J.; Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics. PLoS One 2015,10(3),e0069533","journal-title":"PLoS One"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3389\/fmicb.2016.00173","volume":"7","author":"von Wintersdorff C.J.H.","year":"2016","unstructured":"von Wintersdorff C.J.H.; Penders J.; van Niekerk J.M.; Dissemination of antimicrobial resistance in microbial ecosystems through horizontal gene transfer. Front Microbiol 2016,7,173","journal-title":"Front Microbiol"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0140-6736(77)91941-9","volume":"309","author":"Sabath L.D.","year":"1977","unstructured":"Sabath L.D.; Laverdiere M.; Wheeler N.; Blazevic D.; Wilkinson B.; A new type of penicillin resistance of Staphylococcus aureus. Lancet 1977,309(8009),443-447","journal-title":"Lancet"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"516","DOI":"10.7164\/antibiotics.53.516","volume":"53","author":"Nakamura A.","year":"2000","unstructured":"Nakamura A.; Nakazawa K.; Miyakozawa I.; Macrolide esterase-producing Escherichia coli clinically isolated in Japan. J Antibiot 2000,53(5),516-524","journal-title":"J Antibiot"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.7164\/antibiotics.37.1692","volume":"37","author":"Barth\u00e9l\u00e9my P.","year":"1984","unstructured":"Barth\u00e9l\u00e9my P.; Autissier D.; Gerbaud G.; Courvalin P.; Enzymic hydrolysis of erythomycin by a strain of Escherichia coli. J Antibiot 1984,37(12),1692-1696","journal-title":"J Antibiot"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1128\/AAC.40.4.992","volume":"40","author":"Wondrack L.","year":"1996","unstructured":"Wondrack L.; Massa M.; Yang B.V.; Sutcliffe J.; Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides. Antimicrob Agents Chemother 1996,40(4),992-998","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"15730","DOI":"10.1021\/ja039307z","volume":"125","author":"Fillgrove K.L.","year":"2003","unstructured":"Fillgrove K.L.; Pakhomova S.; Newcomer M.E.; Armstrong R.N.; Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. J Am Chem Soc 2003,125(51),15730-15731","journal-title":"J Am Chem Soc"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nsb830","volume":"9","author":"Vetting M.W.","year":"2002","unstructured":"Vetting M.W.; Hegde S.S.; Javid-Majd F.; Blanchard J.S.; Roderick S.L.; Aminoglycoside 2\u2032-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nat Struct Biol 2002,9(9),653-658","journal-title":"Nat Struct Biol"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0092-8674(00)81585-8","volume":"94","author":"Wolf E.","year":"1998","unstructured":"Wolf E.; Vassilev A.; Makino Y.; Sali A.; Nakatani Y.; Burley S.K.; Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase. Cell 1998,94(4),439-449","journal-title":"Cell"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"6689","DOI":"10.1021\/bi980106v","volume":"37","author":"Beaman T.W.","year":"1998","unstructured":"Beaman T.W.; Sugantino M.; Roderick S.L.; Structure of the hexapeptide xenobiotic acetyltransferase from Pseudomonas aeruginosa. Biochemistry 1998,37(19),6689-6696","journal-title":"Biochemistry"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1128\/AAC.43.7.1813","volume":"43","author":"Werner G.","year":"1999","unstructured":"Werner G.; Witte W.; Characterization of a new enterococcal gene, satG, encoding a putative acetyltransferase conferring resistance to Streptogramin A compounds. Antimicrob Agents Chemother 1999,43(7),1813-1814","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"6936","DOI":"10.1021\/bi00188a024","volume":"33","author":"McKay G.A.","year":"1994","unstructured":"McKay G.A.; Thompson P.R.; Wright G.D.; Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: Overexpression, purification, and substrate specificity. Biochemistry 1994,33(22),6936-6944","journal-title":"Biochemistry"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0378-1119(83)90022-7","volume":"23","author":"Trieu-Cuot P.","year":"1983","unstructured":"Trieu-Cuot P.; Courvalin P.; Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3\u20185\u2019'-aminoglycoside phosphotransferase type III. Gene 1983,23(3),331-341","journal-title":"Gene"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0378-1097(92)90369-Y","volume":"97","author":"Kono M.","year":"1992","unstructured":"Kono M.; O\u2019Hara K.; Ebisu T.; Purification and characterization of macrolide 2\u2032-phosphotransferase type II from a strain of Escherichia coli highly resistant to macrolide antibiotics. FEMS Microbiol Lett 1992,97(1-2),89-94","journal-title":"FEMS Microbiol Lett"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"11977","DOI":"10.1021\/bi00096a006","volume":"32","author":"Sakon J.","year":"1993","unstructured":"Sakon J.; Liao H.H.; Kanikula A.M.; Benning M.M.; Rayment I.; Holden H.M.; Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-.ANG. resolution. Biochemistry 1993,32(45),11977-11984","journal-title":"Biochemistry"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0378-1119(86)90213-1","volume":"43","author":"Brisson-No\u00ebl A.","year":"1986","unstructured":"Brisson-No\u00ebl A.; Courvalin P.; Nucleotide sequence of gene linA encoding resistance to lincosamides in Staphylococcus haemolyticus. Gene 1986,43(3),247-253","journal-title":"Gene"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1128\/AAC.31.12.1887","volume":"31","author":"Leclercq R.","year":"1987","unstructured":"Leclercq R.; Brisson-No\u00ebl A.; Duval J.; Courvalin P.; Phenotypic expression and genetic heterogeneity of lincosamide inactivation in Staphylococcus spp. Antimicrob Agents Chemother 1987,31(12),1887-1891","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1128\/AAC.43.4.925","volume":"43","author":"Bozdogan B.","year":"1999","unstructured":"Bozdogan B.; Berrezouga L.; Kuo M.S.; A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025. Antimicrob Agents Chemother 1999,43(4),925-929","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1128\/AAC.41.11.2456","volume":"41","author":"Quan S.","year":"1997","unstructured":"Quan S.; Venter H.; Dabbs E.R.; Ribosylative inactivation of rifampin by Mycobacterium smegmatis is a principal contributor to its low susceptibility to this antibiotic. Antimicrob Agents Chemother 1997,41(11),2456-2460","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1128\/AAC.36.2.348","volume":"36","author":"Cundliffe E.","year":"1992","unstructured":"Cundliffe E.; Glycosylation of macrolide antibiotics in extracts of Streptomyces lividans. Antimicrob Agents Chemother 1992,36(2),348-352","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"e02272","DOI":"10.1128\/mBio.02272-14","volume":"6","author":"Jenkins A.","year":"2015","unstructured":"Jenkins A.; Diep B.A.; Mai T.T.; Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease. MBio 2015,6(1),e02272-e14","journal-title":"MBio"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"11001","DOI":"10.1021\/ja026879v","volume":"124","author":"Rife C.L.","year":"2002","unstructured":"Rife C.L.; Pharris R.E.; Newcomer M.E.; Armstrong R.N.; Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+). J Am Chem Soc 2002,124(37),11001-11003","journal-title":"J Am Chem Soc"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1128\/JB.183.7.2380-2383.2001","volume":"183","author":"Cao M.","year":"2001","unstructured":"Cao M.; Bernat B.A.; Wang Z.; Armstrong R.N.; Helmann J.D.; FosB, a cysteine-dependent fosfomycin resistance protein under the control of \u03c3(W), an extracytoplasmic-function \u03c3 factor in Bacillus subtilis. J Bacteriol 2001,183(7),2380-2383","journal-title":"J Bacteriol"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"52346","DOI":"10.1074\/jbc.M409573200","volume":"279","author":"Yang W.","year":"2004","unstructured":"Yang W.; Moore I.F.; Koteva K.P.; Bareich D.C.; Hughes D.W.; Wright G.D.; TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. J Biol Chem 2004,279(50),52346-52352","journal-title":"J Biol Chem"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1128\/AAC.40.3.595","volume":"40","author":"Lee C.K.","year":"1996","unstructured":"Lee C.K.; Minami M.; Sakuda S.; Nihira T.; Yamada Y.; Stereospecific reduction of virginiamycin M1 as the virginiamycin resistance pathway in Streptomyces virginiae. Antimicrob Agents Chemother 1996,40(3),595-601","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"8877","DOI":"10.1021\/bi0106787","volume":"40","author":"Mukhtar T.A.","year":"2001","unstructured":"Mukhtar T.A.; Koteva K.P.; Hughes D.W.; Wright G.D.; Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. Biochemistry 2001,40(30),8877-8886","journal-title":"Biochemistry"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MMBR.00035-13","volume":"78","author":"Darmon E.","year":"2014","unstructured":"Darmon E.; Leach D.R.F.; Bacterial genome instability. Microbiol Mol Biol Rev 2014,78(1),1-39","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/molbev\/mss221","volume":"30","author":"Guglielmini J.","year":"2013","unstructured":"Guglielmini J.; de la Cruz F.; Rocha E.P.C.; Evolution of conjugation and type IV secretion systems. Mol Biol Evol 2013,30(2),315-331","journal-title":"Mol Biol Evol"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plasmid.2015.01.001","volume":"79","author":"Brown-Jaque M.","year":"2015","unstructured":"Brown-Jaque M.; Calero-C\u00e1ceres W.; Muniesa M.; Transfer of antibiotic-resistance genes via phage-related mobile elements. Plasmid 2015,79,1-7","journal-title":"Plasmid"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrmicro3199","volume":"12","author":"Johnston C.","year":"2014","unstructured":"Johnston C.; Martin B.; Fichant G.; Polard P.; Claverys J.P.; Bacterial transformation: Distribution, shared mechanisms and divergent control. Nat Rev Microbiol 2014,12(3),181-196","journal-title":"Nat Rev Microbiol"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.3389\/fmicb.2018.01441","volume":"9","author":"Baptista P.V.","year":"2018","unstructured":"Baptista P.V.; McCusker M.P.; Carvalho A.; Nano-strategies to fight multidrug resistant bacteria-\u201cA Battle of the Titans\u201d. Front Microbiol 2018,9,1441","journal-title":"Front Microbiol"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"6600","DOI":"10.1002\/anie.201506818","volume":"55","author":"Chellat M.F.","year":"2016","unstructured":"Chellat M.F.; Ragu\u017e L.; Riedl R.; Targeting antibiotic resistance. Angew Chem Int Ed 2016,55(23),6600-6626","journal-title":"Angew Chem Int Ed"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3390\/antibiotics9100642","volume":"9","author":"Silva A.","year":"2020","unstructured":"Silva A.; Silva S.A.; Carpena M.; Macroalgae as a source of valuable antimicrobial compounds: Extraction and applications. Antibiotics 2020,9(10),642","journal-title":"Antibiotics"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.drudis.2020.10.011","volume":"26","author":"Vanamala K.","year":"2021","unstructured":"Vanamala K.; Tatiparti K.; Bhise K.; Novel approaches for the treatment of methicillin-resistant Staphylococcus aureus: Using nanoparticles to overcome multidrug resistance. Drug Discov Today 2021,26(1),31-43","journal-title":"Drug Discov Today"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1128\/AAC.39.6.1211","volume":"39","author":"Bush K.","year":"1995","unstructured":"Bush K.; Jacoby G.A.; Medeiros A.A.; A functional classification scheme for \u03b2-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother 1995,39(6),1211-1233","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"330","DOI":"10.4067\/S0716-10182004000400007","volume":"21","author":"Mella M.S.","year":"2004","unstructured":"Mella M.S.; Sep\u00falveda A.M.; Gonz\u00e1lez R.G.; Aminogluc\u00f3sidos-aminociclitoles: Caracter\u00edsticas estructurales y nuevos aspectos sobre su resistencia. Rev Chilena Infectol 2004,21(4),330-338","journal-title":"Rev Chilena Infectol"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/978-981-15-2724-1_13","author":"Aldeyab M.","year":"2020","unstructured":"Aldeyab M.; L\u00f3pez-Lozano J.M.; Gould I.M.; Global antibiotics use and resistance. Global Pharmaceutical Policy 2020,331-344","journal-title":"Global Pharmaceutical Policy"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"e001315","DOI":"10.1136\/bmjgh-2018-001315","volume":"4","author":"Klein E.Y.","year":"2019","unstructured":"Klein E.Y.; Tseng K.K.; Pant S.; Laxminarayan R.; Tracking global trends in the effectiveness of antibiotic therapy using the Drug Resistance Index. BMJ Glob Health 2019,4(2),e001315","journal-title":"BMJ Glob Health"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.drudis.2018.11.015","volume":"24","author":"Dougan G.","year":"2019","unstructured":"Dougan G.; Dowson C.; Overington J.; Meeting the discovery challenge of drug-resistant infections: progress and focusing resources. Drug Discov Today 2019,24(2),452-461","journal-title":"Drug Discov Today"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"128865","DOI":"10.1016\/j.jclepro.2021.128865","volume":"320","author":"Herraiz-Carbon\u00e9 M.","year":"2021","unstructured":"Herraiz-Carbon\u00e9 M.; Cotillas S.; Lacasa E.; Are we correctly targeting the research on disinfection of antibiotic-resistant bacteria (ARB)? J Clean Prod 2021,320,128865","journal-title":"J Clean Prod"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.drup.2016.06.002","volume":"27","author":"Hwang I.Y.","year":"2016","unstructured":"Hwang I.Y.; Koh E.; Kim H.R.; Yew W.S.; Chang M.W.; Reprogrammable microbial cell-based therapeutics against antibiotic-resistant bacteria. Drug Resist Updat 2016,27,59-71","journal-title":"Drug Resist Updat"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/82_2016_32","volume":"409","author":"Olaniyi R.","year":"2016","unstructured":"Olaniyi R.; Pozzi C.; Grimaldi L.; Bagnoli F.; Staphylococcus aureus-associated skin and soft tissue infections: Anatomical localization, epidemiology, therapy and potential prophylaxis. Curr Top Microbiol Immunol 2016,409,199-227","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MD.0b013e318194da65","volume":"88","author":"Fern\u00e1ndez Guerrero M.L.","year":"2009","unstructured":"Fern\u00e1ndez Guerrero M.L.; Gonz\u00e1lez L\u00f3pez J.J.; Goyenechea A.; Fraile J.; de G\u00f3rgolas M.; Endocarditis caused by Staphylococcus aureus: A reappraisal of the epidemiologic, clinical, and pathologic manifestations with analysis of factors determining outcome. Medicine 2009,88(1),1-22","journal-title":"Medicine"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1001\/jama.2014.9743","volume":"312","author":"Holland T.L.","year":"2014","unstructured":"Holland T.L.; Arnold C.; Fowler V.G.; Clinical management of Staphylococcus aureus bacteremia: A review. JAMA 2014,312(13),1330-1341","journal-title":"JAMA"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1128\/AAC.00973-09","volume":"54","author":"Ragle B.E.","year":"2010","unstructured":"Ragle B.E.; Karginov V.A.; Bubeck W.J.; Prevention and treatment of Staphylococcus aureus pneumonia with a beta-cyclodextrin derivative. Antimicrob Agents Chemother 2010,54(1),298-304","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1741-7015-6-2","volume":"6","author":"Delaney J.A.C.","year":"2008","unstructured":"Delaney J.A.C.; Schneider-Lindner V.; Brassard P.; Suissa S.; Mortality after infection with methicillin-resistant Staphylococcus aureus (MRSA) diagnosed in the community. BMC Med 2008,6(1),2","journal-title":"BMC Med"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"071","DOI":"10.4103\/0974-2727.119843","volume":"5","author":"Tarai B","year":"2013","unstructured":"Tarai B; Das P; Kumar D; Recurrent challenges for clinicians:\nemergence of methicillin-resistant Staphylococcus aureus, vancomycin\nresistance, and current treatment options. J Lab Physicians 2013,5(2),071-8","journal-title":"J Lab Physicians"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jhin.2019.08.024","volume":"104","author":"Skj\u00f8t-Arkil H.","year":"2020","unstructured":"Skj\u00f8t-Arkil H.; Mogensen C.B.; Lassen A.T.; Detection of meticillin-resistant Staphylococcus aureus and carbapenemase-producing Enterobacteriaceae in Danish emergency departments \u2013 evaluation of national screening guidelines. J Hosp Infect 2020,104(1),27-32","journal-title":"J Hosp Infect"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"58086","DOI":"10.18632\/oncotarget.19491","volume":"8","author":"Liu X.","year":"2017","unstructured":"Liu X.; Deng S.; Huang J.; Dissemination of macrolides, fusidic acid and mupirocin resistance among Staphylococcus aureus clinical isolates. Oncotarget 2017,8(35),58086-58097","journal-title":"Oncotarget"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.kjms.2017.08.001","volume":"33","author":"Khosravi A.D.","year":"2017","unstructured":"Khosravi A.D.; Jenabi A.; Montazeri E.A.; Distribution of genes encoding resistance to aminoglycoside modifying enzymes in methicillin-resistant Staphylococcus aureus (MRSA) strains. Kaohsiung J Med Sci 2017,33(12),587-593","journal-title":"Kaohsiung J Med Sci"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1128\/JCM.02274-06","volume":"45","author":"Han L.L.","year":"2007","unstructured":"Han L.L.; McDougal L.K.; Gorwitz R.J.; High frequencies of clindamycin and tetracycline resistance in methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at a Boston ambulatory health center. J Clin Microbiol 2007,45(4),1350-1352","journal-title":"J Clin Microbiol"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.1038\/s41598-021-83578-2","volume":"11","author":"Alseqely M.","year":"2021","unstructured":"Alseqely M.; Newton-Foot M.; Khalil A.; El-Nakeeb M.; Whitelaw A.; Abouelfetouh A.; Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt. Sci Rep 2021,11(1),4253","journal-title":"Sci Rep"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3389\/fmicb.2020.01414","volume":"11","author":"Chen C.J.","year":"2020","unstructured":"Chen C.J.; Huang Y.C.; Shie S.S.; Evolution of multi-resistance to vancomycin, daptomycin, and linezolid in methicillin-resistant Staphylococcus aureus causing persistent bacteremia. Front Microbiol 2020,11,1414","journal-title":"Front Microbiol"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/iub.1289","volume":"66","author":"Fishovitz J.","year":"2014","unstructured":"Fishovitz J.; Hermoso J.A.; Chang M.; Mobashery S.; Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. IUBMB Life 2014,66(8),572-577","journal-title":"IUBMB Life"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.micpath.2016.10.028","volume":"101","author":"Liu J.","year":"2016","unstructured":"Liu J.; Chen D.; Peters B.M.; Staphylococcal chromosomal cassettes mec (SCCmec): A mobile genetic element in methicillin-resistant Staphylococcus aureus. Microb Pathog 2016,101,56-67","journal-title":"Microb Pathog"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"637656","DOI":"10.3389\/fmicb.2021.637656","volume":"12","author":"Turner A.M.","year":"2021","unstructured":"Turner A.M.; Lee J.Y.H.; Gorrie C.L.; Howden B.P.; Carter G.P.; Genomic insights into last-line antimicrobial resistance in multidrug-resistant Staphylococcus and vancomycin-resistant Enterococcus. Front Microbiol 2021,12,637656","journal-title":"Front Microbiol"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12275-016-5159-z","volume":"54","author":"Jang S.","year":"2016","unstructured":"Jang S.; Multidrug efflux pumps in Staphylococcus aureus and their clinical implications. J Microbiol 2016,54(1),1-8","journal-title":"J Microbiol"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.meegid.2013.03.020","volume":"21","author":"Sollid J.U.E.","year":"2014","unstructured":"Sollid J.U.E.; Furberg A.S.; Hanssen A.M.; Johannessen M.; Staphylococcus aureus: Determinants of human carriage. Infect Genet Evol 2014,21,531-541","journal-title":"Infect Genet Evol"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.3389\/fmicb.2018.02419","volume":"9","author":"Sakr A.","year":"2018","unstructured":"Sakr A.; Br\u00e9geon F.; M\u00e8ge J.L.; Rolain J.M.; Blin O.; Staphylococcus aureus nasal colonization: An update on mechanisms, epidemiology, risk factors, and subsequent infections. Front Microbiol 2018,9,2419","journal-title":"Front Microbiol"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3390\/microorganisms9030631","volume":"9","author":"Fernandes de Oliveira L.M.","year":"2021","unstructured":"Fernandes de Oliveira L.M.; Steindorff M.; Darisipudi M.N.; Discovery of Staphylococcus aureus adhesion inhibitors by automated imaging and their characterization in a mouse model of persistent nasal colonization. Microorganisms 2021,9(3),631","journal-title":"Microorganisms"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"e1400216","DOI":"10.1126\/sciadv.1400216","volume":"1","author":"Liu C.M.","year":"2015","unstructured":"Liu C.M.; Price L.B.; Hungate B.A.; Staphylococcus aureus and the ecology of the nasal microbiome. Sci Adv 2015,1(5),e1400216","journal-title":"Sci Adv"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"71R","DOI":"10.1203\/PDR.0b013e31819dc44d","volume":"65","author":"Liu G.Y.","year":"2009","unstructured":"Liu G.Y.; Molecular pathogenesis of Staphylococcus aureus infection. Pediatr Res 2009,65(5 Part 2),71R-77R","journal-title":"Pediatr Res"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"13863","DOI":"10.1074\/jbc.275.18.13863","volume":"275","author":"Wann E.R.","year":"2000","unstructured":"Wann E.R.; Gurusiddappa S.; H\u00f6k M.; The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen. J Biol Chem 2000,275(18),13863-13871","journal-title":"J Biol Chem"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1128\/iai.62.1.152-161.1994","volume":"62","author":"Patti J.M.","year":"1994","unstructured":"Patti J.M.; Bremell T.; Krajewska-Pietrasik D.; The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis. Infect Immun 1994,62(1),152-161","journal-title":"Infect Immun"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"e1002434","DOI":"10.1371\/journal.ppat.1002434","volume":"8","author":"Guggenberger C.","year":"2012","unstructured":"Guggenberger C.; Wolz C.; Morrissey J.A.; Heesemann J.; Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model. PLoS Pathog 2012,8(1),e1002434","journal-title":"PLoS Pathog"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrmicro3521","volume":"13","author":"Thammavongsa V.","year":"2015","unstructured":"Thammavongsa V.; Kim H.K.; Missiakas D.; Schneewind O.; Staphylococcal manipulation of host immune responses. Nat Rev Microbiol 2015,13(9),529-543","journal-title":"Nat Rev Microbiol"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1038\/nm1207-1405","volume":"13","author":"Bubeck Wardenburg J.","year":"2007","unstructured":"Bubeck Wardenburg J.; Bae T.; Otto M.; DeLeo F.R.; Schneewind O.; Poring over pores: \u03b1-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 2007,13(12),1405-1406","journal-title":"Nat Med"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrmicro.2017.27","volume":"15","author":"Spaan A.N.","year":"2017","unstructured":"Spaan A.N.; van Strijp J.A.G.; Torres V.J.; Leukocidins: Staphylococcal bi-component pore-forming toxins find their receptors. Nat Rev Microbiol 2017,15(7),435-447","journal-title":"Nat Rev Microbiol"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1365-2249.2005.02963.x","volume":"143","author":"Wagner C.","year":"2005","unstructured":"Wagner C.; Iking-Konert C.; Hug F.; Cellular inflammatory response to persistent localized Staphylococcus aureus infection: phenotypical and functional characterization of polymorphonuclear neutrophils (PMN). Clin Exp Immunol 2005,143(1),70-77","journal-title":"Clin Exp Immunol"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1471-2172-13-38","volume":"13","author":"Cheng P.","year":"2012","unstructured":"Cheng P.; Liu T.; Zhou W.Y.; Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia. BMC Immunol 2012,13(1),38","journal-title":"BMC Immunol"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"e1007112","DOI":"10.1371\/journal.ppat.1007112","volume":"14","author":"Pollitt E.J.G.","year":"2018","unstructured":"Pollitt E.J.G.; Szkuta P.T.; Burns N.; Foster S.J.; Staphylococcus aureus infection dynamics. PLoS Pathog 2018,14(6),e1007112","journal-title":"PLoS Pathog"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"16059","DOI":"10.1038\/nrdp.2016.59","volume":"2","author":"Holland T.L.","year":"2016","unstructured":"Holland T.L.; Baddour L.M.; Bayer A.S.; Hoen B.; Miro J.M.; Fowler V.G.; Infective endocarditis. Nat Rev Dis Primers 2016,2(1),16059","journal-title":"Nat Rev Dis Primers"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.meegid.2015.08.029","volume":"36","author":"Bouchiat C.","year":"2015","unstructured":"Bouchiat C.; Moreau K.; Devillard S.; Staphylococcus aureus infective endocarditis versus bacteremia strains: Subtle genetic differences at stake. Infect Genet Evol 2015,36,524-530","journal-title":"Infect Genet Evol"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1590\/S1413-86702001000300001","volume":"5","author":"Bilevicius E.","year":"2001","unstructured":"Bilevicius E.; Dragosavac D.; Dragosavac S.; Ara\u00fajo S.; Falc\u00e3o A.L.E.; Terzi R.G.G.; Multiple organ failure in septic patients. Braz J Infect Dis 2001,5(3),103-110","journal-title":"Braz J Infect Dis"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ijid.2005.01.006","volume":"10","author":"Miwa K.","year":"2006","unstructured":"Miwa K.; Fukuyama M.; Matsuno N.; Superantigen-induced multiple organ dysfunction in a toxin-concentration-controlled and sequential parameter-monitored swine sepsis model. Int J Infect Dis 2006,10(1),14-24","journal-title":"Int J Infect Dis"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1086\/322610","volume":"33","author":"Wisplinghoff H.","year":"2001","unstructured":"Wisplinghoff H.; Seifert H.; Coimbra M.; Wenzel R.P.; Edmond M.B.; Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Staphylococcus aureus. Clin Infect Dis 2001,33(5),733-736","journal-title":"Clin Infect Dis"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"345","DOI":"10.12659\/MSM.892528","volume":"21","author":"Marques L.M.","year":"2015","unstructured":"Marques L.M.; Amorin A.T.; Rezende I.S.; Sepsis induced by Staphylococcus aureus: participation of biomarkers in a murine model. Med Sci Monit 2015,21,345-355","journal-title":"Med Sci Monit"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1155\/2007\/253947","volume":"18","author":"Goetghebeur M.","year":"2007","unstructured":"Goetghebeur M.; Landry P.A.; Han D.; Vicente C.; Methicillin-resistant Staphylococcus aureus: A public health issue with economic consequences. Can J Infect Dis Med Microbiol 2007,18(1),27-34","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fpubh.2017.00044","volume":"5","author":"Dickmann P.","year":"2017","unstructured":"Dickmann P.; Keeping S.; D\u00f6ring N.; Communicating the risk of MRSA: The role of clinical practice, regulation and other policies in five european countries. Front Public Health 2017,5,44","journal-title":"Front Public Health"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1155\/2003\/197126","volume":"14","author":"Conly J.M.","year":"2003","unstructured":"Conly J.M.; Johnston B.L.; The emergence of methicillin-resistant Staphylococcus aureus as a community-acquired pathogen in Canada. Can J Infect Dis 2003,14(5),249-251","journal-title":"Can J Infect Dis"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1073\/pnas.0710217105","volume":"105","author":"Kennedy A.D.","year":"2008","unstructured":"Kennedy A.D.; Otto M.; Braughton K.R.; Epidemic community-associated methicillin-resistant Staphylococcus aureus: Recent clonal expansion and diversification. Proc Natl Acad Sci USA 2008,105(4),1327-1332","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ijmm.2013.02.007","volume":"303","author":"Otto M.","year":"2013","unstructured":"Otto M.; Community-associated MRSA: What makes them special? Int J Med Microbiol 2013,303(6-7),324-330","journal-title":"Int J Med Microbiol"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"17916","DOI":"10.1038\/s41598-018-36206-5","volume":"8","author":"Peng H.","year":"2018","unstructured":"Peng H.; Liu D.; Ma Y.; Gao W.; Comparison of community- and healthcare-associated methicillin-resistant Staphylococcus aureus isolates at a Chinese tertiary hospital, 2012\u20132017. Sci Rep 2018,8(1),17916","journal-title":"Sci Rep"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"e00468","DOI":"10.1128\/AAC.00468-20","volume":"64","author":"Molina K.C.","year":"2020","unstructured":"Molina K.C.; Morrisette T.; Miller M.A.; Huang V.; Fish D.N.; The emerging role of \u03b2-lactams in the treatment of methicillin-resistant Staphylococcus aureus bloodstream infections. Antimicrob Agents Chemother 2020,64(7),e00468-e20","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"e1008672","DOI":"10.1371\/journal.ppat.1008672","volume":"16","author":"Panchal V.V.","year":"2020","unstructured":"Panchal V.V.; Griffiths C.; Mosaei H.; Evolving MRSA: High-level \u03b2-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression. PLoS Pathog 2020,16(7),e1008672","journal-title":"PLoS Pathog"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"e00880","DOI":"10.1128\/mBio.00880-19","volume":"10","author":"Shang W","year":"2019","unstructured":"Shang W; Rao Y; Zheng Y; \u03b2-Lactam antibiotics enhance the\npathogenicity of methicillin-resistant Staphylococcus aureus via\nSarA-Controlled lipoprotein-like cluster expression. MBio 2019,10(3),e00880-e19","journal-title":"MBio"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1445-5994.2011.02452.x","volume":"41","author":"Avent M.L.","year":"2011","unstructured":"Avent M.L.; Rogers B.A.; Cheng A.C.; Paterson D.L.; Current use of aminoglycosides: Indications, pharmacokinetics and monitoring for toxicity. Intern Med J 2011,41(6),441-449","journal-title":"Intern Med J"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2165\/00003495-198700342-00009","volume":"34","author":"Norrby S.R.","year":"1987","unstructured":"Norrby S.R.; Side effects of cephalosporins. Drugs 1987,34(S2),105-120","journal-title":"Drugs"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/BF01967014","volume":"10","author":"Norrby S.R.","year":"1991","unstructured":"Norrby S.R.; Side-effects of quinolones: Comparisons between quinolones and other antibiotics. Eur J Clin Microbiol Infect Dis 1991,10(4),378-383","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1586\/14787210.2015.1068118","volume":"13","author":"Henson K.E.R.","year":"2015","unstructured":"Henson K.E.R.; Levine M.T.; Wong E.A.H.; Levine D.P.; Glycopeptide antibiotics: Evolving resistance, pharmacology and adverse event profile. Expert Rev Anti Infect Ther 2015,13(10),1265-1278","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref=97","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4064-1.00031-2","author":"Greenwood D.","year":"2010","unstructured":"Greenwood D.; Miscellaneous antibacterial agents. Antibiotic and Chemotherapy 2010","journal-title":"Antibiotic and Chemotherapy"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3390\/toxins13050347","volume":"13","author":"Lenz K.D.","year":"2021","unstructured":"Lenz K.D.; Klosterman K.E.; Mukundan H.; Kubicek-Sutherland J.Z.; Macrolides: From toxins to therapeutics. Toxins 2021,13(5),347","journal-title":"Toxins"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1155\/2001\/260651","volume":"12","author":"Zhanel G.G.","year":"2001","unstructured":"Zhanel G.G.; Schroeder C.; Vercaigne L.; Gin A.S.; Embil J.; Hoban D.J.; A critical review of oxazolidinones: An alternative or replacement for glycopeptides and streptogramins? Can J Infect Dis 2001,12(6),379-390","journal-title":"Can J Infect Dis"},{"key":"ref=100","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4064-1.00027-0","author":"Parenti F.","year":"2010","unstructured":"Parenti F.; Lancini G.; Rifamycins. Antibiotic and Chemotherapy 2010","journal-title":"Antibiotic and Chemotherapy"},{"key":"ref=101","author":"Kemnic TR","year":"2021","unstructured":"Kemnic TR; Coleman M;  Trimethoprim Sulfamethoxazole 2021","journal-title":"Trimethoprim Sulfamethoxazole"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/j.1365-4632.2004.02108.x","volume":"43","author":"S\u00e1nchez A.R.","year":"2004","unstructured":"S\u00e1nchez A.R.; Rogers R.S.; Sheridan P.J.; Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity. Int J Dermatol 2004,43(10),709-715","journal-title":"Int J Dermatol"},{"key":"ref=103","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.70199","author":"Bozcal E.","year":"2017","unstructured":"Bozcal E.; Dagdeviren M.; Toxicity of \u03b2-lactam antibiotics: Pathophysiology, molecular biology and possible recovery strategies, poisoning. Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis 2017","journal-title":"Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3947\/ic.2016.48.4.267","volume":"48","author":"Choo E.J.","year":"2016","unstructured":"Choo E.J.; Chambers H.F.; Treatment of methicillin-resistant Staphylococcus aureus Bacteremia. Infect Chemother 2016,48(4),267-273","journal-title":"Infect Chemother"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"e00528","DOI":"10.1128\/Spectrum.00528-21","volume":"9","author":"Hort M.","year":"2021","unstructured":"Hort M.; Bertsche U.; Nozinovic S.; The Role of \u03b2-Glycosylated wall teichoic acids in the reduction of vancomycin susceptibility in vancomycin-intermediate Staphylococcus aureus. Microbiol Spectr 2021,9(2),e00528-e21","journal-title":"Microbiol Spectr"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13756-021-00967-y","volume":"10","author":"Wu Q.","year":"2021","unstructured":"Wu Q.; Sabokroo N.; Wang Y.; Hashemian M.; Karamollahi S.; Kouhsari E.; Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates. Antimicrob Resist Infect Control 2021,10(1),101","journal-title":"Antimicrob Resist Infect Control"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/cpt.726","volume":"102","author":"Filippone E.J.","year":"2017","unstructured":"Filippone E.J.; Kraft W.K.; Farber J.L.; The nephrotoxicity of vancomycin. Clin Pharmacol Ther 2017,102(3),459-469","journal-title":"Clin Pharmacol Ther"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"159","DOI":"10.7547\/0003-0538-104.2.159","volume":"104","author":"Joseph W.S.","year":"2014","unstructured":"Joseph W.S.; Quast T.; Cogo A.; Daptomycin for methicillin-resistant Staphylococcus aureus diabetic foot infections. J Am Podiatr Med Assoc 2014,104(2),159-168","journal-title":"J Am Podiatr Med Assoc"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"3080","DOI":"10.3389\/fmicb.2019.03080","volume":"10","author":"Zhou Y.F.","year":"2020","unstructured":"Zhou Y.F.; Li L.; Tao M.T.; Linezolid and rifampicin combination to combat cfr-positive multidrug-resistant MRSA in murine models of bacteremia and skin and skin structure infection. Front Microbiol 2020,10,3080","journal-title":"Front Microbiol"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/1120009X.2021.1931758","volume":"33","author":"Wei X.","year":"2021","unstructured":"Wei X.; Zhao M.; Xiao X.; Optimization of dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus in neutropenic patients with cancer by Monte Carlo simulations. J Chemother 2021,33(8),547-553","journal-title":"J Chemother"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jep.2005.04.025","volume":"100","author":"R\u00edos J.L.","year":"2005","unstructured":"R\u00edos J.L.; Recio M.C.; Medicinal plants and antimicrobial activity. J Ethnopharmacol 2005,100(1-2),80-84","journal-title":"J Ethnopharmacol"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3389\/fmicb.2012.00287","volume":"3","author":"Lucera A.","year":"2012","unstructured":"Lucera A.; Costa C.; Conte A.; Del Nobile M.A.; Food applications of natural antimicrobial compounds. Front Microbiol 2012,3(287),287","journal-title":"Front Microbiol"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/246264","volume":"2015","author":"Hintz T.","year":"2015","unstructured":"Hintz T.; Matthews K.K.; Di R.; The use of plant antimicrobial compounds for food preservation. BioMed Res Int 2015,2015(246264),1-12","journal-title":"BioMed Res Int"},{"key":"ref=114","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1128\/CMR.12.4.564","volume":"12","author":"Cowan M.M.","year":"1999","unstructured":"Cowan M.M.; Plant products as antimicrobial agents. Clin Microbiol Rev 1999,12(4),564-582","journal-title":"Clin Microbiol Rev"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1002\/biot.200600130","volume":"1","author":"Aqil F.","year":"2006","unstructured":"Aqil F.; Ahmad I.; Owais M.; Evaluation of anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and synergy of some bioactive plant extracts. Biotechnol J 2006,1(10),1093-1102","journal-title":"Biotechnol J"},{"key":"ref=116","first-page":"1","volume":"7","author":"Aliyu A.B.","year":"2008","unstructured":"Aliyu A.B.; Musa A.M.; Abdullahi M.S.; Oyewale A.O.; Gwarzo U.S.; Activity of plant extracts used in northern Nigerian traditional\nmedicine against methicillin-resistant Staphylococcus aureus\n(MRSA). Niger J Pharm Sci 2008,7(1),1-8","journal-title":"Niger J Pharm Sci"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.3390\/molecules17032955","volume":"17","author":"Zuo G.Y.","year":"2012","unstructured":"Zuo G.Y.; Zhang X.J.; Yang C.X.; Han J.; Wang G.C.; Bian Z.Q.; Evaluation of traditional Chinese medicinal plants for anti-MRSA activity with reference to the treatment record of infectious diseases. Molecules 2012,17(3),2955-2967","journal-title":"Molecules"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"5884","DOI":"10.1016\/j.sjbs.2021.06.036","volume":"28","author":"Yi Xin L.","year":"2021","unstructured":"Yi Xin L.; Hui Min T.; Liyana N.M.Z.P.; Pulingam T.; Nelson A.J.; Parumasivam T.; Antibacterial potential of Malaysian ethnomedicinal plants against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). Saudi J Biol Sci 2021,28(10),5884-5889","journal-title":"Saudi J Biol Sci"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1002\/ptr.6665","volume":"34","author":"Salehi B.","year":"2020","unstructured":"Salehi B.; Konovalov D.A.; Fru P.; Areca catechu-From farm to food and biomedical applications. Phytother Res 2020,34(9),2140-2158","journal-title":"Phytother Res"},{"key":"ref=120","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.indcrop.2016.10.046","volume":"95","author":"Svobodova B.","year":"2017","unstructured":"Svobodova B.; Barros L.; Calhelha R.C.; Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago. Ind Crops Prod 2017,95,365-373","journal-title":"Ind Crops Prod"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.foodres.2018.08.041","volume":"116","author":"Ziani B.E.C.","year":"2019","unstructured":"","journal-title":"Food Res Int"},{"key":"ref=122","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1039\/C7FO01315A","volume":"9","author":"Ziani B.E.C.","year":"2018","unstructured":"Ziani B.E.C.; Barros L.; Boumehira A.Z.; Profiling polyphenol composition by HPLC-DAD-ESI\/MSn and the antibacterial activity of infusion preparations obtained from four medicinal plants. Food Funct 2018,9(1),149-159","journal-title":"Food Funct"},{"key":"ref=123","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.3390\/plants9111539","volume":"9","author":"Buzgaia N.","year":"2020","unstructured":"Buzgaia N.; Awin T.; Elabbar F.; Antibacterial activity of Arbutus pavarii pamp against methicillin-resistant Staphylococcus aureus (MRSA) and UHPLC-MS\/MS profile of the bioactive fraction. Plants 2020,9(11),1539","journal-title":"Plants"},{"key":"ref=124","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12906-018-2137-5","volume":"18","author":"Chew Y.L.","year":"2018","unstructured":"Chew Y.L.; Mahadi A.M.; Wong K.M.; Goh J.K.; Anti-methicillin-resistance Staphylococcus aureus (MRSA) compounds from Bauhinia kockiana Korth. And their mechanism of antibacterial activity. BMC Complement Altern Med 2018,18(1),70","journal-title":"BMC Complement Altern Med"},{"key":"ref=125","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.joim.2018.07.005","volume":"16","author":"Chakraborty S.","year":"2018","unstructured":"Chakraborty S.; Afaq N.; Singh N.; Majumdar S.; Antimicrobial activity of Cannabis sativa, Thuja orientalis and Psidium guajava leaf extracts against methicillin-resistant Staphylococcus aureus. J Integr Med 2018,16(5),350-357","journal-title":"J Integr Med"},{"key":"ref=126","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.fbio.2018.09.003","volume":"26","author":"Prabakaran M.","year":"2018","unstructured":"Prabakaran M.; Kim S.H.; Sasireka A.; Chandrasekaran M.; Chung I.M.; Polyphenol composition and antimicrobial activity of various solvent extracts from different plant parts of Moringa oleifera. Food Biosci 2018,26,23-29","journal-title":"Food Biosci"},{"key":"ref=127","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1055\/s-0030-1250736","volume":"77","author":"van Vuuren S.","year":"2011","unstructured":"van Vuuren S.; Viljoen A.; Plant-based antimicrobial studies-methods and approaches to study the interaction between natural products. Planta Med 2011,77(11),1168-1182","journal-title":"Planta Med"},{"key":"ref=128","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3390\/antibiotics8040257","volume":"8","author":"Mickymaray S.","year":"2019","unstructured":"Mickymaray S.; Efficacy and mechanism of traditional medicinal plants and bioactive compounds against clinically important pathogens. Antibiotics 2019,8(4),257","journal-title":"Antibiotics"},{"key":"ref=129","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.3390\/molecules24061024","volume":"24","author":"Bocquet L.","year":"2019","unstructured":"Bocquet L.; Sahpaz S.; Bonneau N.; Phenolic compounds from Humulus lupulus as natural antimicrobial products: New weapons in the fight against methicillin resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei strains. Molecules 2019,24(6),1024","journal-title":"Molecules"},{"key":"ref=130","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1080\/08927014.2016.1208183","volume":"32","author":"Silva S.","year":"2016","unstructured":"Silva S.; Costa E.M.; Horta B.; Calhau C.; Morais R.M.; Pintado M.M.; Anti-biofilm potential of phenolic acids: the influence of environmental pH and intrinsic physico-chemical properties. Biofouling 2016,32(8),853-860","journal-title":"Biofouling"},{"key":"ref=131","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","volume":"15","author":"Hemaiswarya S.","year":"2008","unstructured":"Hemaiswarya S.; Kruthiventi A.K.; Doble M.; Synergism between natural products and antibiotics against infectious diseases. Phytomedicine 2008,15(8),639-652","journal-title":"Phytomedicine"},{"key":"ref=132","doi-asserted-by":"publisher","first-page":"186","DOI":"10.18683\/germs.2017.1125","volume":"7","author":"Adnan S.N.A.","year":"2017","unstructured":"Adnan S.N.A.; Ibrahim N.; Yaacob W.A.; Disruption of methicillin-resistant Staphylococcus aureus protein synthesis by tannins. Germs 2017,7(4),186-192","journal-title":"Germs"},{"key":"ref=133","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.3390\/molecules25081986","volume":"25","author":"Taylor P.W.","year":"2020","unstructured":"Taylor P.W.; Interactions of tea-derived catechin gallates with bacterial pathogens. Molecules 2020,25(8),1986","journal-title":"Molecules"},{"key":"ref=134","doi-asserted-by":"publisher","first-page":"8279","DOI":"10.1007\/s00253-020-10853-z","volume":"104","author":"Sinsinwar S.","year":"2020","unstructured":"Sinsinwar S.; Vadivel V.; Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress. Appl Microbiol Biotechnol 2020,104(19),8279-8297","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref=135","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1053\/jhin.2002.1327","volume":"53","author":"Yamada H.","year":"2003","unstructured":"Yamada H.; Ohashi K.; Atsumi T.; Effects of tea catechin inhalation on methicillin-resistant Staphylococcus aureus in elderly patients in a hospital ward. J Hosp Infect 2003,53(3),229-231","journal-title":"J Hosp Infect"},{"key":"ref=136","doi-asserted-by":"publisher","first-page":"315","DOI":"10.17179\/excli2016-277","volume":"15","author":"Tintino S.R.","year":"2016","unstructured":"Tintino S.R.; Morais-Tintino C.D.; Campina F.F.; Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps. EXCLI J 2016,15,315-322","journal-title":"EXCLI J"},{"key":"ref=137","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.phymed.2017.09.011","volume":"36","author":"Pierpaoli E.","year":"2017","unstructured":"Pierpaoli E.; Orlando F.; Cirioni O.; Simonetti O.; Giacometti A.; Provinciali M.; Supplementation with tocotrienols from Bixa orellana improves the in vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a mouse model of infected wound. Phytomedicine 2017,36,50-53","journal-title":"Phytomedicine"},{"key":"ref=138","doi-asserted-by":"publisher","first-page":"S153","DOI":"10.1080\/10408398.2018.1541865","volume":"59","author":"Li J","year":"2019","unstructured":"Li J; Liu D; Tian X; Novel antibacterial modalities against\nmethicillin resistant Staphylococcus aureus derived from plants. Crit Rev Food Sci Nutr 2019,59(sup1),S153-61","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref=139","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1021\/acs.orglett.0c00903","volume":"22","author":"Chen D.","year":"2020","unstructured":"Chen D.; Sun Z.; Liu Y.; Eleucanainones A and B: Two dimeric structures from the bulbs of Eleutherine americana with anti-MRSA Activity. Org Lett 2020,22(9),3449-3453","journal-title":"Org Lett"},{"key":"ref=140","doi-asserted-by":"publisher","first-page":"14180","DOI":"10.1038\/s41598-021-92964-9","volume":"11","author":"Kalli S.","year":"2021","unstructured":"Kalli S.; Araya-Cloutier C.; Hageman J.; Vincken J.P.; Insights into the molecular properties underlying antibacterial activity of prenylated (iso)flavonoids against MRSA. Sci Rep 2021,11(1),14180","journal-title":"Sci Rep"},{"key":"ref=141","doi-asserted-by":"publisher","first-page":"5631","DOI":"10.5897\/AJMR12.126","volume":"6","author":"Johari S.A.","year":"2012","unstructured":"Johari S.A.; Kiong L.S.; Mohtar M.; Efflux inhibitory activity of flavonoids from Chromolaena odorata against selected methicillin-resistant Staphylococcus aureus (MRSA) isolates. Afr J Microbiol Res 2012,6(27),5631-5635","journal-title":"Afr J Microbiol Res"},{"key":"ref=142","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3390\/antibiotics9090562","volume":"9","author":"Alhadrami H.A.","year":"2020","unstructured":"Alhadrami H.A.; Hamed A.A.; Hassan H.M.; Belbahri L.; Rateb M.E.; Sayed A.M.; Flavonoids as potential anti-mrsa agents through modulation of PBP2a: A computational and experimental study. Antibiotics 2020,9(9),562","journal-title":"Antibiotics"},{"key":"ref=143","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1111\/j.1365-2621.2010.02267.x","volume":"45","author":"Hirai I.","year":"2010","unstructured":"Hirai I.; Okuno M.; Katsuma R.; Arita N.; Tachibana M.; Yamamoto Y.; Characterisation of anti-Staphylococcus aureus activity of quercetin. Int J Food Sci Technol 2010,45(6),1250-1254","journal-title":"Int J Food Sci Technol"},{"key":"ref=144","doi-asserted-by":"publisher","first-page":"e02340","DOI":"10.1128\/spectrum.02340-21","volume":"10","author":"Jing S.","year":"2022","unstructured":"Jing S.; Kong X.; Wang L.; Quercetin reduces the virulence of S. aureus by targeting ClpP to protect mice from MRSA-induced lethal pneumonia. Microbiol Spectr 2022,10(2),e02340-e21","journal-title":"Microbiol Spectr"},{"key":"ref=145","doi-asserted-by":"publisher","first-page":"100751","DOI":"10.1016\/j.fbio.2020.100751","volume":"38","author":"Farha A.K.","year":"2020","unstructured":"Farha A.K.; Yang Q.Q.; Kim G.; Tannins as an alternative to antibiotics. Food Biosci 2020,38,100751","journal-title":"Food Biosci"},{"key":"ref=146","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.lwt.2018.10.047","volume":"100","author":"Liu M.","year":"2019","unstructured":"Liu M.; Yang K.; Wang J.; Young astringent persimmon tannin inhibits methicillin-resistant Staphylococcus aureus isolated from pork. Lebensm Wiss Technol 2019,100,48-55","journal-title":"Lebensm Wiss Technol"},{"key":"ref=147","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/antibiotics8040251","volume":"8","author":"Nolan V.C.","year":"2019","unstructured":"Nolan V.C.; Harrison J.; Cox J.A.G.; Dissecting the antimicrobial composition of honey. Antibiotics 2019,8(4),251","journal-title":"Antibiotics"},{"key":"ref=148","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fmicb.2012.00036","volume":"3","author":"Brudzynski K.","year":"2012","unstructured":"Brudzynski K.; Lannigan R.; Mechanism of honey bacteriostatic action against MRSA and VRE involves hydroxyl radicals generated from honey\u2019s hydrogen peroxide. Front Microbiol 2012,3,36","journal-title":"Front Microbiol"},{"key":"ref=149","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/jac\/dkt430","volume":"69","author":"Jenkins R.","year":"2014","unstructured":"Jenkins R.; Burton N.; Cooper R.; Proteomic and genomic analysis of methicillin-resistant Staphylococcus aureus (MRSA) exposed to manuka honey in vitro demonstrated down-regulation of virulence markers. J Antimicrob Chemother 2014,69(3),603-615","journal-title":"J Antimicrob Chemother"},{"key":"ref=150","doi-asserted-by":"publisher","first-page":"325","DOI":"10.12968\/jowc.2007.16.8.27851","volume":"16","author":"Blaser G.","year":"2007","unstructured":"Blaser G.; Santos K.; Bode U.; Vetter H.; Simon A.; Effect of medical honey on wounds colonised or infected with MRSA. J Wound Care 2007,16(8),325-328","journal-title":"J Wound Care"},{"key":"ref=151","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.3390\/molecules17043989","volume":"17","author":"Bassol\u00e9 I.H.N.","year":"2012","unstructured":"Bassol\u00e9 I.H.N.; Juliani H.R.; Essential oils in combination and their antimicrobial properties. Molecules 2012,17(4),3989-4006","journal-title":"Molecules"},{"key":"ref=152","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/ffj.1904","volume":"23","author":"Chao S.","year":"2008","unstructured":"Chao S.; Young G.; Oberg C.; Nakaoka K.; Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by essential oils. Flavour Fragrance J 2008,23(6),444-449","journal-title":"Flavour Fragrance J"},{"key":"ref=153","doi-asserted-by":"publisher","first-page":"100971","DOI":"10.1016\/j.disamonth.2020.100971","volume":"66","author":"Abushaheen MA.","year":"2020","unstructured":"Abushaheen MA.; Muzaheed ; Fatani AJ.; Antimicrobial resistance, mechanisms and its clinical significance. Dis Mon 2020,66(6),100971","journal-title":"Dis Mon"},{"key":"ref=154","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","volume":"9","author":"Roy R.","year":"2018","unstructured":"Roy R.; Tiwari M.; Donelli G.; Tiwari V.; Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action. Virulence 2018,9(1),522-554","journal-title":"Virulence"},{"key":"ref=155","doi-asserted-by":"publisher","first-page":"110959","DOI":"10.1016\/j.biopha.2020.110959","volume":"133","author":"Behl T.","year":"2021","unstructured":"Behl T.; Kumar K.; Brisc C.; Exploring the multifocal role of phytochemicals as immunomodulators. Biomed Pharmacother 2021,133,110959","journal-title":"Biomed Pharmacother"},{"key":"ref=156","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13567-018-0562-6","volume":"49","author":"Lillehoj H.","year":"2018","unstructured":"Lillehoj H.; Liu Y.; Calsamiglia S.; Phytochemicals as antibiotic alternatives to promote growth and enhance host health. Vet Res 2018,49(1),76","journal-title":"Vet Res"},{"key":"ref=157","doi-asserted-by":"publisher","first-page":"5517","DOI":"10.1021\/ol802249z","volume":"10","author":"Wang Y.","year":"2008","unstructured":"Wang Y.; Shen Y.H.; Jin H.Z.; Ainsliatrimers A and B, the first two guaianolide trimers from Ainsliaea fulvioides. Org Lett 2008,10(24),5517-5520","journal-title":"Org Lett"},{"key":"ref=158","doi-asserted-by":"publisher","first-page":"104183","DOI":"10.1016\/j.bioorg.2020.104183","volume":"104","author":"Hamann HJ","year":"2020","unstructured":"Hamann HJ; Abutaleb NS; Pal R; Seleem MN; Ramachandran PV; \u03b2,\u03b3-Diaryl \u03b1-methylene-\u03b3-butyrolactones as potent antibacterials\nagainst methicillin-resistant Staphylococcus aureus. Bioorg Chem 2020,104,104183","journal-title":"Bioorg Chem"},{"key":"ref=159","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/lam.13369","volume":"71","author":"Meah M.S.","year":"2020","unstructured":"Meah M.S.; Lertcanawanichakul M.; Pedpradab P.; Synergistic\neffect on anti\u2010methicillin\u2010resistant Staphylococcus aureus among\ncombinations of \u03b1\u2010mangostin\u2010rich extract, lawsone methyl ether\nand ampicillin. Lett Appl Microbiol 2020,71(5),510-519","journal-title":"Lett Appl Microbiol"},{"key":"ref=160","first-page":"853","volume":"16","author":"Choi J.G.","year":"2012","unstructured":"Choi J.G.; Lee M.W.; Choi S.E.; Antibacterial activity of bark of\nAlnus pendula against methicillin-resistant Staphylococcus aureus. Eur Rev Med Pharmacol Sci 2012,16(7),853-859","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref=161","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.3390\/molecules26041114","volume":"26","author":"Al-Majmaie S.","year":"2021","unstructured":"Al-Majmaie S.; Nahar L.; Rahman M.M.; Anti-MRSA Constituents\nfrom Ruta chalepensis (Rutaceae) grown in Iraq, and in silico\nstudies on two of most active compounds, chalepensin and\n6-hydroxy-rutin 3\u2032,7-dimethyl ether. Molecules 2021,26(4),1114","journal-title":"Molecules"},{"key":"ref=162","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12906-015-0938-3","volume":"15","author":"Zuo G.Y.","year":"2015","unstructured":"Zuo G.Y.; Zhang X.J.; Han J.; Li Y.Q.; Wang G.C.; In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). BMC Complement Altern Med 2015,15(1),425","journal-title":"BMC Complement Altern Med"}],"container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1381612829666230410095155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/215596\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1381612829666230410095155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:50:34Z","timestamp":1692676234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/215596\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":162,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1381612829666230410095155","relation":{},"ISSN":["1381-6128"],"issn-type":[{"type":"print","value":"1381-6128"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2022-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}