{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:12:08Z","timestamp":1768536728039,"version":"3.49.0"},"reference-count":300,"publisher":"Bentham Science Publishers Ltd.","issue":"13","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>The average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of\nlife in aged patients and an excessive accumulation of various toxic compounds in the human body during life.\nToday, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body. Phytotherapy with specific approaches is used in alternative medicine to remove toxins\nfrom the body. Worldwide, research is conducted to identify medicinal plant-derived molecules that, with few\nor no side effects, may protect the liver and other organs. This review provides updated information about the\ndetoxification process, the traditional and modern use of the most effective medicinal plants, their active\nmetabolites as detoxifying agents, and the mechanisms and pathways involved in the detoxification process.\nAmong medicinal plants with substantial detoxifying properties, a major part belongs to the Asteraceae family\n(Silybum marianum, Cynara scolymus, Arctium lappa, Helichrysum species, Inula helenium, and Taraxacum officinale). The most widely used hepatoprotective phytocomponent is silymarin, a standardized extract from the Silybum marianum seeds containing a mixture of flavonolignans. Many polysaccharides, polyphenols, and terpenoids have a detoxifying effect. Overall, scientific data on medicinal plants used in phytotherapeutic practice worldwide provides an understanding and awareness of their efficacy in detoxification.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1381612829666230809094242","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T04:33:16Z","timestamp":1691641996000},"page":"988-1015","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Medicinal Plant-derived Phytochemicals in Detoxification"],"prefix":"10.2174","volume":"30","author":[{"given":"Geir","family":"Bj\u00f8rklund","sequence":"first","affiliation":[{"name":"Department of Research, Council for Nutritional and Environmental Medicine (CONEM), Toften 24, Mo i Rana 8610, Norway"}]},{"given":"Nat\u00e1lia","family":"Cruz-Martins","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal"},{"name":"Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal"},{"name":"TOXRUN-Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal"}]},{"given":"Bey Hing","family":"Goh","sequence":"additional","affiliation":[{"name":"Biofunctional Molecule Exploratory (BMEX) Research Group, School of Pharmacy, Monash University Malaysia, Victoria, Malaysia"},{"name":"Institute of Pharmaceutical Science, University of Veterinary and Animal Science, Lahore, Pakistan"},{"name":"Center of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand"}]},{"given":"Olha","family":"Mykhailenko","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, National University of Pharmacy of Ministry of Health of Ukraine, Kharkiv, Ukraine"},{"name":"CONEM Ukraine Bromatology and Medicinal Chemistry Group, National University of Pharmacy, Kharkiv, Ukraine"}]},{"given":"Roman","family":"Lysiuk","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine"},{"name":"CONEM Ukraine Life Science Research Group, Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine"}]},{"given":"Mariia","family":"Shanaida","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine;"}]},{"given":"Larysa","family":"Lenchyk","sequence":"additional","affiliation":[{"name":"CONEM Ukraine Pharmacognosy\nand Natural Product Chemistry Research Group, National University of Pharmacy, Kharkiv, Ukraine"},{"name":"Department of Pharmaceutical Technologies and Quality of Medicines, Institute for Advanced Training of Pharmacy Specialists, National University of Pharmacy, Kharkiv, Ukraine"}]},{"given":"Taras","family":"Upyr","sequence":"additional","affiliation":[{"name":"CONEM Ukraine Pharmacognosy\nand Natural Product Chemistry Research Group, National University of Pharmacy, Kharkiv, Ukraine"}]},{"given":"Marius Emil","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}]},{"given":"Antonina","family":"Pryshlyak","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, I. 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