{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:15:18Z","timestamp":1772446518089,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["COC"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Pentacyclic triterpenes are natural substances, synthesized and present in variable amounts in a large\nnumber of terrestrial and aquatic plants, which act not only as antioxidants and antimicrobials but also as poisons,\nantibiotics, protease inhibitors, and so on. From the organic chemistry point of view, they are compounds derived\nfrom isoprene. These compounds consist of 30 carbons with different substituents, which facilitate their chemical identification and confer\ndifferent physico-chemical and molecular properties. During the last ten years, most of them have been reported to have a variety of\ninteresting and significant biological properties, such as analgesic, anti-allodynic, anti-diabetic, anti-oxidant, anti-parasitic, antimicrobial,\nanti-viral, anti-atherogenic, anti-inflammatory, anti-proliferative, anti-tumour, growth-stimulating activities as well as cardioand\nneuro-protective activity. However, special attention has been focused on the study of their anti-tumour capacity, fundamentally, on\nthe various molecular mechanisms involved in the induction of programmed cell death and the inhibition of metastatic activity, in different\ntypes of cancers. Researchers have also focused on the role that different RNA molecules play in the anti-tumour activity of the major\ntriterpenes studied.\n&lt;\/p&gt;\n&lt;p&gt;\nIn this review, we look at the recent advances reported on the anti-tumorigenic roles of the main representatives of this group of compounds,\nsuch as betulinic (BA), ursolic (UA), oleanolic (OA) and maslinic (MA) acids and some of their derivatives, with a special emphasis\non cell apoptosis and angiogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1385272819666150119225952","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T23:24:52Z","timestamp":1421969092000},"page":"919-947","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Anti-cancer and Anti-angiogenic Properties of Various Natural Pentacyclic Tri-terpenoids and Some of their Chemical Derivatives"],"prefix":"10.2174","volume":"19","author":[{"given":"Eva E.","family":"Rufino-Palomares","sequence":"first","affiliation":[{"name":",0"}]},{"given":"Amalia","family":"Perez-Jimenez","sequence":"additional","affiliation":[{"name":",0"}]},{"given":"Fernando","family":"J. Reyes-Zurita","sequence":"additional","affiliation":[{"name":",0"}]},{"given":"Leticia","family":"Garcia- Salguero","sequence":"additional","affiliation":[{"name":",0"}]},{"given":"Khalida","family":"Mokhtari","sequence":"additional","affiliation":[{"name":",0"}]},{"given":"Antonio","family":"Herrera-Merchan","sequence":"additional","affiliation":[{"name":",0"}]},{"given":"Pedro","family":"P. Medina","sequence":"additional","affiliation":[{"name":",0"}]},{"given":"Juan","family":"Peragon","sequence":"additional","affiliation":[{"name":",0"}]},{"given":"Jose","family":"A. Lupianez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Avenida Fuentenueva s\/n. 18071 Granada, Spain. Biological Sciences Building, 4<sup>th<\/sup> Floor, Offices n\u00c2\u00ba 13 and 14.,Spain"}]}],"member":"965","container-title":["Current Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1385272819666150119225952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/127827\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1385272819666150119225952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:45:26Z","timestamp":1761669926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/127827\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1385272819666150119225952","relation":{},"ISSN":["1385-2728"],"issn-type":[{"value":"1385-2728","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2014-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}